The invention discloses a method capable of improving the quality of a large-section peritectic steel continuous casting billet. The method comprises control over the following processing steps that (1) the chemical ingredients of low-alloy peritectic steel are optimized; (2), after VD treatment, a fed calcium line is controlled to perform final deoxidation and inclusion modification treatment, and soft blowing is performed before casting; (3), full package operation is adopted for a tundish, the tonnage is controlled, and low-liquid-level casting is avoided; (4), the superheat degree of the tundish is controlled in the continuous-casting throwing process, and meanwhile the temperature difference of molten steel between two furnaces is controlled; (5), the fed-water temperature of a crystallizer and the temperature difference between fed water and discharged water are controlled, meanwhile, the narrow edge taper of the crystallizer is increased, and the shrinkage quantity of the peritectic steel is compensated; (6), casting powder special for the peritectic steel is selected, wherein the casting powder is high in alkalinity, low in viscosity and high in melting rate; (7), after thecontinuous casting billet is controlled to enter a secondary cooling zone by 12 meters, electromagnetic stirring is applied, and meanwhile the secondary cooling water amount is lowered. The surface quality and the internal quality of the large-section peritectic steel continuous casting billet cast through the method are both improved to a great extent.