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Anti-inflammatory skin care product composition containing double-bacterium fermentation product and active grape seed extract for resisting urban pollution

A skin care product, grape seed technology, applied in the field of skin care products, can solve problems such as insignificant effect and unmentioned

Active Publication Date: 2021-11-09
SHANGHAI ZHONGYI DAILY CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the symbiotic fermentation products of Thermus thermophilus and Saccharomyces cerevisiae had no significant effect on inhibiting tumor necrosis factor TNF-α
Patent CN2019109574023 mainly discloses that grape seed extract has antibacterial and anti-inflammatory effects, but it does not mention which inflammatory factor expression it inhibits

Method used

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  • Anti-inflammatory skin care product composition containing double-bacterium fermentation product and active grape seed extract for resisting urban pollution
  • Anti-inflammatory skin care product composition containing double-bacterium fermentation product and active grape seed extract for resisting urban pollution
  • Anti-inflammatory skin care product composition containing double-bacterium fermentation product and active grape seed extract for resisting urban pollution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1 Add grape seed extract to the later stage of symbiotic fermentation of Thermus thermophiles and Saccharomyces cerevisiae (add 1 mg of grape seed extract to every 1 L of culture liquid)

[0053] The formula of the basic culture medium for fermentation is: 10L culture medium contains 30g peptone, 2g wort juice, 3.5g anhydrous magnesium sulfate, 1.2g potassium dihydrogen phosphate, 20g ammonium sulfate, 0.5g anhydrous ferric chloride, 2.5g sodium chloride , fill up to 10L with water. Different amounts of culture fluid are reduced or enlarged according to the ratio. The seed solution is inoculated into the culture medium at an inoculum amount of 3-10%.

[0054] All the embodiments of the present invention adopt the above-mentioned medium formula as the culture medium for strain fermentation. Of course, in actual industrial production, the proportioning can be carried out according to different requirements, and these formulas are all common formulas for cultivat...

Embodiment 2

[0069] Example 2 Grape seed extract was added to the late stage of symbiotic fermentation of Thermus thermophiles and Saccharomyces cerevisiae (add 0.1 mg of grape seed extract per 1 L of culture liquid)

[0070] Steps 1, 2, and 4 of this example are all consistent with Example 1. In step 3, the amount of grape seed extract dissolved in ethanol is changed to 1 mg. Finally, a composition of the symbiotic fermentation product of Thermus thermophiles and Saccharomyces cerevisiae and the grape seed extract was obtained, wherein the ratio of the fermentation product to the grape seed extract was 1 L: 0.1 mg.

Embodiment 3

[0071] Example 3 Grape seed extract was added to the late stage of symbiotic fermentation of Thermus thermophiles and Saccharomyces cerevisiae (10 mg of grape seed extract was added to 1 L of culture liquid)

[0072] Steps 1, 2, and 4 of this example are all consistent with Example 1. In step 3, the amount of grape seed extract dissolved in ethanol is changed to 100 mg. Finally, a composition of the symbiotic fermentation product of Thermus thermophilus and Saccharomyces cerevisiae and the grape seed extract is obtained, wherein the ratio of the fermentation product to the grape seed extract is 1L: 10mg.

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Abstract

The invention provides a skin care product which mainly comprises a compound mixture of a symbiotic fermentation product of thermus thermophilus and saccharomyces cerevisiae and a grape seed extract, preferably, the content of the symbiotic fermentation product of the thermus thermophilus and the saccharomyces cerevisiae in the compound mixture is 10%, and the content of the grape seed extract is 0.1 mu g / mL. The invention also discloses application of the compound mixture in preparation of the skin care product for resisting air dust pollution and application of the compound mixture in preparation of the skin care product for inhibiting inflammatory factors IL-8 and TNF-alpha at the same time. The skin care product can improve the self-repairing ability of cells, eliminate inflammatory response caused by urban dust, and finally prevent skin from being damaged by air dust pollution. The invention also provides a preparation method of the compound composition. The preparation method comprises the following steps: (1) adding the grape seed extract into a culture solution in a symbiotic fermentation later period of the thermus thermophilus and the saccharomyces cerevisiae, and centrifuging and degerming fermentation liquor; or (2) taking a fermentation product after the symbiotic fermentation of the thermus thermophilus and the saccharomyces cerevisiae is finished, and adding the grape seed extract.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to an anti-inflammatory skin care product composition containing bibacterium fermentation products and grape seed extract to resist urban pollution and its application. Background technique [0002] Particles in the air are very harmful to the skin. They will not only block the pores, make the skin dull and rough, but also irritate the skin, causing skin sensitivity, redness, dryness and other discomforts, and symptoms such as skin itching and skin allergies. Air pollution and UV rays are considered to be one of the main contributors to skin pollution and hair pollution. More than 80% of consumers worldwide believe that the skin absorbs airborne pollutants, with consumers in Brazil, Mexico, Pakistan and India being the most sensitive to dust, followed by Russia and China. Consumers in China, Pakistan, India, Mexico and Brazil have strong anti-pollution demands. Therefor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/9728A61K8/9789A61Q17/00A61Q19/00A61Q19/08
CPCA61K8/99A61K8/9728A61K8/9789A61Q17/00A61Q17/005A61Q19/00A61Q19/08A61K2800/85A61K2800/592
Inventor 陶侃郭莉莉
Owner SHANGHAI ZHONGYI DAILY CHEM CO LTD
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