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Application of radix crotonis crassifolii extract in preparation of medicine for preventing and/or treating ulcerative colitis

A technology of ulcerative colitis and chicken bone incense, which is applied in the field of biomedicine to achieve the effects of reducing cell infiltration, relieving colon shortening and improving colon inflammation

Active Publication Date: 2021-08-06
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Experimental studies have shown that both the alcohol extract and the water extract of the chicken bone have anti-inflammatory effects. In addition, patents CN110294766A and CN110540530A have disclosed that the root extract of the chicken bone has anti-tumor activity, but the current research on the effect of the chicken bone on ulcerative colitis The effect has not been reported yet and needs to be developed and researched

Method used

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  • Application of radix crotonis crassifolii extract in preparation of medicine for preventing and/or treating ulcerative colitis
  • Application of radix crotonis crassifolii extract in preparation of medicine for preventing and/or treating ulcerative colitis
  • Application of radix crotonis crassifolii extract in preparation of medicine for preventing and/or treating ulcerative colitis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of embodiment 1 Jiguxiang extract

[0048] Take 1250g of Jiguxiang medicinal material, add 10 times the weight of 95% (volume) ethanol respectively, heat and reflux at 60°C for 2h, 1h, and 45min for 3 extractions, filter, combine the reflux liquid and concentrate it into a thick paste, freeze-dry under reduced pressure Obtain the chicken bone extract afterward.

Embodiment 2

[0050] 1. Experimental method

[0051] 1. Establishment and administration of experimental animal models of ulcerative colitis

[0052] All C57BL / 6 mice were of SPF grade and were adaptively fed for one week. They were reared at a temperature of 25±1°C, a humidity of 55±5%, and a 12-hour day-night cycle. Experimental animals were randomly divided into 5 groups, 6 animals in each group, free to eat and drink.

[0053] (1) Control group (Control group): All mice drank sterile distilled water freely, and fed a corresponding volume of CMC-Na solution for 10 days;

[0054] (2) Model group (DSS group): Mice were given 3% DSS aqueous solution to drink freely for 7 days, and fed with a corresponding volume of CMC-Na solution for 10 consecutive days, once a day;

[0055] (3) Mesalazine group (Mesalazine group): the mice were given 3% DSS aqueous solution to drink freely for 7 days, and the corresponding volume of mesalazine (100 mg / kg, ground into mesalazine enteric-coated tablets) ...

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Abstract

The invention discloses an application of a radix crotonis crassifolii extract in preparation of a medicine for preventing and / or treating ulcerative colitis. The research finds that the radix crotonis crassifolii extract can obviously relieve symptoms such as colon shortening, colon injury, diarrhea and hematochezia, alleviate tissue inflammatory cell infiltration, and reduce expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at a colon part; and it proves that the radix crotonis crassifolii extract can relieve the ulcerative colitis by protecting the inherent structure of colon tissue and improving the colitis disease, so that a novel natural medicine choice is provided for preventing and / or treating the ulcerative colitis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of the extract of Jiguxiang in the preparation of medicines for preventing and / or treating ulcerative colitis. Background technique [0002] The incidence of ulcerative colitis (UC) is increasing year by year in the world, and the incidence in our country also has an increasing trend. The pathogenesis of UC is still unclear, mainly involving genetic susceptibility, epithelial barrier defect, immune response dysregulation, and environmental factors. The disease is a chronic inflammation of the intestinal mucosa. The lesion is mostly in the rectum and can even spread to the proximal colon. The main clinical manifestations are bloody diarrhea, abdominal pain, blood in the stool, and weight loss. UC has a long course of disease and is prone to recurrent attacks, and may even develop into colon cancer. It is recognized by the WHO as a modern refra...

Claims

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Application Information

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IPC IPC(8): A61K36/47A61P1/04
CPCA61K36/47A61P1/04A61K2236/333A61K2236/51
Inventor 赵钟祥崔辉江诗琴杨伟群沈秀婷
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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