A kind of composition, granule and preparation method for treating nephropathy
A composition and granule technology, which is applied in the field of traditional Chinese medicine composition, can solve the problem of lack of DKD progress drugs, etc., and achieve the effect of improving the molding rate
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preparation example Construction
[0049] The present invention also provides the preparation method of the above-mentioned granules for the treatment of kidney disease, comprising the following steps:
[0050] S1, the preparation of extract: mix the Astragalus membranaceus, the meat of Radix Glycyrrhizae, Bupleurum, Angelica sinensis, Dodder and silkworm of formula amount, after adding water to soak, decoct, filter, merge extract, concentrate, obtain extract;
[0051] S2, adding dextrin to the extract obtained in step S1 and mixing, drying and pulverizing to obtain mixed powder;
[0052] The mass ratio of the addition of the dextrin described in the step S2 and the extract is 1:1;
[0053] S3, adding ethanol to the mixed powder obtained in step S2, making wet granules, drying and granulating to obtain the granules;
[0054] The amount of ethanol added in step S3 is 25-40% of the weight of the mixed powder.
[0055] The components of the compositions for treating kidney disease in Examples 1-5 are shown in 2....
experiment example 1
[0070] Experimental example 1. Quality evaluation of granules
[0071] The molding rate and the dissolution rate of the granules prepared in Examples 1-3 and Comparative Examples 3 and 4 were checked for quality, as follows:
[0072] 1. Forming rate
[0073] Take a certain amount of particles and measure them according to the double sieving method under the general rule of the Pharmacopoeia. The particles that can pass through the No. 1 sieve but cannot pass through the No. 5 sieve are qualified particles, weighed, and calculated according to the following method.
[0074] Forming rate = mass of particles that can pass through No. 1 sieve but cannot pass through No. 5 sieve / total weight of particles x 100%.
[0075] 2. Melting rate
[0076] Put 0.50 g of precisely weighed qualified particles into a centrifuge tube with constant weight, accurately add 5 mL of boiling water at 100°C, stir and shake for 5 min. Put it into a centrifuge for 15 minutes, discard the supernatant, d...
experiment example 2
[0082] Experimental Example 2. Evaluation of the effect of treating nephropathy
[0083] 1. Experimental animals
[0084] 135 6-week-old specific pathogen free (SPF) male db / db mice (Lepr) ko / ko and 15 same-week-old male (Lepr) wt / wt mice were purchased from Jiangsu JiCuiYaoKang Biotechnology Co., Ltd., weight 22-50g. Animals were housed in the SPF animal room of the Animal Experiment Center of Jinan University. The daily food intake is 4-6g, free drinking water, 12 hours light / black cycle, constant temperature (24±1) ℃ and constant humidity (45±10)% indoors.
[0085] 2. Drugs and reagents
[0086] Preparation of Luotingxin (10 mg / kg) suspension: add 500 mg of the drug to each 500 ml of normal saline and store at room temperature for later use. Blood glucose test strips and blood glucose meters were purchased from Bayer, Germany. Elisa kits for the detection of serum cystatin C, urinary microalbumin, and urinary creatinine were purchased from Guangzhou Saiguo Biotechnolog...
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