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Novel medicine for preventing and treating heart disease

A heart disease and drug technology, applied in the field of medicine, can solve plaque instability and other problems, and achieve the effects of inhibiting platelet activation, preventing cardiomyopathy, and inhibiting cell proliferation

Pending Publication Date: 2021-08-24
张建强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, these risk factors can also lead to plaque instability, eventually leading to angina and even acute myocardial infarction

Method used

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  • Novel medicine for preventing and treating heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: A kind of novel prevention and treatment medicine of heart disease, this medicine is used for preventing coronary heart disease, and medicine is made unconjugated bilirubin capsule, and unconjugated bilirubin capsule comprises 3mg bilirubin and 1ml olive oil .

Embodiment 2

[0035]Embodiment 2: A kind of novel prevention and treatment medicine of heart disease, this medicine is used for treating coronary heart disease and preventing restenosis of coronary artery lumen, medicine is made unconjugated bilirubin capsule, and unconjugated bilirubin capsule contains 10mg bilirubin and 1ml fish oil.

Embodiment 3

[0036] Embodiment 3: A kind of novel prevention and treatment medicine of heart disease, this medicine is used for acute coronary syndrome, and medicine is made unconjugated bilirubin capsule, and unconjugated bilirubin capsule comprises 60mg bilirubin and 1ml olive oil.

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PUM

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Abstract

The invention discloses a novel medicine for preventing and treating heart diseases, the main component of the medicine is non-binding bilirubin, and the medicine is used for preventing the heart diseases, further reducing the incidence of the heart diseases, reducing sudden death or heart failure, improving the life quality of patients with the heart diseases and improving the prognosis. The non-binding bilirubin has stronger effects of resisting oxidation, resisting inflammation, inhibiting cell proliferation, inhibiting platelet activation, promoting cholesterol metabolism and the like, and can achieve the effects of preventing atherosclerosis, protecting vascular endothelial cells and smooth muscle cells, protecting myocardium, preventing lipid deposition, reducing atheromatous plaque formation and reducing myocardial damage. In view of low water solubility of the unbound bilirubin, the oral unbound bilirubin is mixed with the olive oil or the fish oil to be stored in the capsule, so the absorption of the unbound bilirubin can be promoted, and the bilirubin can be protected from being oxidized.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a novel medicine for preventing and treating heart disease. Background technique [0002] Coronary artery stenosis caused by coronary atherosclerosis is the main cause of coronary heart disease. Ischemic cardiomyopathy caused by coronary heart disease and dilated heart disease triggered by peroxidation are the most common clinical causes of sudden death. And these cardiomyopathies will eventually progress to the advanced stage of heart disease---heart failure, about 50% of heart failure patients have an ejection fraction ≤40%, and the 5-year mortality rate of this part of heart failure patients is 50%, 10 years The case fatality rate can reach 90%. Risk factors such as high blood pressure, diabetes, smoking, and drinking can increase the body's inflammation and oxidative state. Inflammation and peroxidation can stimulate coronary artery endothelial hyperplasia, smoo...

Claims

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Application Information

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IPC IPC(8): A61K31/409A61K9/48A61P9/10
CPCA61K31/409A61K9/4858A61P9/10
Inventor 张建强
Owner 张建强
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