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Compound traditional Chinese medicine preparation for preventing and treating prototheca bovine mastitis, preparation method and application

A technology of compound traditional Chinese medicine and mastitis, applied in the field of preparation, prevention and treatment of Prototheca cow mastitis, and compound Chinese medicine preparations, can solve the threat to the quality and safety of fresh milk and public health safety, difficult to cure dairy cows, and affect the economic benefits of dairy farms To achieve the effect of controlling infection, reducing the amount of infection and improving quality

Active Publication Date: 2021-10-26
WUHAN ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The study further found that most bovine Prototheca are highly transmissible and insensitive to most antibiotics and antifungals. Once infection occurs in dairy cows, it is difficult to cure, which greatly affects the economic benefits of dairy farms and further threatens the quality and safety of raw milk and public health safety

Method used

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  • Compound traditional Chinese medicine preparation for preventing and treating prototheca bovine mastitis, preparation method and application
  • Compound traditional Chinese medicine preparation for preventing and treating prototheca bovine mastitis, preparation method and application
  • Compound traditional Chinese medicine preparation for preventing and treating prototheca bovine mastitis, preparation method and application

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preparation example Construction

[0030] The invention discloses a compound traditional Chinese medicine preparation for preventing and treating Prototheca cow mastitis, a preparation method and application thereof, as shown in the following examples. The compound traditional Chinese medicine preparation involved in the present invention includes: 40-50 parts of Phellodendron chinensis, 30-40 parts of Sophora flavescens, 10-20 parts of white root, 1-2 parts of Zanthoxylum bungeanum, and 1-2 parts of borneol. Preferably: 50 parts of Chuan Phellodendron, 38 parts of Sophora flavescens, 10 parts of Baiji, 1 part of Zanthoxylum bungeanum, and 1 part of borneol. The compound Chinese medicine preparation prepared by the application such as figure 1 shown.

[0031] Part of the Prototheca bovis involved in this application includes preservation numbers respectively CCTCC NO:M 2019978, CCTCC NO:M 2019979, CCTCC NO:M 2019980 Prototheca mesophylla, wherein the preservation number is CCTCC NO:M2019978 Prototheca mesosis ...

Embodiment 1

[0033] Take 50 parts of Sichuan Phellodendron, 38 parts of Sophora flavescens, 10 parts of Baiji, 1 part of Zanthoxylum bungeanum, 1 part of borneol (separately processed), 1kg in total, add ten times of water to fry, boil with strong fire, then simmer for 60 minutes with low heat, filter out the medicine Concentrate the medicinal solution to 1L after the residue, add ethanol according to the final concentration of 75-80% for alcohol precipitation, take the supernatant after 24 hours and carry out rotary evaporation to dryness, recover the ethanol, and obtain the compound Chinese medicine extract; dissolve the weighed borneol in a small amount of Water ethanol and Tween-80 and other cosolvents, and then added to the compound Chinese medicine extract, and finally the concentration of the compound extract is equivalent to the crude drug concentration of 1.0g / mL.

[0034] The pathogenic microorganisms Prototheca bovis strain 1 (1501#, PBHuB005, CCTCC M 2019979), Candida rugosa (d#...

Embodiment 2

[0042] Take 50 parts of Sichuan Phellodendron, 38 parts of Sophora flavescens, 10 parts of Baiji, 1 part of Zanthoxylum bungeanum, 1 part of borneol (separately processed), 1kg in total, add ten times of water to fry, boil with strong fire, then simmer for 60 minutes with low heat, filter out the medicine Concentrate the medicinal solution to 1L after the residue, add ethanol according to the final concentration of 75-80% for alcohol precipitation, take the supernatant after 24 hours and carry out rotary evaporation to dryness, recover the ethanol, and obtain the compound Chinese medicine extract; dissolve the weighed borneol in a small amount of water ethanol and Tween-80 and other co-solvents, and then added to the compound Chinese medicine extract, diluted with normal saline at 1:8 and sterilized to make the compound Chinese medicine mammary gland perfusion solution.

[0043] Three mastitis-affected cows were used for 5 consecutive days, once a day in the morning and evening...

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Abstract

The invention belongs to the technical field of disease prevention and treatment in the breeding industry, and particularly relates to a compound traditional Chinese medicine preparation for preventing and treating prototheca bovine mastitis, a preparation method and application. According to the invention, a compound traditional Chinese medicine mammary gland perfusate for preventing and treating prototheca bovine mastitis is prepared by combining traditional Chinese medicines such as cortex phellodendri chinensis, radix sophorae flavescentis and the like and performing extracting by adopting a certain process, which is beneficial to prevention and treatment of the prototheca bovine mastitis clinically. According to the invention, through mammary gland perfusion, clinical symptoms of cows suffering from prototheca bovine mastitis can be effectively relieved, and the infection amount of prototheca bovis in a milk pool is reduced, and the compound traditional Chinese medicine preparation has the advantages of clearing away heat and toxic materials, relieving swelling and pain, effectively controlling prototheca bovis infection, being appropriate in price and the like.

Description

technical field [0001] The invention belongs to the technical field of aquaculture disease prevention and control, and in particular relates to a compound traditional Chinese medicine preparation for preventing and treating Prototheca dairy cow mastitis, a preparation method and an application. Background technique [0002] Dairy cow mastitis is a common disease that endangers lactating dairy cows. It can cause a decline in milk production and fresh milk quality, cause certain economic losses, and at the same time threaten public health security to a certain extent. The etiology of dairy cow mastitis is complex and diverse, and pathogenic microorganism infection is the most difficult aspect to control among many pathogenic factors. In the past decade, dairy cow mastitis caused by Prototheca bovis has been on the rise worldwide (Ahrholdt et al 2011, Park et al 2019). The pathogenic microorganism is a chlorophyceae algae with a diameter of 7-30 μm, which was once called "medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P15/14A61P31/04A61P31/10A61K31/045
CPCA61K36/756A61K36/489A61K36/898A61K36/758A61K31/045A61K9/0041A61P15/14A61P31/04A61P31/10A61K2236/331A61K2236/333A61K2300/00
Inventor 陈洁邵志勇陈科力许顺鑫万平民金尔光陈夏冰陶丽文谭珺隽刘晓华华娟
Owner WUHAN ACADEMY OF AGRI SCI
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