Application of telaprevir in the preparation of medicines for treating ischemia/reperfusion injury and cytoprotective medicines

A technology for reperfusion injury and ischemic stroke, applied in the field of biomedicine to achieve the effect of reducing serum creatine kinase activity, reducing myocardial cell and nerve cell death, and highlighting substantial characteristics

Active Publication Date: 2022-05-17
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Telaprevir is a hepatitis C virus (HCV) NS3 / 4A serine protease inhibitor, which has antiviral effects by inhibiting HCV replication, but whether it has anti-ischemia / reperfusion injury effects has not been reported

Method used

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  • Application of telaprevir in the preparation of medicines for treating ischemia/reperfusion injury and cytoprotective medicines
  • Application of telaprevir in the preparation of medicines for treating ischemia/reperfusion injury and cytoprotective medicines
  • Application of telaprevir in the preparation of medicines for treating ischemia/reperfusion injury and cytoprotective medicines

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Animal experiment: the protective effect of telaprevir on myocardial ischemia / reperfusion injury mouse model.

[0045] Experimental animals: 7-week-old male C57BL / 6J mice were fed for one week in an environment with a temperature of 25°C, a relative humidity of 60%, free access to water, and regular and quantitative amounts, and then administered according to the requirements of each group in the experiment.

[0046] Mouse myocardial ischemia / reperfusion model establishment method: 8-week-old male C57BL / 6J mice were anesthetized by intraperitoneal injection of 0.3% pentobarbital sodium (20mL / kg), orotracheal intubation, and pressure-sensitive adhesive Secure endotracheal tube. The ventilator parameters were set to a tidal volume of 3.2 mL / kg and a frequency of 110 breaths per minute. The left anterior descending artery (Left anterior descending, LAD) was ligated with an 8-0 banded suture after thoracotomy. Myocardial infarction could be judged by observing the whitenin...

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Abstract

The invention relates to the application of telaprevir in the preparation of drugs for treating ischemia / reperfusion injury and cell protection drugs. Telaprevir is used to prepare the medicine for the treatment of ischemia / reperfusion injury, especially the medicine for the treatment of cardiomyocyte and nerve cell injury, this medicine especially has good protective effect to the heart, cerebral ischemia / reperfusion (myocardium Infarction, ischemic stroke), can significantly reduce cardiac and cerebral ischemia / reperfusion injury.

Description

technical field [0001] The invention relates to the application of telaprevir in the preparation of drugs for treating or preventing ischemia / reperfusion injury and cell protection drugs, and belongs to the field of biomedicine. The present invention provides new uses and administration methods of telaprevir, including protective effects on heart and cerebral ischemia / reperfusion (especially myocardial infarction and ischemic stroke), and reducing ischemia / reperfusion injury; And cytoprotective drugs are used to protect organs, tissues or cells against cell damage and dysfunction, which expands the scope of indications of telaprevir; in addition, the present invention also covers telaprevir in the preparation of myocardial cell injury and nerve Application of cell damage protection drugs. Background technique [0002] Myocardial infarction is mainly caused by cardiac ischemia. Without timely reperfusion or the absence of collateral circulation, cardiomyocytes are irreversi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/497A61P9/10A61P43/00A61P25/00A61P27/02
CPCA61K31/497A61P9/10A61P43/00A61P25/00A61P27/02
Inventor 罗秀菊彭军张议月李明睿
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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