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Preparation and application of montelukast sodium gel plaster

A technology of sodium gel patch and montelukast sodium, which is applied in the field of pharmaceutical preparations and achieves the effects of convenient use, comfortable application and good medication compliance

Pending Publication Date: 2021-07-23
CHANGSHA JINGYI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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  • Preparation and application of montelukast sodium gel plaster
  • Preparation and application of montelukast sodium gel plaster
  • Preparation and application of montelukast sodium gel plaster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Prescription composition:

[0054]

[0055] Preparation Process:

[0056] A. Add purified water to the carbopol and tartaric acid of the prescribed amount to fully swell as phase A;

[0057] B. Mix the prescription amount of sodium polyacrylate, aluminum glycolate, sodium benzoate, talcum powder, dibutyl hydroxytoluene, L-menthol, add the prescription amount of glycerin and sorbitol, stir well, and put it at room temperature as Phase B.

[0058] C. Take another appropriate amount of purified water, add the prescribed amount of montelukast sodium to dissolve it, and use it as phase C. Mix phase A and phase C evenly, then slowly add to phase B, and continue to stir until a uniform drug-containing gel matrix is ​​obtained. The non-woven fabric is used as the backing layer, and the PET polyester film coated with simethicone is used as the anti-adhesive layer, and the above substrates are coated, cut, packaged, etc. to obtain the montelukast sodium gel plaster.

Embodiment 2

[0060] Prescription composition:

[0061]

[0062] Preparation Process:

[0063] A. Add purified water to the carbopol and tartaric acid of the prescribed amount to fully swell as phase A;

[0064] B. Mix the prescribed amount of sodium polyacrylate, aluminum glycylate, talcum powder, and dibutyl hydroxytoluene, add the prescribed amount of glycerin and sorbitol, stir well, and put it at room temperature as phase B.

[0065] C. Take another appropriate amount of purified water, add the prescribed amount of montelukast sodium to dissolve it, and use it as phase C. Mix phase A and phase C evenly, then slowly add to phase B, and continue to stir until a uniform drug-containing gel matrix is ​​obtained. The non-woven fabric is used as the backing layer, and the PET polyester film coated with simethicone is used as the anti-adhesive layer, and the above substrates are coated, cut, packaged, etc. to obtain the montelukast sodium gel plaster.

Embodiment 3

[0067] Prescription composition:

[0068]

[0069] Preparation Process:

[0070] A. Add purified water to the carbopol and tartaric acid of the prescribed amount to fully swell as phase A;

[0071] B. Mix the prescribed amount of sodium polyacrylate, aluminum glycylate, sodium benzoate, talcum powder, and dibutyl hydroxytoluene, add the prescribed amount of glycerin and sorbitol, stir evenly, and put it at room temperature as phase B.

[0072] C. Take another appropriate amount of purified water, add the prescribed amount of montelukast sodium to dissolve it, and use it as phase C. Mix phase A and phase C evenly, then slowly add to phase B, and continue to stir until a uniform drug-containing gel matrix is ​​obtained. The non-woven fabric is used as the backing layer, and the PET polyester film coated with simethicone is used as the anti-adhesive layer, and the above substrates are coated, cut, packaged, etc. to obtain the montelukast sodium gel plaster.

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Abstract

The invention discloses preparation of a montelukast sodium gel plaster and application of the montelukast sodium gel plaster in treatment of infantile asthma. The gel plaster is composed of a back lining layer, a medicine-containing gel layer and a protective film (anti-sticking layer), the medicine-containing gel layer is composed of an active medicine montelukast sodium, a gel matrix material, a humectant, a preservative, a transdermal enhancer and other pharmaceutically acceptable external preparation auxiliary materials. The preparation method of the gel plaster comprises the following steps: uniformly smearing the medicine-containing gel on the backing layer, pasting a protective film, and finally cutting and packaging to obtain the gel plaster. The invention has the advantages that the montelukast sodium gel plaster has the characteristics of high safety, few side effects on gastrointestinal tracts, painless administration and the like when being used for treating the infantile asthma, and the medication compliance of children can be greatly improved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to the preparation and application of a montelukast sodium gel plaster. Background technique [0002] Montelukast sodium is a cysteinyl leukotriene receptor antagonist, which is a drug with anti-asthma and anti-allergic effects (see Hon et al, Drug Design, Development and Therapy, 8, 839 (2014)) . Cysteinyl leukotrienes are potent inflammatory mediators released by mast cells, eosinophils and other cells. Montelukast sodium can block the combination of cysteinyl leukotrienes and receptors on the respiratory tract and nasal mucosa, and inhibit bronchoconstriction, mucus secretion, and increased vascular permeability caused by cysteinyl leukotrienes. tract inflammatory response. Montelukast sodium can also relieve the nasal congestion symptoms of allergic dermatitis. Clinically, montelukast sodium is mainly used for the prevention and long-term treatment of adult asthma, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/47A61K47/32A61P11/06
CPCA61K9/7023A61K31/47A61K47/32A61P11/06
Inventor 张海龙曾飞
Owner CHANGSHA JINGYI PHARM TECH CO LTD
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