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Application of fiveleaf akebia fruit extract in preparation of medicine for preventing and/or treating NAFLD

A technology of extracts and drugs, applied in the field of medicine, can solve problems such as increasing the burden on the liver, achieve strong practicability and operability, simple and easy preparation method, or prevent NAFLD induced by high-fat diet

Active Publication Date: 2021-10-22
昆明翔昊科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006]The commonly used drugs for the clinical treatment of NAFLD are statins, which will increase the burden on the liver

Method used

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  • Application of fiveleaf akebia fruit extract in preparation of medicine for preventing and/or treating NAFLD
  • Application of fiveleaf akebia fruit extract in preparation of medicine for preventing and/or treating NAFLD
  • Application of fiveleaf akebia fruit extract in preparation of medicine for preventing and/or treating NAFLD

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1 Preparation of Zha Zha Extract Samples 1-12

[0062] a. Take artificially planted or wild Quza plants, wash away the soil, hang in a ventilated place to dry, separate the underground rhizomes and aboveground stems and leaves, and pulverize them into coarse particles by a pulverizer;

[0063] b. Chopped the underground rhizomes and aboveground stems and leaves respectively, soaked in 75% ethanol for 24 hours, installed percolation column and percolated with 75% ethanol, the percolation flow rate was 20ml / min, and combined the extracts;

[0064] The obtained extract is carried out to high performance liquid chromatography (adopting octadecylsilane bonded silica gel as a chromatographic column of filler; taking methanol-6% acetic acid (19:81) as mobile phase; detection wavelength is 319nm. According to Chinese Pharmacopoeia 2010 version one appendix V high performance liquid chromatography (HPLC) detection, determine the content of each substance in the extract, ...

Embodiment 2

[0070] Example 2: Preparation of Quzha Extract Orally Dispersible Tablets 1-5

[0071] (1) Prescription

[0072]

[0073] (2) Method

[0074] Preparation of Quzha extract inclusion compound: Dissolve the prescribed amount of Quzha extract in 2.5L of 50% ethanol for grinding, add the prescribed amount of hydroxypropyl-β-cyclodextrin, and filter the resulting solution through a microporous membrane until it becomes clear. The clathrate was isolated from the mixture. Add the prescribed amount of hydroxypropyl-β-cyclodextrin, sodium carboxymethyl starch and pregelatinized starch according to the method of equal addition, mix well, add magnesium stearate, mix well, press into tablets, and then the extract of Quzha can be taken orally Dispersible tablets 1-5.

[0075] See the table below for the corresponding relationship between dispersible tablets 1-5 and the Quzha extract used in each dispersible tablet:

[0076] Dispersible tablet number Quza extract sample num...

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PUM

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Abstract

The invention discloses an application of a fiveleaf akebia fruit extract in preparation of a medicine for preventing and / or treating NAFLD. The fiveleaf akebia fruit extract contains at least one of fiveleaf akebia fruit stilbene glucoside or methylpolydatin. The application value of the akebia trifoliata koidz extract rich in the akebia trifoliata koidz stilbene glucoside or the methylpolydatin in the aspect of preventing and treating the non-alcoholic fatty liver disease is found for the first time.

Description

technical field [0001] The application relates to the application of a Quzha extract in the preparation of drugs for the prevention and / or treatment of NAFLD, which belongs to the field of medicine. Background technique [0002] Lipids account for about 5% of liver wet weight in normal human liver. When the accumulation of lipid in liver cells exceeds 5% of the wet weight of the liver, or reaches more than 1 / 3 of the histological area, it is non-alcoholic fatty liver disease (non-alcoholic fatty liverdisease, NAFLD). [0003] NAFLD is a clinical syndrome characterized by diffuse hepatic macrovesicular steatosis without a history of excessive alcohol consumption or other definite liver damage factors. NAFLD disease spectrum includes non-alcoholic simple fatty liver (non-alcoholic fatty liver, NAFL), non-alcoholic steatohepatitis (non-alcoholic steatohepatitis, NASH) and liver cirrhosis (cirrhosis). In recent years, the incidence of NAFLD has been increasing year by year, an...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K31/7034A61K31/05A61P1/16A61K125/00
CPCA61K31/7034A61K31/05A61K36/708A61P1/16A61K2300/00
Inventor 胡琳任杨帆李清清胡群尹开云方震东
Owner 昆明翔昊科技有限公司