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Hafnium-doped fluorescent carbon dots as well as preparation method and application thereof

A technology of fluorescent carbon dots and hafnium chloride, applied in chemical instruments and methods, nano-carbon, luminescent materials, etc., can solve the problems of complicated synthesis procedures, low water solubility, poor stability, etc., and achieve simple operation and high stability. , the effect of reducing residual

Active Publication Date: 2021-11-09
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, some of them have low aqueous solubility, poor stability, high toxicity, and cumbersome synthesis procedures, which become major stumbling blocks for clinical diagnosis

Method used

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  • Hafnium-doped fluorescent carbon dots as well as preparation method and application thereof
  • Hafnium-doped fluorescent carbon dots as well as preparation method and application thereof
  • Hafnium-doped fluorescent carbon dots as well as preparation method and application thereof

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preparation example Construction

[0067] The present invention also provides a preparation method of the above-mentioned hafnium-doped fluorescent carbon dots:

[0068] Step 1, dissolving citric acid, thiourea and hafnium chloride with a molar ratio of 3:9:(1-2) in water to obtain a mixed solution;

[0069] Step 2, heating the mixed solution at 180°C for 0.5-1.5h, preferably 1h, and cooling to room temperature to obtain a light brown solid;

[0070] Step 3: dissolving the light brown solid in deionized water, centrifuging, dialyzing the resulting supernatant in deionized water, and freeze-drying to obtain hafnium-doped fluorescent carbon dots.

[0071] In the above technical solution, in step 1, citric acid, thiourea and hafnium chloride are usually dissolved in water by ultrasonic, and the time is usually more than 10 minutes.

[0072] In the above technical solution, in step 3, centrifugation is sufficient until layers are separated, preferably at 10,000 rpm for more than 5 minutes.

[0073] In the above t...

Embodiment 1

[0077] Step 1. Dissolve citric acid, thiourea and hafnium chloride with a molar ratio of 3:9:1 in 5 mL of water, and disperse evenly by ultrasonication for 10 minutes to obtain a mixed solution;

[0078] Step 2. Put the mixed solution in a round-bottomed flask, heat the mixed solution at 180° C. for 1 h with an oil bath, and cool to room temperature to obtain a light brown solid;

[0079] Step 3, dissolve the light brown solid in deionized water, centrifuge at 10,000rpm for 5min, dialyze the resulting supernatant in deionized water for 24h to remove small molecules (the molecular weight cut-off of the dialysis bag is 3.5KDa), freeze-dry to obtain hafnium Doped fluorescent carbon dots, denoted as HfCDs.

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Abstract

The invention relates to hafnium-doped fluorescent carbon dots as well as a preparation method and application thereof, and belongs to the technical field of fluorescent carbon dots. The preparation method of the fluorescent carbon dots comprises the following steps of: dissolving citric acid, thiourea and hafnium chloride in water according to a molar ratio of 3: 9: (1-2), and carrying out ultrasonic treatment until the materials are uniformly dispersed to obtain a mixed solution; then heating the mixed solution at 180 DEG C for 0.5-1.5 h, and cooling to room temperature to obtain a light brown solid; and finally, dissolving the light brown solid in deionized water, centrifuging, dialyzing the obtained supernatant in deionized water, and freeze-drying to obtain the hafnium-doped fluorescent carbon dots. The hafnium-doped fluorescent carbon dots are good in stability, biocompatibility, water solubility and optical property, have remarkable computed tomography imaging performance and excellent tumor accumulation capacity, can achieve rapid and long-term imaging in a living body and can be discharged out of the body through kidney metabolism.

Description

technical field [0001] The invention belongs to the technical field of fluorescent carbon dots, and in particular relates to a hafnium-doped fluorescent carbon dot and its preparation method and application. Background technique [0002] Over the past few decades, medical imaging techniques including fluorescence imaging (FI), X-ray computed tomography (CT), photoacoustic imaging (PI) and magnetic resonance imaging (MRI) have become the most pervasive technology. Unfortunately, a single medical imaging technique cannot meet all medical diagnostic requirements. As we all know, FI has the characteristics of high sensitivity, low cost and easy operation, so it has a good effect on early non-invasive diagnosis, but its clinical application is limited because the excitation light source is difficult to penetrate deep tissues. On the other hand, although CT has inherent advantages such as high spatial resolution, it still suffers from the drawback of low sensitivity. On this ba...

Claims

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Application Information

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IPC IPC(8): C09K11/67A61K49/00A61K49/04C01B32/15
CPCC09K11/67A61K49/0019A61K49/04A61K49/0002C01B32/15Y02B20/00
Inventor 郑敏苏雅
Owner CHANGCHUN UNIV OF TECH