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Application of formononetin in preparation of medicines for treating or/and preventing depression

A technology of formononetin and depression, which is applied in the field of biomedicine, can solve the problems of significant side effects, central nervous system inflammation and depression, low side effects, and lack of effective treatment, so as to achieve small side effects and adverse reactions Small, low-cost effect

Active Publication Date: 2021-08-13
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects of these drugs are more significant
[0005] It can be seen that the existing western medicine treatment scheme lacks drugs that can effectively treat central nervous system inflammation and depression and have low toxic and side effects

Method used

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  • Application of formononetin in preparation of medicines for treating or/and preventing depression
  • Application of formononetin in preparation of medicines for treating or/and preventing depression
  • Application of formononetin in preparation of medicines for treating or/and preventing depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The embodiment of the present application provides different modeling treatments for rats, including:

[0049] Thirty healthy male SD rats were selected, aged about 6 weeks, and weighing between (200±20) g. In a clean animal room, room temperature (21±2)°C, relative humidity 30%-40%, light and dark for 12 hours, light time from 7:00 am to 19:00 pm, and dark time from 19:00 pm to 7:00 am the next day Time. Rats were fed adaptively for one week, and were randomly divided into experimental groups after weighing.

[0050] The animal model of depression-like behavior was prepared by intraperitoneal injection of LPS. The LPS was dissolved in sterile water and the injection volume was 1 mg / mL. It was fed at 9 am on the first day of model establishment for two consecutive days. The dose of formononetin in the lipopolysaccharide LPS+formononetin administration group was 30 mg / kg·d, and the intragastric volume was 1 mL / 100g body weight.

[0051]The experimental rats were rando...

Embodiment 2

[0053] This embodiment provides the general state and body weight changes of the Control group, LPS group and LPS+F group of embodiment 1, specifically including:

[0054] The mental state, fur color, and autonomous activity of the rats were observed daily. From the day before modeling, the rats were weighed and recorded every day to observe and compare the changes in the weights of the rats in each group.

[0055] One day before modeling, the rats in each group were in good mental state, with black and soft fur, flexible movements, spherical feces and moderate dryness and wetness. On the 5th day after modeling, the rats in the LPS group had a poor mental state, messy hair, yellow color, and decreased activity. The mental state of the rats in the LPS+F group was acceptable, the hair was more tidy, and the movements were sensitive and lively. Body weight analysis of rats as figure 1 Shown: On the 5th day of modeling, compared with the Control group, the body weight of the ra...

Embodiment 3

[0057] The present embodiment provides the sugar water preference test of the Control group, the LPS group and the LPS+F group of embodiment 1, specifically including:

[0058] Observe the depression-like behavior of the Control group, LPS group and LPS+F group experimental animals of Example 1. Start the experimental process in a quiet environment. The experiment started training two days in advance. On the first day, rats were given a bottle of sugar water (1% sucrose) and a bottle of pure water, and on the second day, rats were given two bottles of pure water. After fasting for 24 hours on the third day, the rats were placed in a cage with a bottle of sugar water (1% sucrose) and a bottle of pure water, and the amount of sugar water and pure water that the rats drank within 4 hours was calculated and calculated. Statistics of their sugar water preference rate. Sugar water preference rate = the amount of drinking sugar water / (the amount of drinking sugar water + the amou...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to application of formononetin in preparation of medicines for treating or / and preventing depression. On the first aspect, the invention discloses application of the formononetin in preparation of medicines for treating or / and preventing depression; and on the second aspect, the invention discloses application of the formononetin in preparation of medicines for treating or / and preventing central nervous system inflammation. The formononetin disclosed by the invention is a medicine which is high in safety and small in adverse reaction and is used for resisting depression and inhibiting neuroinflammation.

Description

technical field [0001] The application belongs to the technical field of biomedicine, and in particular relates to the application of formononetin in the preparation of drugs for treating or / and preventing depression. Background technique [0002] Depression is a common psychiatric disease, and it is one of the three major diseases together with cancer and AIDS. Clinically, it is characterized by persistent fatigue, sluggish response, depressed mood, loss of appetite, decreased speech, and weight loss. In severe cases, it ranges from depression to grief, and even delusions, hallucinations, or unrealistic behaviors. The main symptoms of behavior, and at the same time have the typical characteristics of high morbidity, mortality and disability. With the gradual development of the economy and society, people's pace of life increases, and people are under increasing pressure, resulting in an increasing incidence of depression year by year. [0003] At present, the etiology and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P25/24A61P25/00A61P29/00
CPCA61K31/352A61P25/24A61P25/00A61P29/00
Inventor 陈家旭黄俊卿姚志红郝闻致何亮亮鄢黎朱潇旭王雅平
Owner JINAN UNIVERSITY
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