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Composite nano material, preparation method and application thereof

A composite nanomaterial and solution technology, applied in the field of mass spectrometry detection, achieves the effects of good linear relationship, good repeatability and simple operation

Active Publication Date: 2021-08-06
SHANDONG AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies have reported that AuNPs target plate can be used for the detection of metronidazole in liver acetone extract in vitro, and metronidazole can be detected, but there will be many endogenous substance peaks that interfere with mass spectrometry when AuNPs are used alone.

Method used

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  • Composite nano material, preparation method and application thereof
  • Composite nano material, preparation method and application thereof
  • Composite nano material, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Preparation of composite nanomaterials AuNPs / NiFe-LDHs

[0048] 1) The nano-gold material was synthesized according to the Frens method, and a slight modification was made to adjust the order of adding trisodium citrate (Mw258) and chloroauric acid solutions: first, 50 mL of 4 mM trisodium citrate (Mw 258) aqueous solution was heated to reflux Stir until boiling (about 140°C), add 0.25mL of 200mM chloroauric acid into the boiling solution, heat and reflux for 3min, and obtain (color: light yellow→black purple→wine red) particle size 11-16nm, pH5. 5 gold nanometer solution (AuNPs solution), the obtained AuNPs solution (Au concentration of 1 ± 0.001mM) was diluted 4 times with deionized water.

[0049] 2) Disperse 25mg of NiFe-LDHs in 100mL ethanol solution.

[0050] 3) An equal volume of AuNPs solution was mixed with NiFe-LDH supernatant (1:1, v / v), and sonicated at 200W for 30min at room temperature. After AuNPs and NiFe-LDHs self-assembled completely, they were u...

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Abstract

The invention discloses a composite nano-material, a preparation method and application thereof, and belongs to the technical field of mass spectrometric detection.The composite nano-material comprises a gold colloidal solution and ferronickel-layered double hydroxides, the volume ratio of the gold colloidal solution to the ferronickel-layered double hydroxides is (1-3):(1-3), and according to the preparation method, an improved Frens method is used for synthesizing a nano-gold material; and NiFe-LDHs and AuNPs are self-assembled to form the composite nano material, the composite nano material is used for detecting metronidazole and metabolite thereof, the detection result repeatability is good, the linear relation is good, and the composite nano material can be used for quantification.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry detection, in particular to a composite nanomaterial, a preparation method and an application thereof. Background technique [0002] Metronidazole (MNZ) is a commonly used anti-protozoal infection and anti-anaerobe antibiotics. It has growth-promoting effect and is widely used in clinic and livestock and poultry breeding. However, metronidazole and some metabolites are potentially harmful to humans and animals (may cause typical adverse reactions such as nausea, urticaria, and polyneuropathy). However, illegal or irrational use will cause metronidazole and its antibiotics to enter water, soil, and animal-sourced foods (meat, eggs, milk, honey, etc.) through various routes, and gradually accumulate in the surrounding ecosystem. In addition, metronidazole and its metabolites are difficult to remove due to their nondegradability and high solubility. At present, the detection methods of me...

Claims

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Application Information

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IPC IPC(8): G01N27/626
CPCG01N27/628
Inventor 马春霞郑振佳李玲玉王明林徐龙华
Owner SHANDONG AGRICULTURAL UNIVERSITY
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