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Soluble microneedle patch as well as preparation method and application thereof

A microneedle patch and soluble technology, applied in the direction of biochemical equipment and methods, microneedles, needles, etc., can solve the problems of poor long-term treatment effect, low drug delivery efficiency, and poor convenience, so as to inhibit sweat glands from secreting sweat and realize Long-term treatment, the effect of improving high efficiency

Pending Publication Date: 2021-10-29
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when applied in these therapeutic fields, there are also problems of poor convenience, low administration efficiency to the human body, and poor long-term therapeutic effect.

Method used

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  • Soluble microneedle patch as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation method of the dissolvable microneedle patch described in this embodiment comprises the following steps:

[0030] (1) Blend the functional ingredient botulinum toxin A with the microsphere solution, add it into the water phase and stir at a high speed, and the stirring rate is 450r / min; wherein the water phase adopts deionized water; the microsphere solution is polyethylene A mixed solution prepared from alcohol and a solvent, the concentration of polyvinyl alcohol in the mixed solution is 50g / L, and the solvent is dioxane; after stirring, the slow-release microspheres composed of polyvinyl alcohol and functional ingredients are in the water phase A precipitate formed. The molecular weight of the botulinum toxin A described in this example ranges from 150 to 900 kDa.

[0031] (2) The slow-release microspheres generated in step (1) are precipitated and separated by filtration or centrifugation, and after the slow-release microspheres and magnesium particl...

Embodiment 2

[0038] The preparation method of the dissolvable microneedle patch described in this embodiment comprises the following steps: (1) blending the functional ingredient botulinum toxin A with the microsphere solution, and then adding it into the water phase for high-speed stirring, the stirring rate It is 850r / min; wherein the water phase adopts ultrapure water; the microsphere solution is a mixed solution prepared from polyethylene glycol and a solvent, and the concentration of polyethylene glycol in the mixed solution is 100g / L, and the solvent It is a toluene solvent; after stirring, the slow-release microspheres composed of polyethylene glycol and functional ingredients form a precipitate in the water phase. The molecular weight of the botulinum toxin A described in this example ranges from 150 to 900 kDa.

[0039] (2) The slow-release microspheres generated in step (1) are precipitated and separated by filtration or centrifugation, and after the slow-release microspheres and...

Embodiment 3

[0046] The preparation method of the dissolvable microneedle patch described in this embodiment comprises the following steps:

[0047] (1) The functional component botulinum toxin A is blended with the microsphere solution, and then added to the water phase for high-speed stirring, and the stirring rate is 550r / min; wherein the water phase adopts deionized water; the microsphere solution is A mixed solution prepared from polylactic acid and a solvent, the concentration of polylactic acid in the mixed solution is 400g / L, and the solvent is methanol; after stirring, the slow-release microspheres composed of polylactic acid and functional ingredients are formed in the water phase precipitation. The molecular weight of the botulinum toxin A described in this example ranges from 150 to 900 kDa.

[0048] (2) The slow-release microspheres generated in step (1) are precipitated and separated by filtration or centrifugation, and after the slow-release microspheres and magnesium parti...

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Abstract

The invention provides a soluble microneedle patch as well as a preparation method and application thereof. The microneedle patch comprises a main body supporting component and sustained-release microspheres, and the main body supporting component is composed of a needle body and a base layer. The neurotoxin sustained-release microspheres are prepared from a functional component and a biocompatible high-molecular polymer material, and are coated in the needle body; the needle body is prepared from a hydrophilic high-molecular polymer and magnesium particles; and the base layer is prepared from an antibacterial high-molecular polymer material. The functional component is botulinum A. The microneedle patch disclosed by the invention effectively penetrates through a skin cuticle barrier, and as the hydrophilic high-molecular polymer material is rapidly dissolved in the skin, the sustained-release microspheres containing the functional component are implanted into a corium layer for long-term sustained release of the functional component, so that long-term treatment of diseases is realized.

Description

technical field [0001] The invention belongs to the technical field of non-invasive soluble microneedles, and in particular relates to a soluble microneedle patch and its preparation method and application. Background technique [0002] Botox is used to treat a variety of conditions, including hyperhidrosis. Hyperhidrosis is generally manifested as a symptom that refers to the excessive secretion of sweat by the sweat glands. According to statistics, 1% to 3% of the world's population suffers from hyperhidrosis. Patients with hyperhidrosis often encounter the following situations in life: wet clothes in formal social occasions; Embarrassed by the smell of sweaty underarms when in close contact. According to a 2017 sample survey in the United States, about one-third of hyperhidrosis patients stated that their sweating was almost unbearable and often interfered with ordinary daily activities. [0003] For hyperhidrosis, the current commonly used treatment methods are alumi...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/00A61K47/02A61K47/32A61K47/36A61K47/38A61K47/42A61P17/00A61P43/00A61M37/00
CPCA61K9/0021A61K38/4893A61K47/36A61K47/42A61K47/32A61K47/38A61K47/02A61P43/00A61P17/00C12Y304/24069A61M37/0015A61M2037/0046A61M2037/0053A61K47/34A61Q15/00A61K8/64A61K2800/91A61K8/19A61K2800/412A61K8/0241A61K8/735A61Q19/08
Inventor 王丽珍宁天勤姚艳樊瑜波
Owner BEIHANG UNIV
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