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A kind of preparation method of antibacterial quaternized chitosan/ag hybrid nano hydrogel

A technology of quaternized chitosan and nano-hydrogels, which is applied in the field of preparation of antibacterial quaternized chitosan/Ag hybrid nano-hydrogels, can solve the problem of limiting the wide application of Ag nanoparticles, Ag nanoparticles Easy to agglomerate, not enough to meet antibacterial needs, etc., to achieve excellent structural stability and antibacterial performance, good water dispersibility, and improve the effect of bonding fastness

Active Publication Date: 2022-06-28
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial ability of unmodified chitosan is often weak, which is not enough to meet the complex and changeable antibacterial requirements. The water solubility and antibacterial performance of chitosan modified by quaternization can be significantly improved [Carbohydrate Polymers, 2020, 247, 116754-116765.】
Ag nanoparticles are favored because of their broad-spectrum, high-efficiency, and low-drug-resistance antibacterial properties, but Ag nanoparticles are prone to agglomeration and difficult to process, which limits the wide application of Ag nanoparticles to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 2.5g Ag nanoparticles (average size 18nm) were added to a mixed solvent of 250g water and 250g ethylene glycol, and ultrasonically treated for 20min at a power of 300W to obtain a dispersion of Ag nanoparticles, and then the temperature was adjusted to 30°C , adding an ethylene glycol solution containing 3.85 mg of 2-aminoethanethiol, and reacting for 2 h to obtain Ag nanoparticles modified with surface amino groups. The product is purified and dried for later use. The amino-modified Ag nanoparticles were redispersed in deionized water, and the amino-modified Ag nanoparticles aqueous dispersion was obtained after ultrasonic treatment at a power of 300 W for 20 min.

[0038] 0.0125 g of emulsifier P(E / B)-PEO was weighed and dissolved in 12.5 g of isoparaffin (isopar M, Exxon Mobil) to obtain an emulsifier solution. 0.3g quaternized chitosan and 5mg NaBF 4 Dissolved in 2 g of purified Ag nanoparticle aqueous dispersion (wherein the amino-modified Ag nanoparticle content ...

Embodiment 2

[0043] Add 0.5 g of Ag nanoparticles (average size of 15 nm) to 250 g of water and 250 g of ethylene glycol, and ultrasonically treat it for 10 min at a power of 450 W to obtain a dispersion of Ag nanoparticles. The ethylene glycol solution of 1 mg of 2-aminomercaptopropionic acid was reacted for 12 hours to obtain Ag nanoparticles with surface amino group modification. The product was purified and dried for later use. The amino-modified Ag nanoparticles were redispersed in deionized water, and the amino-modified Ag nanoparticles aqueous dispersion was obtained after ultrasonic treatment at a power of 450W for 10 min.

[0044] 1.5 g of emulsifier Tween 80 and 1.5 g of Span-80 were weighed and dissolved in 30 g of toluene to obtain an emulsifier solution. 0.42g quaternized chitosan and 8.3mg NaBF 4 Dissolved in 2.5 g of purified Ag nanoparticle aqueous dispersion (wherein the amino-modified Ag nanoparticle content was 15 mg), the obtained dispersion was added to the above emul...

Embodiment 3

[0049] Add 0.75 g of Ag nanoparticles (average size of 20 nm) to 250 g of water and 250 g of dimethyl sulfoxide, and ultrasonically treat it for 10 min at a power of 500 W to obtain a dispersion of Ag nanoparticles, and then adjust the temperature to 30 ° C, A dimethyl sulfoxide solution containing 1.5 mg of 2-aminoethanethiol was added, and the reaction was carried out for 10 h to prepare Ag nanoparticles modified with surface amino groups. The product was purified and dried for later use. The amino-modified Ag nanoparticles were redispersed in deionized water, and the amino-modified Ag nanoparticles aqueous dispersion was obtained after ultrasonic treatment at a power of 500 W for 10 min.

[0050] 0.255g of emulsifier P(E / B)-PEO was weighed and dissolved in 25.5g of n-hexadecane to obtain an emulsifier solution. 0.37g quaternized chitosan and 8.0mg Na 2 SO 4Dissolved in 2.0 g of purified Ag nanoparticle aqueous dispersion (wherein the amino-modified Ag nanoparticle content...

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Abstract

A preparation method of antibacterial quaternized chitosan / Ag hybrid nano-hydrogel, said method comprising the following steps: (1) carrying out amino modification of Ag nanoparticles to obtain amino-modified Ag nanoparticles water Dispersion liquid; (2) chitosan is modified with 2,3-epoxypropyltrimethylammonium chloride to obtain quaternized chitosan; (3) emulsifier is dissolved in non-polar solvent to obtain Nonpolar emulsifier solution; (4) hydrophilic metal salt and quaternized chitosan are dissolved in the Ag nanoparticle aqueous dispersion liquid of amino modification, obtain dispersion A; Then dispersion A is added to nonpolar (5) directly drop the cross-linking agent to the reverse mini-emulsion, and react to prepare the quaternized chitosan / Ag hetero The nano hydrogel is purified and then dispersed in water to obtain its aqueous dispersion. The prepared hybrid nano-hydrogel has the advantages of good dispersibility, controllable particle size, good colloidal stability, and broad-spectrum antibacterial properties.

Description

(1) Technical field [0001] The invention relates to a preparation method of antibacterial quaternized chitosan / Ag hybrid nanometer hydrogel. (2) Background technology [0002] The variety and quantity of pathogenic bacteria and the emergence of drug-resistant bacteria caused by the abuse of antibiotics are a serious threat to human health and safety. Therefore, there is an urgent need for safe, efficient, drug-resistant and degradable antibacterial materials. [0003] Chitosan has the characteristics of wide source, good biocompatibility and biodegradability, and is a potential antibacterial candidate material. The antibacterial ability of unmodified chitosan is often weak, which is not enough to meet the complex and changeable antibacterial needs. 247, 116754-116765.]. Ag nanoparticles are favored for their broad-spectrum, high-efficiency, and low-resistance antibacterial properties. However, Ag nanoparticles have problems such as easy agglomeration and difficult processi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08K9/04C08K3/08
CPCC08J3/075C08J3/24C08J2305/08C08K9/04C08K2003/0806
Inventor 曹志海高峰姚俊秘一芳郑思佳
Owner ZHEJIANG SCI-TECH UNIV
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