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Synthetic material powder and application thereof in hemostatic system

A technology of synthetic materials and powders, applied in applications, surgical adhesives, medical science, etc., can solve the problems of no interaction between tissues, low strength of colloids, inconvenient use, etc., and achieve the effect of good biocompatibility

Pending Publication Date: 2021-11-05
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the jelly formed by the hemostatic powder is not strong enough and is easily broken under the impact of the blood flow at the wound; the hemostatic powder does not interact with the tissue at the wound, and must be specially fixed during use, resulting in inconvenient

Method used

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  • Synthetic material powder and application thereof in hemostatic system
  • Synthetic material powder and application thereof in hemostatic system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take by weighing 140mg four-arm polyoxyethylene polyoxypropylene succinimide activated ester (as shown in formula I, wherein, m is 36, n is 21, p is 2, x is 4, R 1 is an ester bonded 2-carbon alkyl chain, R 2 succinimide activated ester), with a particle size of 2 μm, weighed 110 mg of aminochitosan, with a particle size of 2 μm, and mixed the synthetic powder and chitosan powder evenly to obtain a composite hemostatic powder.

[0037] Degradation test: Put the composite hemostatic powder after water absorption into 10 times the mass of PBS solution, then put it in a constant temperature shaker at 37±1°C, observe the gel sample in the buffer solution at a speed of 100r / min Change the situation until the time when no precipitation is seen by centrifugation, which is recorded as the degradation time of the gel in vitro.

[0038] The composite hemostatic powder prepared in this example has a water absorption capacity of 290 times the weight of the body. After absorbing wa...

Embodiment 2

[0040] Take by weighing 500mg four-arm polyacrylamide aldehyde group (as shown in formula II, wherein, m is 28, x is 4, R 1 is an ester bond, R 2 aldehyde group), the particle size is 0.2 μm, weigh 1 g of fibrin, the particle size is 0.5 μm, and mix the two powders evenly to obtain a composite hemostatic powder.

[0041] The composite hemostatic powder prepared in this example has a water absorption capacity of 300 times. After absorbing water, the composite hemostatic powder becomes jelly, and the degradation time in vitro is 3 days.

Embodiment 3

[0043] Take by weighing 100mg six-arm polyethylene glycol succinimide activated ester (as shown in formula III, wherein, m is 38, x is 6, R 1 is an amide bonded 2-carbon alkyl chain, R 2 succinimide activated ester) with a particle size of 2.5 μm, weighed 200 mg of commercially available chitosan hemostatic powder with a particle size of 2.5 μm, and mixed the two powders evenly to obtain a composite hemostatic powder.

[0044] The composite hemostatic powder prepared in this embodiment has a water absorption capacity of 200 times, which is close to the water absorption capacity (70 times) of a single commercially available chitosan hemostatic powder. After absorbing water, the composite hemostatic powder becomes jelly, and the degradation time in vitro for 4 days.

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Abstract

The invention provides synthetic material powder and application thereof in a hemostatic system. The synthetic material powder is formed by mixing synthetic molecules 1 and water absorption powder, and the synthetic molecules 1 and the water absorption powder can react with each other in the presence of blood to form gel, so that the strength of the styptic powder and the interaction capacity with tissues are enhanced. The composite styptic powder can absorb a large amount of moisture, and the degradation time can be adjusted to adapt to different bleeding positions and bleeding degrees.

Description

technical field [0001] The invention relates to a compound hemostatic powder system, in particular to a synthetic material powder and its application in a hemostatic system. Background technique [0002] For a long time, traditional methods of hemostasis such as ligation, suture, electrocoagulation, absorbable hemostatic clips and tourniquets not only increase the difficulty of surgery for medical workers, but also affect the surgical field of vision and cause hidden dangers of medical accidents. In recent years, various materials have been developed for the hemostatic seal, including hemostatic powder, hemostatic gel, hemostatic bandage, and so on. For hemostatic gel, it is difficult to apply the gel on the surface of the wound under the washing of a large blood flow, which seriously limits their application; for the hemostatic bandage, it cannot be applied to irregularly shaped wounds, and cannot seal deep wounds. Hemostasis of layered wounds. In comparison, styptic powd...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/10A61L24/04A61L24/00
CPCA61L24/0042A61L24/0094A61L2400/04
Inventor 吴德成潘正张博
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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