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Method and equipment for recovering and purifying MTBE (methyl tert-butyl ether) waste solvent generated by synthesizing drug intermediate

A technology for synthesizing drugs and purification methods, applied in the fields of ether preparation, ether separation/purification, organic chemistry, etc., which can solve the problems of greatly reducing environmental pressure, etc., and achieve the effects of reducing pollution and saving production costs

Inactive Publication Date: 2021-10-22
四川熔增环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the traditional method of treating waste solvents for synthetic pharmaceutical intermediates makes the wastewater reach the dischargeable index, it will still bring huge pressure to the self-regulation ability of the ecological environment. If the waste solvents in the chemical synthesis of pharmaceutical processes can be easily The classification of organic solvents, recovery and purification of organic solvents will greatly reduce the cost of wastewater treatment, reduce environmental pressure, and recycle organic solvents to increase their added value. In view of this, in-depth research on the above problems, there is This case arises

Method used

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  • Method and equipment for recovering and purifying MTBE (methyl tert-butyl ether) waste solvent generated by synthesizing drug intermediate
  • Method and equipment for recovering and purifying MTBE (methyl tert-butyl ether) waste solvent generated by synthesizing drug intermediate
  • Method and equipment for recovering and purifying MTBE (methyl tert-butyl ether) waste solvent generated by synthesizing drug intermediate

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Embodiment 1: Take the synthetic drug intermediate waste solvent from the waste liquid tank, add it to the rectification and removal of ethylbenzene tower, rectify under normal pressure, the heating temperature is 145 ° C, the reflux ratio is controlled at 15: 1, and the top material is taken out. When the temperature at the top of the tower is 136°C, the rectified liquid is tested to be qualified and packed into tanks, filled with nitrogen for storage, and then the industrial grade ethylbenzene with a content ≥ 99.8% can be obtained. Add methyl tert-butyl ether and ethanol to the rectification tower, rectify under normal pressure, heat at 105°C, control the reflux ratio to 20:1, and extract methyl tert-butyl ether and ethanol at the top of the rectification tower with a temperature of 50 The mixture of methyl tert-butyl ether and ethanol at ~56°C, the mixture of tetrahydrofuran, tert-butanol, and tert-butyl acetate remaining in the distillation column of methyl tert-but...

Embodiment 2

[0045]Example 2: Take the waste solvent of synthetic drug intermediates from the waste liquid tank, add it to the rectification and removal of ethylbenzene tower, rectify under normal pressure, the heating temperature is 145 ° C, the reflux ratio is controlled at 10: 1, and the top material is taken out. When the temperature at the top of the tower is 136°C, the rectified liquid is tested to pass the test and filled with nitrogen for storage. The industrial grade ethylbenzene with a content of ≥99.8% can be obtained. Add methyl tert-butyl ether and ethanol to the rectification tower, rectify under normal pressure, heat at 105°C, control the reflux ratio of 15:1, and extract methyl tert-butyl ether when the tower top temperature is 50-56°C , ethanol mixture, the mixture of tetrahydrofuran, tert-butanol, and tert-butyl acetate remaining in the tower kettle, the above-mentioned components extracted from the top of the tower are added to the ethanol rectification tower, rectified u...

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Abstract

The invention discloses a method and equipment for recovering and purifying MTBE (Methyl Tert-Butyl Ether) waste solvent generated by synthesizing a drug intermediate. The method and the equipment have the beneficial effects that impurities in the waste solvent for synthesizing the drug intermediate are removed through a series of methods such as rectification, liquid-liquid extraction and the like, and an organic solvent still having recycling value is recovered. According to the recovery and purification method provided by the invention, the waste solvent for synthesizing the drug intermediate is separated through a series of low-energy-consumption processes of rectification and extraction, so that the solvent with recycling value is recycled, the pollution degree of the waste solvent to the environment in the pharmaceutical industry is reduced, and the production cost is reduced.

Description

technical field [0001] The invention relates to the technical field of solvent purification, in particular to a method and equipment for recovering and purifying waste MTBE solvents generated from synthetic drug intermediates. Background technique [0002] Chemically synthesized pharmaceutical companies will produce very serious pollution every year. The reason is that due to the long synthesis process route and too many reaction steps, the final product only accounts for 5-15% of the total raw materials, and the remaining vast majority is waste gas, waste The three wastes of liquid and waste residue exist in the form of three wastes. The discharged waste liquid has the following characteristics: most of them contain biotoxic substances that are difficult to degrade and inhibit microbial growth; they have high chroma; they contain a large amount of organic solvents, such as benzene, aliphatic compounds, ammonia nitrogen, esters, alcohols, sulfides, etc.; Contains other wast...

Claims

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Application Information

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IPC IPC(8): C07C43/04C07C41/34C07C41/42C07C41/38
CPCC07C43/046C07C41/34C07C41/42C07C41/38
Inventor 范文林黄啟虓张怡纪王洋
Owner 四川熔增环保科技有限公司
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