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Application of epimedin C in prevention and treatment of acute alcoholism

A technology for alcoholism and epimedium, which is applied in the field of biomedicine, can solve the problems of no application of epimedin C for preventing and treating acute alcoholism, unclear molecular mechanism of action mechanism, influence on technical reliability and practicability, and the like, Achieve the effect of prolonging the incubation period of drunkenness, easy analysis, detection and quality control, and significant control effect

Active Publication Date: 2021-10-01
SHAANXI NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (3) At present, the drug application of Epimedin C is mainly concentrated in the fields of osteoporosis, cancer, immunocompromised, menopausal syndrome, diabetic liver injury, etc. There is no report on the application of Epimedin C in the prevention and treatment of acute alcoholism
[0009] (4) Many existing technologies lack experimental basis, and the mechanism of action, especially the molecular mechanism (such as proteomic analysis), is not clear, which affects the credibility and practicability of the technology

Method used

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  • Application of epimedin C in prevention and treatment of acute alcoholism
  • Application of epimedin C in prevention and treatment of acute alcoholism
  • Application of epimedin C in prevention and treatment of acute alcoholism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: Preparation of Epimedin C Aerosol

[0045] Active ingredient: Epimedin C;

[0046] Main excipients: film forming agent (hydroxypropyl methylcellulose), liquid paraffin, propellant (propane butane), chitosan;

[0047] Preparation process: take epimedin C (molecular formula: C 39 h 50 o 19 ; CAS No.: 110642-44-9; Batch No.: 111780-201905; provided by China Institute for Food and Drug Control) and (65±3)% ethanol solution according to the solid-liquid ratio of 1:3 to 1:4, mix and infiltrate, airtight Stand for 23 to 25 hours, concentrate with a rotary evaporator, filter the concentrated solution with a microporous membrane (0.45 μm), take the filtrate and add (2.0±0.1)% chitosan solution and appropriate amount of liquid paraffin (tested in advance). The mixed solution and the propellant can be packed according to the ratio of 1:8 to 1:10 to obtain Epimedin C aerosol.

Embodiment 2

[0048] Embodiment 2: Preparation of Epimedin C Nanoparticles

[0049] Active ingredient: Epimedin C;

[0050] Main excipients: ethyl cellulose;

[0051] Preparation process: dissolve ethyl cellulose in ethanol to obtain (2.0±0.1)% ethyl cellulose solution. Add an appropriate amount of Epimedin C (pre-tested addition amount), use a high-speed disperser to disperse for 2 to 4 minutes, and homogenize once under pressures of 50MPa, 70MPa and 90MPa to obtain an organic phase solution. Make the organic phase solution into an emulsion, concentrate and remove ethanol with a rotary evaporator at (40±5)°C, then vacuum freeze-dry, vacuumize the suspension after dispersion, fill nitrogen to atmospheric pressure, and pre-cool to ( 8±1)°C, vacuum again after 1 hour, and then lower the temperature to freeze the solution into an ice-like solid. After 3 to 5 hours, nitrogen gas is introduced, and the temperature is kept for 5 to 7 hours. Finally, the Epimedin C nanoparticle agent was prepar...

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Abstract

The invention discloses an application of epimedin C in prevention and treatment of acute alcoholism, and belongs to the technical field of biological medicine. The invention discloses that the epimedin C can shorten the sobering time and sleepiness time of an acute alcoholism model animal, prolong the drunkenness latency period, reduce the levels of total bilirubin, total cholesterol and triglyceride in serum, reduce the activity levels of glutamic-pyruvic transaminase and glutamic oxalacetic transaminase in serum, increase the content of reduced glutathione, reduce the content of malondialdehyde, can maintain normal forms and structures of liver tissues and cells, regulate proteome expression of acute alcoholism animals, repair damage of nervous systems, improve oxidative stress states of organisms and improve glycometabolism and lipid metabolism, so that the epimedin C can be used for preparing drugs for preventing and treating acute alcoholism. The epimedin C is used for preparing a medicine for preventing and treating acute alcoholism in the form of a medicinal preparation such as aerosol and the like. The invention is helpful for promoting the research and development process of acute alcoholism prevention and treatment medicines, and also provides a thought for development and utilization of epimedium resources.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, relates to the new effect of epimedin C in preventing and treating acute alcoholism, and specifically relates to its application in the preparation of medicines for preventing and treating acute alcoholism. Background technique [0002] One-time intake of excessive drinking alcohol (including liquor, beer, wine, rice wine and other fermented wine, distilled wine and prepared wine) or alcohol (ethanol) may cause acute alcohol poisoning, resulting in behavioral actions (such as ataxia ), consciousness nerves (such as coma), metabolic stress (such as glucose metabolism, oxidative stress), tissues and organs (such as stomach, esophagus, liver, pancreas, brain damage), molecular cells (such as apoptosis), etc. Abnormalities or lesions that may be life-threatening in severe cases. Acetaldehyde produced by alcohol metabolism can cause stem cell mutation and chromosomal damage (see Alcohol and endog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/296A61K9/12A61P39/02
CPCA61K31/7048A61K36/296A61P39/02A61K9/12
Inventor 张华峰张梦园杨晓华梁巧
Owner SHAANXI NORMAL UNIV
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