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Preparation method of vitex oil preparation

A vitex oil and preparation technology, which can be applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve problems such as reducing patient experience, weakening efficacy, and delaying disintegration. , to meet the requirements of active ingredients and clinical treatment, promote absorption in the body, and reduce safety problems

Active Publication Date: 2021-08-31
GUANGZHOU XINGQUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two inventions have simplified the process to a certain extent, and at the same time ensured the stability and quality of the product, but the addition of some of the above-mentioned auxiliary materials may weaken its efficacy due to the reduction in the content of Vitex oil, resulting in the elimination of phlegm. , cough, asthma or chronic bronchitis in the course of treatment need to take a lot of proprietary medicines to reduce the patient's sense of experience
At the same time, the stability of the Vitex oil nanoemulsion in the latter patent is difficult to guarantee. At the same time, the emulsion also has difficulties in storage and is easily attacked by bacteria and fungi, which leads to mold problems.
[0004] Aiming at problems such as adhesion, mildew, delayed disintegration, poor efficacy of the preparation, cumbersome preparation process and high production cost in the production and storage process of the preparation method of Vitex oil preparation in the prior art, it is urgent to find a preparation method of Vitex oil preparation , which can effectively solve the above problems

Method used

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  • Preparation method of vitex oil preparation
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  • Preparation method of vitex oil preparation

Examples

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Embodiment 1

[0024] A preparation method of vitex oil preparation, characterized in that: comprising the following steps:

[0025] Heat the medicinal base to melt, add vitex oil for the first time, heat again to 50°C after cooling, keep for 10 minutes and add vitex oil for the second time, mix well and cool to get the product;

[0026] Among them, the medicinal base includes by weight parts: 10 parts of polyethylene glycol, 5 parts of poloxamer, 2 parts of β-cyclodextrin, 1 part of arachidonic acid oil, 0.5 parts of sodium lauryl sulfate , 0.5 parts Tween-80 and 1 part calcium beta-hydroxy-beta-methylbutyrate. The weight ratio of the first addition of Vitex oil to the second addition of Vitex oil is 2:1, and the weight ratio of the total weight of Vitex oil to the medicinal base is 1:2.

Embodiment 2

[0028] A preparation method of vitex oil preparation, characterized in that: comprising the following steps:

[0029] Heat the medicinal base to melt, add vitex oil for the first time, heat again to 60°C after cooling, keep for 10 minutes and add vitex oil for the second time, mix well and cool to get the product;

[0030] Among them, the medicinal base includes by weight parts: 15 parts of polyethylene glycol, 8 parts of poloxamer, 5 parts of β-cyclodextrin, 2.5 parts of arachidonic acid oil, 1.5 parts of sodium lauryl sulfate , 0.8 parts Tween-80 and 2 parts calcium β-hydroxy-β-methylbutyrate. The weight ratio of the first addition of Vitex oil to the second addition of Vitex oil is 3:1, and the weight ratio of the total weight of Vitex oil to the medicinal base is 1:8.

Embodiment 3

[0032] A preparation method of vitex oil preparation, characterized in that: comprising the following steps:

[0033] Heat the medicinal base to melt, add vitex oil for the first time, heat again to 55°C after cooling, keep for 12 minutes and add vitex oil for the second time, mix well and cool down to get the product;

[0034] Among them, the medicinal base includes by weight parts: 12 parts of polyethylene glycol, 6 parts of poloxamer, 3 parts of β-cyclodextrin, 2 parts of arachidonic acid oil, 1 part of sodium lauryl sulfate , 0.6 parts of Tween-80 and 1.5 parts of calcium β-hydroxy-β-methylbutyrate. The weight ratio of the first addition of Vitex oil to the second addition of Vitex oil is 2.5:1, and the weight ratio of the total weight of Vitex oil to the medicinal base is 1:5.

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Abstract

The invention provides a preparation method of a vitex oil preparation, and relates to the field of pharmacy. The preparation method of the vitex oil preparation comprises the following steps: heating a medicinal matrix until the medicinal matrix is molten; adding vitex oil by batches; and then, carrying out uniform mixing and cooling to obtain the vitex oil preparation. The medicinal matrix is composed of polyethylene glycol, poloxamer, beta-cyclodextrin, arachidonic acid grease, lauryl sodium sulfate, tween-80 and calcium beta-hydroxy-beta-methylbutyrate. The finally prepared vitex oil preparation is not liable to mildew and age, can be quickly dissolved and dispersed, and can well meet requirements of medicinal composition property and clinical treatment.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a preparation method of vitex oil preparation. Background technique [0002] Vitex oil is the volatile oil extracted from Vitex Verbenaceae. It is a light yellow or orange clear liquid. It has the functions of expectorant, cough and asthma, and has a good curative effect on chronic bronchitis. At present, researchers have successively developed preparations in dosage forms such as capsules and dripping pills, using vitex oil as the main medicine. However, the current vitex oil preparations of various dosage forms usually have problems such as adhesion, mildew, delayed disintegration or poor efficacy of the preparation during production and storage, and additional plasticizers, colorants, preservatives and other auxiliary materials are added. Stability and shelf life are long, but there are also problems of cumbersome preparation steps and high cost. [0003] In view of the above problem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/12A61K47/10A61K36/85A61P11/00A61P11/10A61P11/14A61P11/06
CPCA61K47/12A61K47/10A61K36/85A61P11/00A61P11/10A61P11/14A61P11/06
Inventor 梁贝尔黄翠勤万安凤钟小天黄志云黎志坚
Owner GUANGZHOU XINGQUN PHARMA