Soothing and repairing composition and preparation method thereof

A composition and soothing technology, applied in the directions of drug combinations, skin care preparations, pharmaceutical formulations, etc., can solve the problems of skin barrier damage of sensitive skin, unsuitable for sensitive skin people, and inability to achieve the addition amount, etc. red, lifting effect, reducing effect of high reactivity

Active Publication Date: 2021-10-08
西安德诺海思医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In actual experiments, it was found that the above-mentioned active ingredients could not be added in an amount of 20mg / ml at room temperature at 25°C, and crystals would precipitate out. If you want to add a high content to the product, you need a large amount of polar solvents, such as dipropylene glycol , DMSO, which is difficult to apply in the actual development process of the formula, and because the active ingredient is slightly soluble in water or insoluble in water, it is necessary to add a higher content of ethanol or DMSO and other polar solutions, such solvents will make sensitive skin The skin barrier damage of people with sensitive skin is more serious, and this solution is difficult to apply to the formulation development of skin care products, and it is not suitable for the skin characteristics of sensitive skin groups

Method used

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  • Soothing and repairing composition and preparation method thereof
  • Soothing and repairing composition and preparation method thereof
  • Soothing and repairing composition and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] A soothing and repairing composition: comprising the following raw materials in parts by weight: 0.5 part of tetrahydrocurcumin, 0.1 part of paeonol, 0.5 part of glycyrrhizic acid, 0.01 part of licorice extract, 0.5 part of bisabolol, 4-tert 0.5 part of butylcyclohexanol, 0.5 part of panthenol, and 0.1 part of water-soluble protein; the extract of Glycyrrhiza inflate is crushed into coarse powder, soaked in 80% ethanol solution for 0.5h by volume fraction and then used above 6 The ethanol solution with twice the volume is heated and refluxed once, for 1 hour each time, filtered, and the filtrates are combined to obtain the extract, which is concentrated and left standing. Collagen, 90% pure.

Embodiment 2

[0031] A soothing and repairing composition: comprising the following raw materials in parts by weight: 2.5 parts of curcumin, 0.1 part of paeonol, 3 parts of 18β-glycyrrhetinic acid, 1 part of licorice extract, 10 parts of bisabolol, 4- 10 parts of tert-butylcyclohexanol, 20 parts of panthenol, and 0.002 parts of water-soluble protein; the extract of Glycyrrhiza inflate is crushed into coarse powder, soaked in ethanol solution with a volume fraction of 95% for 2 hours, and then used above 12 The volume-fold ethanol solution was heated and refluxed for 3 times, each time for 3 hours, filtered, and the filtrates were combined to obtain the extract, which was concentrated and left to stand. After the obtained precipitate was dried, it was the extract of Glycyrrhiza inflata, and the water-soluble protein was type III Collagen, 98% pure.

Embodiment 3

[0033] A soothing and repairing composition, comprising the following raw materials in parts by weight: 1.2 parts of tetrahydrocurcumin, 0.05 parts of paeonol, 0.2 parts of glycyrrhizic acid, 0.6 parts of licorice extract, 6 parts of bisabolol, 4-tert 6 parts of butylcyclohexanol, 12 parts of panthenol, and 1.5 parts of water-soluble protein. The extract of Glycyrrhiza inflate is that Glycyrrhiza inflate is crushed into coarse powder, soaked in 90% ethanol solution for 1.5h by volume fraction and then used above 10 parts. Ethanol solution twice the volume is heated and refluxed for extraction twice, each time for 2 hours, filtered, and the filtrates are combined to obtain the extract, concentrated and left to stand, and the obtained precipitate is dried, which is the extract of Glycyrrhiza inflata, and the water-soluble protein is mussel Mucin, 95% pure.

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Abstract

The invention provides a soothing and repairing composition and a preparation method thereof. The soothing and repairing composition is prepared from the following raw materials in parts by weight: 0.5 to 3.0 parts of tetrahydrocurcumin or curcumin, 0.01 to 0.5 part of paeonol, 0.01 to 3 parts of glycyrrhizic acid or 18 beta-glycyrrhetinic acid, 0.01 to 1 part of an extract of Glycyrrhiza inflata Bat., 0.1 to 10 parts of bisabolol, 0.2 to 10 parts of 4-tert-butyl cyclohexanol, 0.5 to 20 parts of panthenol and 0.001 to 1.5 parts of water-soluble protein, wherein the purity of the water-soluble protein is 90 to 98%. According to the soothing and repairing composition provided by the invention, the ratio is adjusted; a soothing agent dissolved by the water-soluble protein and polyol is used; a mixing technology of the soothing agent and a water-soluble protein solution is improved; under a proper stirring condition, the temperature is controlled so that the soothing agent dissolved by the polyol and the water-soluble protein can be dissolved very well and are not separated out, and the effect of the composition is facilitated; the soothing and repairing composition can be used for soothing subjective symptoms including inflammation, stabbing pain and the like and has a relatively strong anti-allergic effect; and effective active components in the composition are scientifically proportioned and have a synergistic effect.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a soothing and repairing composition and a preparation method thereof. Background technique [0002] According to the consensus of Chinese experts on the diagnosis and treatment of sensitive skin, sensitive skin has a high incidence in all countries in the world. The probability of sensitive skin in Asian women is 40%-55.98%, and that of Chinese women is about 36.1%, which means that 1 out of every 3 women will be troubled by sensitive skin. With the increasing environmental pollution, increasing mental stress and improper skin care methods, the incidence rate is gradually increasing, and more and more people pay more and more attention to it. [0003] The definition of sensitive skin in the 2017 "Expert Consensus on Diagnosis and Treatment of Sensitive Skin" is a hyperreactive state of the skin under or under pathological conditions, manifested as being stimulated by physical, chemical...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/34A61K8/35A61K8/42A61K8/63A61K8/64A61K8/65A61K8/66A61P37/08A61Q19/00
CPCA61K8/9789A61K8/35A61K8/63A61K8/34A61K8/42A61K8/64A61K8/66A61K8/65A61Q19/005A61P37/08A61K2800/30Y02A50/30
Inventor 刘影杨晓萍
Owner 西安德诺海思医疗科技有限公司
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