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Cantharidin cream and preparation method thereof

A cantharidin and cream technology, which is applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve problems such as thinning and demulsification, and achieve the effects of improving stability and simplifying the preparation process.

Pending Publication Date: 2021-11-23
HAINAN HUIYUANTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is cantharidin cream (trade name: Youslow) for external use on the market, which mainly treats condyloma acuminatum. However, after one and a half years at room temperature, the cream will break and become honeycomb and become thinner. The quality is stable. Needs further improvement in order to accommodate the 24 month shelf life of the cream

Method used

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  • Cantharidin cream and preparation method thereof
  • Cantharidin cream and preparation method thereof
  • Cantharidin cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the extraction of cantharidin

[0030] ① Pulverization: Pulverize the mylabris into a coarse powder with a pulverizer for later use.

[0031] 2. Cold soaking: add 2 times the amount of acetone (weight / volume ratio) of the weight of the cantharidin coarse powder, seal the container at room temperature, and leave it at rest for 72 hours each time, soaking three times in total;

[0032] ③ Filtration and distillation: filter the soaking liquid collected three times, collect the filter residue and send it to the dangerous goods warehouse for storage and centralized treatment. The filtrate is distilled under reduced pressure, and the temperature is controlled at 50-60°C. After recovering acetone, the residue is the mixture of cantharidin and cantharidin oil ;

[0033] ④Extraction and separation: add petroleum ether (60-90) to the mixture for extraction and separation (add petroleum ether in three times the amount of residue ), stir well and stand still for 15 m...

Embodiment 2

[0035] Embodiment 2: preparation cantharidin cream

[0036] 1. Formula

[0037] Table 1

[0038] name prescription dosage Dosage (g) Features Poloxamer P407 20％ 200 matrix Poloxamer P188 5％ 50 matrix ethanol 30％ 300 solvent Cantharidin 0.025％ 0.25 active ingredient purified water 44.975％ 449.75 solvent Total 100％ 1000 /

[0039] 2. Preparation method

[0040] (1) Weighed 200g of poloxamer P407 prescription and 50g of P188 prescription, added 449.75g of purified water of the prescription and stirred evenly, then put it in a refrigerator at 4°C and refrigerated overnight for use;

[0041] (2) Take by weighing 300g of ethanol and 0.25g of cantharidin in the prescription quantity, both are placed in the container, after dissolving and clarifying at 50°C, cool to 4°C, and stand-by;

[0042] (3) Take the mixed solution in (2) above, and slowly add the mixed solution in (1) above under stirring at 4°C (500rmp)...

Embodiment 3

[0044] Embodiment 3: paste stability comparison

[0045] 1. Comparing the product formula

[0046] Formula (based on 1000g):

[0047]

[0048] 2. Comparison of product preparation process

[0049] Dissolve cantharidin in sesame oil to make cantharidin sesame oil solution (about 120°C); dissolve stearyl alcohol and glyceryl monostearate in cantharidin sesame oil solution; filter with 200 mesh sieve, 80°C-82°C Insulation standby;

[0050] (1) Mix the soybean lecithin and purified water of the prescribed amount to make a uniform soybean lecithin dispersion, heat up to 85°C, and keep it warm at 80°C to 85°C for later use;

[0051] (2) After checking that everything is normal in the paste making machine, turn on the power according to the SOP of the YGP250 vacuum paste making machine. After sealing the equipment container, turn on the cooling water to vacuum up to the highest vacuum degree;

[0052](3) Inhale the oil phase material into the container, and start the scraper ...

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Abstract

The invention relates to the technical field of medicines, and particularly discloses cantharidin cream and a preparation method thereof. The cream comprises cantharidin, poloxamer P407, poloxamer P188, ethanol and purified water. According to the cantharidin cream, the types of auxiliary materials are adjusted, and poloxamer P407, poloxamer P188 and ethanol are used as main auxiliary materials; compared with commercially available auxiliary materials such as octadecanol, glyceryl monostearate and distearate, sesame oil and soybean phospholipid, the stability of the cream can be further improved, and the demulsification phenomenon does not occur within 24 months; and meanwhile, the preparation process is further simplified.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a cantharidin cream and a preparation method thereof. Background technique [0002] Mylabris is also known as spotted oyster, piebald hair, spotted cat, coriander, flower beetle, Zhangwa, soybean worm, etc., commonly known as Spanish fly. Mylabris is oblong, 1.5-2.5cm long, 0.5-1cm wide, with a head and mouthparts Vertically downward, with large compound eyes and 1 pair of antennae, most of which have fallen off, with 1 pair of leathery elytra on the back, black, with 3 yellow or brown horizontal striated wings and brown film-like transparent inner wings below 2 pieces, black chest and abdomen, 3 pairs of legs on the chest, special odor, cantharidin has strong nephrotoxicity, is a highly toxic substance, and can secrete a liquid called cantharidin, which is used to defend against enemies. Since the ancient Greek period, there have been records of using this liquid as an aphrodisi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/365A61K47/10A61P31/20A61K35/64C07D493/18
CPCA61K31/365A61K9/06A61K47/10A61P31/20A61K35/64C07D493/18
Inventor 方方陈容谭定渊徐朗徐扬杨尚志
Owner HAINAN HUIYUANTANG PHARMA
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