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Preparation method of gamma-PGA nanofibers

A nanofiber, hyperbranched polyamide technology, applied in the field of preparation of γ-PGA nanofibers, can solve the problems of small draw ratio, low draw rate, low yield, etc., and achieves improvement of fiber water stability and accelerated removal Efficiency, the effect of broad application space

Active Publication Date: 2021-10-12
苏州合祥纺织科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large frictional resistance of the liquid coagulation bath, the drawing rate is relatively low, the drawing ratio is also small, and the yield is low, the diameter of the fiber obtained by air-jet spinning often cannot meet the demand

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of γ-PGA nanofibers, the specific process steps are as follows:

[0024] (1) Diethylenetriamine and methyl acrylate are used as raw materials to synthesize monomers through micheal addition reaction, and then the monomers undergo their own melt polycondensation reaction under high temperature conditions to obtain hyperbranched polyamide-amine.

[0025] (2) Dissolve the above hyperbranched polyamidoamine in methanol to obtain a methanol solution of hyperbranched polyamidoamine, add a certain amount of γ-PGA and 1-ethyl-(3-dimethylaminopropyl) Carbodiimide hydrochloride (EDC.HCl), additional solvent DMSO, mixed reaction for 72 hours, and then dialyzed to obtain spinning solution;

[0026] (3) Utilize the syringe pump to feed the spinning solution obtained in step (2) into the spinneret box body through the metering pump at a speed of 11mL / h, and the spinning solution forms a thin stream when it is extruded from the spinneret, and simultaneously Compr...

Embodiment 2

[0034] A preparation method of γ-PGA nanofibers, the specific process steps are as follows:

[0035] (1) Diethylenetriamine and methyl acrylate are used as raw materials to synthesize monomers through micheal addition reaction, and then the monomers undergo their own melt polycondensation reaction under high temperature conditions to obtain hyperbranched polyamide-amine.

[0036] (2) Dissolve the above hyperbranched polyamidoamine in methanol to obtain a methanol solution of hyperbranched polyamidoamine, add a certain amount of γ-PGA and 1-ethyl-(3-dimethylaminopropyl) Carbodiimide hydrochloride (EDC.HCl), added solvent DMSO, mixed reaction for 48 hours, and then dialyzed to obtain spinning solution;

[0037] (3) Utilize the syringe pump to feed the spinning solution obtained in step (2) into the spinneret box body through the metering pump at a speed of 11mL / h, and the spinning solution forms a thin stream when it is extruded from the spinneret, and simultaneously Compressed...

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Abstract

The invention provides a preparation method of gamma-PGA nanofibers. The preparation method comprises the following steps of preparing fibers by adopting a jet spinning method, carrying out sufficient water stabilization modification on the obtained modified gamma-PGA nanofibers, generating a liquid vortex by a bottom stirring device in a coagulating bath, enabling jet trickles to enter the coagulating bath from the center of the vortex, wherein the fibers are fully crosslinked, and the diameter meets the requirement, so that the obtained gamma-PGA nanofiber has water stability and good applicability.

Description

technical field [0001] The invention belongs to the field of nanofibers, in particular to a method for preparing gamma-PGA nanofibers. Background technique [0002] γ-polyglutamic acid (γ-PGA) is a natural polymer material synthesized by microorganisms. In mammals, γ-PGA can be degraded into harmless glutamic acid by γ-polyglutamic acid transpeptidase. A large number of studies have shown that γ-PGA is a polymer material with good biodegradability, biocompatibility, and non-toxic to humans and the environment. In the field of medicine, γ-PGA can realize the sustained release of drugs, improve the water solubility of drugs, reduce adverse drug reactions, and improve the efficacy of drugs. [0003] γ-PGA fibers can be widely used in the field of biomedicine after being spun into fibers, but γ-PGA fibers alone are easy to degrade in water and have poor water stability, which limits some of their applications. In the prior art, γ-PGA is usually chemically modified to improve ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/80D01F11/08D01D1/02D01D5/04D01D5/06
CPCD01F6/80D01F11/08D01D1/02D01D5/04D01D5/06Y02P20/10
Inventor 张兴光王威徐正东陈星鄢军
Owner 苏州合祥纺织科技有限公司
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