Perampanel orally disintegrating tablet and preparation method thereof
A technology for disintegrating tablets and disintegrating agents is applied in the field of perampanel orally disintegrating tablets, which can solve problems such as inconvenience in swallowing, and achieve the effects of easy popularization and simple preparation process.
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Embodiment 1
[0026] Example 1:
[0027] Perampanel 2%
[0028] Dextrin 26%
[0029] Mannitol 40%
[0030] Lactose 20%
[0031] Low-substituted hydroxypropyl cellulose (L-HPC) 8%
[0032] Aspartame 2%
[0033] Talc 1.5%
[0034] Magnesium Stearate 0.5%
[0035] The dosage form can be produced by using conventional tablet pharmaceutical equipment and prepared by a compression process. The specific preparation method is as follows: micronize perampanel and pass through a 100-mesh sieve; pulverize aspartame and pass through a 80-mesh sieve, Weigh it, mix it with the raw material drug evenly, and pass the dextrin, mannitol, lactose, low-substituted hydroxypropyl cellulose, talcum powder, and magnesium stearate through an 80-mesh sieve respectively, weigh it according to the prescription amount, and mix it evenly. Then mix with perampanel mixed with aspartame, sieve and mix evenly, measure the content of the semi-finished product, calculate the weight of the tablet, compress the tablet, t...
Embodiment 2
[0038] Perampanel 2%
[0039] Lactose 38%
[0040] Mannitol 41%
[0041] Low-substituted hydroxypropyl cellulose (L-HPC) 8%
[0042] Croscarmellose Sodium (CCNa) 2.5%
[0043] Aspartame 2.5%
[0044] Strawberry flavor 2.0%
[0045] Sweet Orange Flavor 2.0%
[0046] Talc 1.5%
[0047] Magnesium Stearate 0.5%
[0048] The dosage form can be produced by conventional tablet pharmaceutical equipment and prepared by a compression process. The specific preparation method is as follows: micronize perampanel and pass through a 100-mesh sieve; aspartame, strawberry essence, and sweet orange essence are separately Crush and pass through an 80-mesh sieve, weigh according to the prescription amount, mix evenly with the raw material drug, and separately pass lactose, mannitol, low-substituted hydroxypropyl cellulose, croscarmellose sodium, and magnesium stearate through an 80-mesh sieve , respectively weighed according to the prescription amount, mixed evenly, then mixed with peramp...
Embodiment 3
[0051] Perampanel 2%
[0052] Lactose 44%
[0053] Mannitol 40%
[0054] Sodium Carboxymethyl Starch (CMS-Na) 3%
[0055] Stevioside 3%
[0056] Peppermint Flavor 1.5%
[0057] Strawberry flavor 2.0%
[0058] Sweet Orange Flavor 2.0%
[0059] Talc 1.5%
[0060] Magnesium Stearate 1.0%
[0061] The dosage form can be produced by conventional tablet pharmaceutical equipment and prepared by pressing technology. The specific preparation method is as follows: micronize perampanel and pass through a 100-mesh sieve; mix stevioside, strawberry essence, sweet orange essence, and mint essence Grind and pass through 80-mesh sieve respectively, weigh according to the prescription quantity, and mix evenly with the raw material drug, and separately pass lactose, mannitol, sodium carboxymethyl starch, and magnesium stearate through 80-mesh sieve, weigh according to the prescription quantity, and mix uniform, and then mixed with perampanel mixed with stevioside, etc., sieved and mixed...
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