Core-shell upconversion MOFs photosensitive composite material, preparation method and application thereof

A composite material and nanocomposite material technology, applied in the preparation, application of synergistic chemotherapy and near-infrared photodynamic therapy, the field of core-shell up-conversion MOFs photosensitive composite material, can solve the problems such as MOFs photosensitizers that have not been found yet, and achieve excellent resistance. effect of tumor

Inactive Publication Date: 2021-08-10
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to various technical difficulties, no near-infrared-activated MOFs photosensitizer developed by utilizing the synergistic effect of UCNPs and MOFs, and a composite material that uses its efficient energy transfer process to achieve PDT efficacy has not yet been found.

Method used

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  • Core-shell upconversion MOFs photosensitive composite material, preparation method and application thereof
  • Core-shell upconversion MOFs photosensitive composite material, preparation method and application thereof
  • Core-shell upconversion MOFs photosensitive composite material, preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0043] The core-shell up-conversion MOFs photosensitive composite material that the present embodiment provides, it is above-conversion nanoparticle NaYF 4 :Yb,Er@NaYF 4 As the core, the photosensitive Al-MOF is used as the shell, and the shell is loaded with the anticancer drug DOX at the same time MOFs structure nanocomposite, that is, UCNP@MOF-DOX; the nanocomposite emits red light when excited by 980 nm near-infrared light light and green light; the upconversion nanoparticles NaYF 4 :Yb,Er@NaYF 4 In, the dosage of Yb is NaYF 4 15%~25% of molar weight, be 15% in the present embodiment; The consumption of Er is NaYF 4 1% to 3% of the molar weight, the present embodiment is 1%. The MOFs structure is Al-MOF, wherein Al-MOF and NaYF 4 :Yb,Er@NaYF 4 The concentration ratio is 1:2. The anticancer drug DOX is doxorubicin hydrochloride, and its mass proportion is 7.0% to 8.0% of the total mass of the UCNP@MOF-DOX nanocomposite material, which is 7% in this embodiment.

[00...

Embodiment 2

[0056] The core-shell up-conversion MOFs photosensitive composite material, preparation method and application provided in this example are basically the same as those in Example 1, except that:

[0057] In the core-shell up-conversion MOFs photosensitive composite material provided by this embodiment, the up-conversion nanoparticles NaYF 4 :Yb,Er@NaYF 4 In, the dosage of Yb is NaYF 4 20% of the molar weight, the amount of Er is NaYF 4 2% of the molar amount; the anticancer drug DOX is doxorubicin hydrochloride, and its mass ratio is 7.5% of the total mass of the UCNP@MOF-DOX nanocomposite.

[0058] Described step (1) comprises following concrete steps:

[0059] (11) Take 0.78 mmol Y(CH 3 COO) 3 , 0.2 mmol of Yb (CH 3 COO) 3 and 0.02 mmol of Er(CH 3 COO) 3 ) metal-acetate precursor, placed in a 100 mL flask containing a mixed solution of 6 mL OA and 15 mL ODE; heated to 150 °C to form a homogeneous solution, then cooled to below 60 °C; heated to 150 °C C forms the re...

Embodiment 3

[0066] The core-shell up-conversion MOFs photosensitive composite material, preparation method and application provided in this example are basically the same as those in Examples 1 and 2, except that:

[0067] In the core-shell up-conversion MOFs photosensitive composite material provided by this embodiment, the up-conversion nanoparticles NaYF 4 :Yb,Er@NaYF 4 In, the dosage of Yb is NaYF 4 25% of the molar weight, the amount of Er is NaYF 4 3% of the molar amount; the anticancer drug DOX is doxorubicin hydrochloride, and its mass ratio is 8% of the total mass of the UCNP@MOF-DOX nanocomposite.

[0068] The core-shell UCNP@MOF upconversion nanomaterial is the upconversion nanoparticle as the core, and the photosensitive Al-MOF as the shell while loading the anticancer drug DOX in a set ratio.

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Abstract

The invention relates to the field of biomedical luminescent materials, and discloses a core-shell upconversion MOFs photosensitive composite material, which is an MOFs structure nanocomposite material with upconversion nanoparticles NaYF4:Yb,Er@NaYF4 as a core and photosensitive Al-MOF as a shell layer, and the shell layer is loaded with an anti-cancer drug DOX at the same time, namely UCNP@MOF-DOX. The nano composite material emits red light and green light under the excitation of 980 nm near-infrared light. The invention also discloses a preparation method and application of the core-shell upconversion MOFs photosensitive composite material. Under the excitation of 980 nm laser, the green up-conversion emission of the UCNPs can trigger the photosensitive Al-MOFs to generate a large amount of singlet oxygen (1O2) for photodynamic therapy, and shows an excellent anti-tumor effect in cooperation with near-infrared light induced PDT and chemotherapy. The material can be used for preparing light-sensitive materials for fluorescence imaging, synergistic chemotherapy and near-infrared photodynamic therapy. The MOFs material is degradable, overcomes the danger of long-term retention in the body, and has high application value in the field of biomedicine.

Description

technical field [0001] The invention belongs to the field of biomedical luminescent composite materials, and in particular relates to a core-shell up-conversion MOFs photosensitive composite material, a preparation method, and its application in synergistic chemotherapy and near-infrared photodynamic therapy. Background technique [0002] Metal-organic frameworks, as a new type of crystalline porous coordination polymers, consist of inorganic vertices (metal ions or clusters) and organic linkers. Their unique properties such as high specific surface area and tunable structure make them suitable for a wide range of applications, especially in gas storage and separation, heterogeneous catalysis, sensing, nonlinear optics, biomedicine, etc. Due to the diversity of metal ions and ligands in MOFs, multiple functions can be tailored by selecting functionalized secondary building blocks and organic ligands. Therefore, MOFs have received increasing attention due to their ability to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/34A61K31/704A61K47/58A61K49/00A61P35/00B82Y5/00B82Y20/00B82Y30/00B82Y40/00
CPCA61K41/0057A61K31/704A61K9/5146A61K47/58A61K49/0093A61K49/0054B82Y5/00B82Y20/00B82Y30/00B82Y40/00A61P35/00
Inventor 刘金亮陆佳琳张勇陈晨张超凡
Owner SHANGHAI UNIV
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