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Stable vaccine against clostridium difficile

A technology selected from CH2, used in antibacterial drugs, immunoassays, antibody medical components, etc., can solve problems such as increasing production costs and complexity of vaccine delivery

Pending Publication Date: 2021-07-23
IDORSIA PHARM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, lyophilization and refrigeration of vaccines results in increased production costs and complexity in vaccine delivery, as an efficient cold chain system is required to ensure optimal temperatures during transport, storage and handling

Method used

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  • Stable vaccine against clostridium difficile
  • Stable vaccine against clostridium difficile
  • Stable vaccine against clostridium difficile

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0782] A. chemical synthesis

[0783] General information:

[0784] Commercial grade solvents were used unless otherwise stated. Drying solvents were obtained from Waters Dry SolventSystem. Solvents used in chromatography are distilled before use. Sensitive reactions were performed in heat-dried glassware under an argon atmosphere. Analytical thin layer chromatography (TLC) was performed on Kieselgel 60F254 glass plates pre-coated with silica gel at a thickness of 0.25 mm. By staining with vanillin solution (6% (w / v) vanillin and 10% (v / v) sulfuric acid in 95% ethanol) or Hanessian's stain (5% (w / v) in water ) ammonium molybdate, 1% (w / v) cerium(II) sulfate and 10% (v / v) sulfuric acid) staining. Silica gel column chromatography was performed on Fluka Kieselgel 60 (230-400 mesh).

[0785] 1 H, 13 C and two-dimensional NMR spectra were measured at 296 K using a Varian 400-MR spectrometer. Chemical shifts (d) relative to the corresponding residual solvent peaks (CDCl...

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Abstract

The present invention relates to a synthetic saccharide of general formula (I) that is related to Clostridium difficile PS-II cell-surface polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and / or treatment of diseases associated with Clostridium difficile. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Clostridium difficile bacteria.

Description

technical field [0001] The present invention relates to synthetic saccharides of general formula (I) and conjugates thereof related to Clostridium difficile (Clostridium difficile) PS-II cell surface polysaccharides. Said synthetic saccharides, said conjugates and pharmaceutical compositions comprising said synthetic saccharides or said conjugates are hydrolysis-resistant, long-term stable, thermostable, and are useful for the prophylaxis and / or treatment of bacillus (now known as Clostridioides difficile) associated diseases. Furthermore, synthetic saccharides of general formula (I) are useful in immunoassays as markers for the detection of antibodies against Clostridium difficile. Background technique [0002] Clostridium difficile, formerly known as Clostridium difficile, is a Gram-positive spore-forming anaerobic bacterium considered to be the most important identifiable cause of nosocomial diarrhea. The terms Clostridium difficile and Clostridium difficile are synonym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04A61K31/702A61K31/08A61K31/40A61P31/04
CPCC07H17/04A61P31/04C08B37/006A61K47/6415A61K47/646G01N2469/20G01N33/56911A61K39/08A61K2039/55505A61K2039/6037C07H1/00
Inventor 马杜·埃玛迪马里尔达·P·里斯本丹尼尔·克诺普博帕纳·蒙南达阿恩·冯博宁克拉尼·列别夫·佩雷拉
Owner IDORSIA PHARM LTD