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A kind of preparation method of andrographolide enteric-coated dry suspension

A technology of andrographolide and dry suspension, applied in the field of medicine, can solve problems such as easy degradation of andrographolide, and achieve the effects of improving bioavailability, protecting quality and increasing compliance

Active Publication Date: 2022-02-08
HUANGSHAN C KING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides a preparation method of andrographolide enteric-coated dry suspension, which solves the problem that existing andrographolide is easily degraded in gastric juice

Method used

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  • A kind of preparation method of andrographolide enteric-coated dry suspension
  • A kind of preparation method of andrographolide enteric-coated dry suspension
  • A kind of preparation method of andrographolide enteric-coated dry suspension

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preparation example Construction

[0041] The invention discloses a preparation method of andrographolide enteric-coated dry suspension, comprising the following steps:

[0042] (1) Preparation of particulate matter

[0043] Dissolve hydroxypropyl cellulose with 20% to 95% ethanol aqueous solution and add sodium lauryl sulfate to prepare a solvent with a solid content of 3% to 5% as a binder;

[0044] After sieving andrographolide, lactose and microcrystalline cellulose, add them to a high-speed centrifugal granulation coating machine, and carry out spray granulation with the binder. The mesh number of andrographolide, lactose and microcrystalline cellulose sieved In practice, conventional settings are required; dry the granules after they are formed; the spray rate of the high-speed centrifugal granulator coating machine is 2-15mL / min, the speed is 100-300r / min, and the rotation is 10-30min; the drying temperature is 40°C, and the drying time is 8-12 hours, the dried particles pass through a 60-100 mesh sieve...

Embodiment

[0067] The above method was used to prepare andrographolide enteric-coated dry suspension, and the specific composition ratios are shown in Table 1 and Table 2 below.

[0068] Table 1 Raw material ratio (parts by weight)

[0069]

[0070] Table 2 Raw material ratio (parts by weight)

[0071]

[0072]

[0073] Andrographolide enteric-coated dry suspension was prepared according to the ratios in Table 1 and Table 2, and the process parameters for preparing granules by a high-speed centrifugal granulator coating machine are shown in Table 3 below.

[0074] Table 3 Process parameters for the preparation of particulate matter

[0075] group Speed / r·min -1

Rotation time / min Spray rate / mL2min -1

Drying time / h 1 160 20 8 10

[0076] After the preparation of the granules is completed, the granules are coated with an isolation layer and an enteric layer, and the process parameters of the coating machine during the process of coating the i...

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Abstract

The invention relates to the technical field of medicine, in particular to a preparation method of andrographolide enteric-coated dry suspension. The specific technical scheme is: a preparation method of andrographolide enteric-coated dry suspension, specifically: adding sodium lauryl sulfate after dissolving hydroxypropyl cellulose to prepare a solvent with a solid content of 3% to 5% as a solvent Adhesive, and then sieve andrographolide, lactose and microcrystalline cellulose and add to the high-speed centrifugal granulation coating machine, and then dry after the granules are formed; in the coating machine, isolate the dried granules layer and enteric-coated layer, and finally mixed with suspending agent and flavoring agent to finally prepare andrographolide enteric-coated dry suspension. The invention solves the problem that the existing andrographolide dispersible tablets are easily degraded in gastric juice.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of andrographolide enteric-coated dry suspension. Background technique [0002] Andrographolide, molecular formula C 20 h 30 o 5 , the main active ingredient of the natural plant Andrographis paniculata, has the effects of dispelling heat and detoxification, reducing inflammation and relieving pain, and has special curative effects on bacterial and viral upper respiratory tract infections and dysentery. It is known as a natural antibiotic drug. [0003] Andrographolide preparations for clinical application mainly include andrographolide tablets, andrographolide soft capsules, andrographolide dripping pills, and andrographolide dispersible tablets, all of which are gastric-soluble preparations. The test results of Andrographolide Tablets, Andrographolide Soft Capsules, Andrographolide Dropping Pills, and Andrographolide Dispersible Tablets under weak acid ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/38A61K47/32A61K31/365A61P31/04A61P31/12A61P11/00A61P1/12A61J3/00
CPCA61K9/5073A61K9/5089A61K9/5047A61K9/5026A61K31/365A61P31/04A61P31/12A61P11/00A61P1/12A61J3/005A61J2200/42
Inventor 司鹏付杰周世文
Owner HUANGSHAN C KING PHARMA
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