Polypeptide, preparation method and application thereof

A kind of use and activity-inhibiting technology, which is applied in the field of polypeptide drugs, can solve the problems of immune response and reduce the enzyme stability of polypeptide drugs, and achieve the effect of good stability
CN113563433AActive Publication Date: 2021-10-29SHANXI JINBO BIO PHARMA CO LTD
6 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANXI JINBO BIO PHARMA CO LTD
Publication Date
2021-10-29

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a polypeptide containing an amino acid sequence shown in SEQ ID NO: 1. The invention also provides a derivative of the polypeptide modified by palmitic acid or cholesterol. The polypeptide can inhibit infection of a novel 2019 coronavirus (SARS-CoV-2) and various human coronaviruses, and can also inhibit infection of a type I human immunodeficiency virus (HIV-1). The polypeptide provided by the invention has broad-spectrum antiviral activity and has higher stability than PEG modified polypeptide, and the invention aims to provide good prevention and treatment medicine reserve for SARS-CoV-2 which is still popular at present and a mutant strain of the SARS-CoV-2 as well as SARS-related viruses and human immunodeficiency viruses which are likely to break out in the future.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of polypeptide medicine, in particular to a polypeptide for broad-spectrum inhibition of coronavirus and type I human immunodeficiency virus (HIV-1). Background technique

[0002] Type I enveloped viruses such as human immunodeficiency virus (HIV) and highly pathogenic human coronaviruses (HCoV), including severe acute respiratory syndrome coronavirus (SARS-CoV), severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), among others, pose serious threats to global public health and the economy. Therefore, it is an important task to develop effective broad-spectrum anti-enveloped virus drugs to prevent the spread of existing type I enveloped viruses among humans and the possibility of new type I enveloped viruses infecting humans in the future.

[0003] In the process of type I enveloped virus infecting target cells through membrane fusion, its main feat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More