Single-end-capped organosiloxane oligomer, silicone hydrogel, corneal contact lens and preparation methods of single-end-capped organosiloxane oligomer, and corneal contact lens

Abstract

The invention discloses a single-end-capped organosiloxane oligomer. The single-end-capped organosiloxane oligome can be well mixed with various hydrophilic monomers under the condition of no hydrotropy of a solvent, overcomes the problem of difficult mutual dissolution of the organosiloxane oligomer and hydrophilic monomers, and can be used for preparing a silicon hydrogel material with high oxygen permeability and high hydrophilicity. Meanwhile, the invention further provides the silicon hydrogel which is formed by polymerizing the single-end-capped organosiloxane oligomer, hydrophilic monomers and the like. No solvent is added in the formula of the silicon hydrogel, so large-scale industrial production of the silicon hydrogel is facilitated. The addition proportion of the organosiloxane oligomer in the silicon hydrogel is large, so the silicon hydrogel has high oxygen permeability, and meanwhile, the high hydrophilicity and flexibility of the gel are also maintained. The invention also provides a corneal contact lens. The corneal contact lens is prepared from the silicone hydrogel material and has the advantages of high oxygen permeability, strong hydrophilicity, good light transmission, less lipid precipitation, good flexibility, comfort in wearing and the like.

Description

technical field [0001] The invention relates to a single-terminated organosiloxane oligomer, silicon hydrogel, corneal contact lens and a preparation method, and belongs to the field of material preparation of contact lens lenses. Background technique [0002] Contact lenses, also known as contact lenses, are lenses that are worn directly on the human eyeball to correct vision. Compared with ordinary glasses, contact lenses are convenient, beautiful and comfortable. Contact lenses can be divided into rigid contact lenses and soft contact lenses. Rigid contact lenses, due to their hard material and poor wettability, may easily cause discomfort to the eyeballs when worn. Soft contact lenses have good chemical stability, light transmission, biocompatibility, ion permeability and mechanical properties, and are more comfortable to wear. [0003] In the development history of the soft contact lens industry, the hydrogel material made of acrylic acid first appeared. In the 1970s...

AI Technical Summary

Problems solved by technology

However, due to the high hydrophobicity of PDMS, the compatibility with hydrophilic monomers is poor, and the addition amount is limited, which limits the improvement of the oxygen permeability value of the material; and the obtained silicone hydrogel has a strong surface hydrophobicity, which affects the performance of the lens. Wearing comfort

[0007] In addition, due to the low surface energy and hydrophobicity of PDMS, after the polymerization of silicone monomers and hydrophilic monomers, the silicon-containing groups easily migrate to the surface of the silicon hydrogel, resulting in higher lipid adsorption.

Excessive lipid adsorption on the lens can easily cause blurred vision, reduce wearing comfort, and cause inflammation when worn for a long time

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