Soluble microneedle patch as well as preparation method and application thereof

A microneedle patch and soluble technology, applied in the direction of biochemical equipment and methods, microneedles, needles, etc., can solve the problems of poor long-term treatment effect, low drug delivery efficiency, and poor convenience, so as to inhibit sweat glands from secreting sweat and realize Long-term treatment, the effect of improving high efficiency

Pending Publication Date: 2021-10-29
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when applied in these therapeutic fields, there are also problems of poor convenie

Method used

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  • Soluble microneedle patch as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation method of the dissolvable microneedle patch described in this embodiment comprises the following steps:

[0030] (1) Blend the functional ingredient botulinum toxin A with the microsphere solution, add it into the water phase and stir at a high speed, and the stirring rate is 450r / min; wherein the water phase adopts deionized water; the microsphere solution is polyethylene A mixed solution prepared from alcohol and a solvent, the concentration of polyvinyl alcohol in the mixed solution is 50g / L, and the solvent is dioxane; after stirring, the slow-release microspheres composed of polyvinyl alcohol and functional ingredients are in the water phase A precipitate formed. The molecular weight of the botulinum toxin A described in this example ranges from 150 to 900 kDa.

[0031] (2) The slow-release microspheres generated in step (1) are precipitated and separated by filtration or centrifugation, and after the slow-release microspheres and magnesium particl...

Embodiment 2

[0038] The preparation method of the dissolvable microneedle patch described in this embodiment comprises the following steps: (1) blending the functional ingredient botulinum toxin A with the microsphere solution, and then adding it into the water phase for high-speed stirring, the stirring rate It is 850r / min; wherein the water phase adopts ultrapure water; the microsphere solution is a mixed solution prepared from polyethylene glycol and a solvent, and the concentration of polyethylene glycol in the mixed solution is 100g / L, and the solvent It is a toluene solvent; after stirring, the slow-release microspheres composed of polyethylene glycol and functional ingredients form a precipitate in the water phase. The molecular weight of the botulinum toxin A described in this example ranges from 150 to 900 kDa.

[0039] (2) The slow-release microspheres generated in step (1) are precipitated and separated by filtration or centrifugation, and after the slow-release microspheres and...

Embodiment 3

[0046] The preparation method of the dissolvable microneedle patch described in this embodiment comprises the following steps:

[0047] (1) The functional component botulinum toxin A is blended with the microsphere solution, and then added to the water phase for high-speed stirring, and the stirring rate is 550r / min; wherein the water phase adopts deionized water; the microsphere solution is A mixed solution prepared from polylactic acid and a solvent, the concentration of polylactic acid in the mixed solution is 400g / L, and the solvent is methanol; after stirring, the slow-release microspheres composed of polylactic acid and functional ingredients are formed in the water phase precipitation. The molecular weight of the botulinum toxin A described in this example ranges from 150 to 900 kDa.

[0048] (2) The slow-release microspheres generated in step (1) are precipitated and separated by filtration or centrifugation, and after the slow-release microspheres and magnesium parti...

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Abstract

The invention provides a soluble microneedle patch as well as a preparation method and application thereof. The microneedle patch comprises a main body supporting component and sustained-release microspheres, and the main body supporting component is composed of a needle body and a base layer. The neurotoxin sustained-release microspheres are prepared from a functional component and a biocompatible high-molecular polymer material, and are coated in the needle body; the needle body is prepared from a hydrophilic high-molecular polymer and magnesium particles; and the base layer is prepared from an antibacterial high-molecular polymer material. The functional component is botulinum A. The microneedle patch disclosed by the invention effectively penetrates through a skin cuticle barrier, and as the hydrophilic high-molecular polymer material is rapidly dissolved in the skin, the sustained-release microspheres containing the functional component are implanted into a corium layer for long-term sustained release of the functional component, so that long-term treatment of diseases is realized.

Description

technical field [0001] The invention belongs to the technical field of non-invasive soluble microneedles, and in particular relates to a soluble microneedle patch and its preparation method and application. Background technique [0002] Botox is used to treat a variety of conditions, including hyperhidrosis. Hyperhidrosis is generally manifested as a symptom that refers to the excessive secretion of sweat by the sweat glands. According to statistics, 1% to 3% of the world's population suffers from hyperhidrosis. Patients with hyperhidrosis often encounter the following situations in life: wet clothes in formal social occasions; Embarrassed by the smell of sweaty underarms when in close contact. According to a 2017 sample survey in the United States, about one-third of hyperhidrosis patients stated that their sweating was almost unbearable and often interfered with ordinary daily activities. [0003] For hyperhidrosis, the current commonly used treatment methods are alumi...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/00A61K47/02A61K47/32A61K47/36A61K47/38A61K47/42A61P17/00A61P43/00A61M37/00
CPCA61K9/0021A61K38/4893A61K47/36A61K47/42A61K47/32A61K47/38A61K47/02A61P43/00A61P17/00C12Y304/24069A61M37/0015A61M2037/0046A61M2037/0053
Inventor 王丽珍宁天勤姚艳樊瑜波
Owner BEIHANG UNIV
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