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Colon cancer intestinal microecology accurate detection, evaluation and intervention system and method

A technology of intestinal microecology and colon cancer, which is applied in the medical field, can solve the problems of inconspicuous symptoms of colon cancer, the inability to carry out accurate corresponding treatment and prevention, and easy deviations in diagnosis and treatment, so as to reduce the incidence of infectious complications, easy to operate, The effect of high DNA purity

Pending Publication Date: 2021-10-08
QIANFOSHAN HOSPITAL OF SHANDONG +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the deficiencies of the prior art, the present invention discloses a system and method for precise detection, evaluation and intervention of intestinal microecology of colon cancer, which are used to solve the problem that early colon cancer symptoms are not obvious, and the diagnosis and treatment tend to be biased, and precise corresponding treatment and prevention cannot be carried out;

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  • Colon cancer intestinal microecology accurate detection, evaluation and intervention system and method
  • Colon cancer intestinal microecology accurate detection, evaluation and intervention system and method

Examples

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Embodiment 1

[0028] This embodiment discloses a precise detection and evaluation intervention system for intestinal microecology of colon cancer, please refer to figure 1 , including an acquisition unit 1 and a cancer assessment unit 2, the cancer assessment unit 2 including a processing unit 3 and an assessment establishment unit 4; the acquisition unit 1 screens and extracts the intestinal flora of colon cancer patients and healthy people at different stages, And send the extracted pathological data to the initial integration unit 5 of the processing unit 3 for integration; the initial integration unit 5 identifies the colon cancer patient and the healthy person without cancer, and based on metagenomics and The calculated discriminant value was validated by the population to determine the detection method of intestinal flora.

[0029] Obtain the biomarkers related to colon cancer in the colon cancer group according to the analysis unit 6, and obtain the flora imaging map of the colon can...

Embodiment 2

[0036] This embodiment discloses a precise detection and evaluation intervention method for colon cancer intestinal microecology, which is used to realize the precise detection and evaluation intervention system for colon cancer intestinal microecology described in Example 1. see figure 2 , the steps of the method are as follows:

[0037] S1. Screening and extracting the intestinal flora of patients with different stages of colon cancer and healthy people;

[0038] S2. Obtain colon cancer-related intestinal bacteria by culturing the intestinal flora;

[0039] S3. Obtain colon cancer-related biomarkers through high-throughput analysis;

[0040] S4. After metagenomics and population verification, establish an accurate and efficient intestinal flora detection method that can be used for early diagnosis of colon cancer;

[0041] S5. Output the three-dimensional medical images of the flora imaging images of the colon cancer group and the healthy control group;

[0042] S6. Con...

Embodiment 3

[0057] This example provides a method for the precise detection and evaluation of colon cancer intestinal microecology in Example 2, and also discloses the elimination of uncertain factors in the changes in the colon cancer group and the healthy control group. Cancer is closely related to changes in the intestinal environment caused by eating habits, and intestinal flora is an important factor that constitutes the intestinal environment. Bacteria in feces include aerobic bacteria, anaerobic bacteria and facultative anaerobic fungi, etc., about 99% For anaerobic bacteria, there are a small amount of Aerobacillus, Proteus, Bacillus and yeast.

[0058] In this embodiment, the ratio of bifidobacteria / Escherichia coli represents the quantity ratio of anaerobic bacteria and aerobic bacteria. When a significant increase in Escherichia coli and a significant decrease in Bifidobacteria were detected in patients with colon cancer, the ratio of the numbers of anaerobic and aerobic bacter...

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Abstract

The invention relates to the technical field of medical treatment, in particular to a colon cancer intestinal microecology accurate detection, evaluation and intervention system and method. The system comprises an acquisition unit and a cancer evaluation unit, and the cancer evaluation unit comprises a processing unit and an evaluation establishment unit. The method comprises the following steps: screening and extracting, by the acquisition unit intestinal flora of colon cancer patients at different stages and healthy people, and sending extracted pathological data to an initial integration unit of the processing unit for integration; obtaining biomarkers related to colon cancer in a colon cancer group according to an analysis unit, and obtaining flora imaging pictures of the colon cancer group and a healthy control group through an imaging unit; and constructing, by a model establishment unit, an accurate evaluation model of colon cancer intestinal flora imbalance according to the flora imaging pictures. The method solves the problems that an early colon cancer symptom is not obvious, diagnosis and treatment are easy to cause deviation, and accurate corresponding treatment and prevention cannot be carried out.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a system and method for precise detection, evaluation and intervention of colon cancer intestinal microecology. Background technique [0002] Colon cancer is one of the nine common malignant tumors in my country, and its incidence rate ranks third among gastrointestinal tumors. In my country, among the deaths due to colon cancer, males rank fifth among malignant tumor deaths, and females rank sixth. Colon cancer is mainly adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma. The general shape is polypoid, ulcerous and so on. Patients with chronic colitis, patients with colon polyps, and obese men are susceptible groups. Most patients have good curative effects before and after surgery, radiotherapy and chemotherapy, and comprehensive treatment of traditional Chinese medicine. [0003] Colorectal cancer is one of the common malignant tumors, including colon can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H10/40G16H50/30
CPCG16H10/40G16H50/30Y02A90/10
Inventor 李岩梁婧解奇李俊伟王宣秦楠
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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