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Lactobacillus crispatus and its application in the production of products that improve the human vaginal environment

A product and human body technology, applied in the field of medical microorganisms, can solve the problems of functional differences of strains, differences in colonization ability, poor improvement effect, etc., and achieve the effect of broad market prospects and strong acid production ability

Active Publication Date: 2022-02-22
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to functional differences and differences in colonization ability between different strains, there have been cases where the improvement effect is not good

Method used

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  • Lactobacillus crispatus and its application in the production of products that improve the human vaginal environment
  • Lactobacillus crispatus and its application in the production of products that improve the human vaginal environment
  • Lactobacillus crispatus and its application in the production of products that improve the human vaginal environment

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Embodiment Construction

[0030] The present application will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0031] Preparation of strains

[0032] Lactobacillus crispatus (Lactobacillus crispatus, Lc-17217) of the present application is obtained by separation method, and concrete steps are as follows:

[0033] The vaginal secretions of healthy people were collected with disposable sterile swabs, inoculated on MRS medium by direct coating method, and cultured anaerobically at 37°C for 18-27 hours to obtain multiple colonies;

[0034] Separately extract the DNA of multiple single colonies, amplify and measure the 16S rDNA sequence of the single colony, compare the measurement results with the 16S rDNA sequence of Lactobacillus, and obtain the strain of the present application through a series of functional experiments , the bacterial strain is Lactobacillus crispatus (Lactobacillus crispatus, Lc-17217) capable of improving the human vagina...

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Abstract

The present application discloses a bacterial strain, which is a strain of Lactobacillus crispatus (Lc-17217), and the preservation number is CGMCC No. 21221. Compared with other Lactobacillus crispatus of the same species, the strains of the present application have stronger acid production capacity, hydrogen peroxide production capacity and value-added capacity. The strains of the present application can inhibit the growth of various pathogenic bacteria and can inhibit vaginal Gardnerella, Micrococcus flavum, and Prevotella have broad market prospects.

Description

technical field [0001] The present application relates to the technical field of medical microorganisms, in particular to a lactobacillus crispatus and its application in the production of products for improving the human vaginal environment. Background technique [0002] The human female vaginal environment refers to the micro-ecological environment composed of all the microbial groups living in the female vaginal cavity. Under normal circumstances, a large number of microorganisms reside in the female vaginal cavity, and these microorganisms play an important role in the local microenvironment to maintain the health of the female vagina. Studies have shown that there are significant differences in the vaginal microbes of women of different ages. It is shown that before puberty, the typical characteristics of female vaginal flora are low abundance of Lactobacillus, Gardnerella vaginalis and R. With the onset of puberty, the vaginal epithelium thickens again, stimulated by ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747A61P15/02A61P31/04A61P31/10C12R1/225
CPCA61K35/747A61K9/0053A61K9/0034A61K9/0014A61P15/02A61P31/04A61P31/10
Inventor 周宏伟陈慕璇
Owner ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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