Application of mulberry extract in preparation of drugs for reducing body weight of animal

An extract, animal technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of administration method, unclear dose-effect relationship, etc., and achieve the effect of no adverse reactions, clear ingredients, and low cost

Inactive Publication Date: 2021-07-23
BEIJING WEHAND BIO PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there are some reports on weight loss and lipid-lowering of mulberry extracts. For example, patent application CN1631246A discloses the weight-loss and lipid-lowering effects of mulberry extracts. Specifically, mulberry ethanol extracts can reduce the weight of NIH mice and reduce blood Triglyceride and cholesterol levels, but its administration method and dose-effect relationship are not clear; patent application CN102370708A discloses the application of Chinese herbal medicine mulberry leaf water extract or alcohol extract in the preparation of weight-loss and lipid-lowering drugs, and records that mulberry extract The application of weight loss and lipid lowering
There is no research report on the effect of mulberry-related extracts on the body weight of KKAy mice

Method used

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  • Application of mulberry extract in preparation of drugs for reducing body weight of animal
  • Application of mulberry extract in preparation of drugs for reducing body weight of animal
  • Application of mulberry extract in preparation of drugs for reducing body weight of animal

Examples

Experimental program
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Effect test

Embodiment 1

[0030] The preparation of embodiment 1 mulberry extract 1

[0031] Take 1000 kg of fresh mulberry branches (Xiaza Sangyuesang No. 11), crush them, add 4000 L of water, extract by heating and reflux for 2 hours, combine the extracts, filter to remove insoluble matter, and obtain a crude extract. The crude extract was thermally concentrated until the solid content reached 4%, and kept at 50°C as the sample solution for the cationic resin column.

[0032] Use 150kg of D113 type macroporous weakly acidic styrene-acrylic cationic resin to pack the column, use 2mol / L hydrochloric acid solution to wash until the pH of the eluate is 4.5; use 1mol / L sodium hydroxide solution to wash until the pH of the eluate is 8.5; 2mol / L hydrochloric acid solution until the pH of the eluate is 4.5; then rinse with 5 times the column volume of deionized water to complete the activation. Load the concentrated extract, then use 1000L 2.5mol / L ammonia water to elute, the elution rate is 6BV / h, and col...

Embodiment 2

[0036] The preparation of embodiment 2 mulberry extract 2

[0037]Take 10kg of fresh mulberry branches (Sangteyou No. 2), crush them, add 150L of water, add in 2 times, extract by decoction for 3 hours each time, combine the extracts, and filter to remove insoluble matter. The extract was thermally concentrated until the solid content reached 8%, and then transferred to an alcohol sink, and 2367.9 g of absolute ethanol (3 L) was added at 300 rpm with a stirring blade. After the ethanol was added, the stirring was stopped, and the alcohol was precipitated for 24 hours, and the supernatant was taken as the sample solution for the cationic resin column. Use 002SC type strongly acidic styrenic cationic resin 5kg packing column, according to the method for embodiment 1, cationic resin is activated. Load the extract that has been concentrated and alcohol-precipitated, and then use 100L5mol / L potassium chloride to elute at a rate of 5BV / h. Use 20% silicotungstic acid to detect the e...

Embodiment 3

[0043] The preparation of embodiment 3 mulberry extract 3

[0044] Take 1000 kg of fresh mulberry branches (Guangdong mulberry), crush them, add 11500 L of water, heat and reflux for extraction for 2 hours, combine the extracts, filter to remove insoluble matter, and obtain a crude extract. The crude extract is first centrifuged to remove impurities, and then concentrated with a reverse ion osmosis membrane until the solid content reaches 1%, which is used as the sample solution for the cationic resin column.

[0045] Use 300 kg of D001 type macroporous strongly acidic styrene-based cationic resin to pack into a column, and activate the cationic resin according to the method of Preparation Example 1. Load the concentrated crude extract, use 5000L 0.04mol / L ammonium nitrate to elute, the elution rate is 5BV / h, use 20% silicotungstic acid to detect the effluent, start to collect when white precipitate is formed, when collected When the liquid reaches 1000L, stop collecting.

...

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Abstract

The invention relates to application of a mulberry extract in preparation of drugs for reducing body weight of an animal. The mulberry extract is characterized by containing alkaloids, polysaccharides, amino acids and flavones; and preferably, the mulberry extract contains the ingredients in weight content: 3%-99% of alkaloids, 0.2%-70% of polysaccharides, 0%-10% of flavones, 0%-50% of amino acids and 0%-25% of other ingredients. The mulberry extract disclosed by the invention can be used for controlling type 2 diabetes accompanying ponderal growth and has a good treatment effect on type 2 diabetes merged obesity.

Description

technical field [0001] The present invention relates to the application of mulberry extract in the preparation of medicine for reducing animal weight. Background technique [0002] Obesity and overweight are increasing at an alarming rate worldwide as living standards improve. Epidemiological studies have shown that obesity and overweight are important risk factors for diabetes, cardiovascular disease, cancer and premature death. The causes of obesity include an increase in the volume of adipocytes and an increase in the number of adipocytes. The increase in the number of adipocytes is caused by the differentiation of preadipocytes into mature adipocytes, and the differentiation of preadipocytes into mature adipocytes occurs in a series of Activation and expression of transcription factors. Data show that the number of diabetic patients ranks first in the world, among which the proportion of overweight people is 41.0%, and the proportion of obese people is 24.3%. Compared...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61P3/04A61P3/10
CPCA61K36/605A61K2236/15A61K2236/30A61K2236/39A61K2236/55A61P3/04A61P3/10
Inventor 刘玉玲申竹芳刘率男曹慧刘志华刘泉李彩娜雷蕾陈艳敏朱向阳邹媛媛
Owner BEIJING WEHAND BIO PHARMA CO LTD
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