Conductive hydrogel scaffold material for synergistically treating osteosarcoma and promoting bone regeneration as well as preparation method and application of conductive hydrogel scaffold material

A conductive hydrogel and scaffold material technology, which is applied in medical preparations containing active ingredients, wave energy or particle radiation treatment materials, anti-tumor drugs, etc., to achieve tumor recurrence inhibition, excellent photothermal conversion performance, and high-efficiency loading Effect

Active Publication Date: 2021-10-15
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the clinical treatment of malignant bone tumors is still facing challenges

Method used

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  • Conductive hydrogel scaffold material for synergistically treating osteosarcoma and promoting bone regeneration as well as preparation method and application of conductive hydrogel scaffold material
  • Conductive hydrogel scaffold material for synergistically treating osteosarcoma and promoting bone regeneration as well as preparation method and application of conductive hydrogel scaffold material
  • Conductive hydrogel scaffold material for synergistically treating osteosarcoma and promoting bone regeneration as well as preparation method and application of conductive hydrogel scaffold material

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Embodiment Construction

[0032] The technical solutions of the present invention will be further described below in conjunction with the drawings and embodiments.

[0033] The invention provides a conductive hydrogel scaffold material for synergistic treatment of osteosarcoma and promotion of bone regeneration, including: GelMA / Ode hydrogel, PVP-PPy conductive polymer, mechanical performance enhancing particles, and bone growth promoting elements; wherein , according to the mass ratio GelMA / Ode hydrogel: PVP-PPy conductive polymer: mechanical performance enhancing particles: bone growth promoting element = (11 ~ 40): (0.01 ~ 1): (0.5 ~ 2): (0.5 ~ 3 ).

[0034] Optionally, the mechanical property enhancing particles are any one or more of montmorillonite nanoparticles, hectorite nanoparticles, halloysite nanotubes, and sepiolite nanoparticles.

[0035] Optionally, the bone growth-promoting element is any one of strontium and silicon, or a combination of strontium and silicon.

[0036] Methacrylamidat...

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Abstract

The invention discloses a conductive hydrogel scaffold material for synergistically treating osteosarcoma and promoting bone regeneration as well as a preparation method and application of the conductive hydrogel scaffold material. The scaffold material comprises GelMA / Ode hydrogel, a PVP-PPy conductive polymer, mechanical property enhancing particles and bone growth promoting elements, wherein the mass ratio of the GelMA / Ode hydrogel to the PVP-PPy conductive polymer to the mechanical property enhancing particles to the bone growth promoting element is (11-40): (0.01-1): (0.5- 2): (0.5-3). According to the invention, the GelMA / Ode hydrogel, the MMT-Sr particles and the PVP-PPy conductive polymer are polymerized, the GelMA / Ode hydrogel can load drugs, the PVP-PPy conductive polymer has excellent photo-thermal conversion performance, and the material can be used as a preparation material of a scaffold for promoting bone tissue regeneration.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to a conductive hydrogel scaffold material for treating osteosarcoma and promoting bone regeneration, a preparation method and an application thereof. Background technique [0002] Osteosarcoma is the most common primary malignant bone tumor and is a common type of cancer in children and adolescents. Osteosarcoma is a malignant neoplasm of mesenchymal origin, in which malignant spindle-shaped stromal cells produce osteoid tissue. Surgery can directly remove the tumor, but it cannot avoid the recurrence or bone defect caused by osteosarcoma. The rise of combined surgery and chemotherapy has reduced the risk of recurrence in patients with osteosarcoma to some extent. Chemotherapy has long been the standard treatment for osteosarcoma. However, the rapid metabolism of small molecule drugs, side effects of chemotherapy, such as allergies, gastrointestinal toxicity, lead to poor therapeutic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/16A61L27/20A61L27/18A61L27/02A61L27/04A61L27/50A61L27/52A61L27/54A61L27/56A61K41/00A61P35/00C08J3/075C08J3/24C08L89/00C08L79/04
CPCA61L27/222A61L27/16A61L27/20A61L27/18A61L27/025A61L27/047A61L27/50A61L27/52A61L27/54A61L27/56A61K41/0052A61P35/00C08J3/075C08J3/24A61L2300/416A61L2300/412A61L2400/12A61L2300/602C08J2389/00C08J2479/04C08L39/06C08L5/02C08L79/04
Inventor 赵庆华侯田会胡硕吴小峰周承豪王刚阳宋滇文
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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