Method for monitoring toxin content distribution in in-vitro dialyzer in real time
A real-time monitoring and dialyzer technology, applied in dialysis systems, suction devices, etc., can solve problems such as only testing, not real-time monitoring of toxins, and indirect simulation of clinical analysis, etc., to achieve pertinence, quantification, and pertinence. Powerful, precise effects
Active Publication Date: 2021-11-26
WEIHAI WEIGAO BLOOD PURIFICATION PROD
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Problems solved by technology
The toxin clearance rate or decline rate of the dialyzer can indirectly reflect the quality of the dialysis effect, which has certain guiding significance for the clinic. However, the above method cannot effectively test the distribution of toxins in the flow direction of the blood chamber or dialysate chamber in real time. Promptly existing technology has following shortcoming: (1) can only test dialyzer blood chamber import and export toxin concentration, can not reflect dialyzer internal toxin distribution situation; (3) The test results can only be used for indirect simulated clinical analysis, and cannot be used for intuitive dialyzer micro-design analysis
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Embodiment 1
[0075] (1) Implantation of electrode probes:
[0076] First, punch holes on the surface of the dialyzer: take the direction of the entrance of the blood chamber as the positive direction, number ①②③④⑤ at equal intervals along the axial direction of the dialyzer, and punch holes A, B, and C at equal intervals at each numbered position along the direction perpendicular to the axial direction , D, the pore size is 3mm, the fiber membrane cannot be damaged during the punching process, see the punching position figure 2 shown; then place the potential probe: place the center position probe of the potential probe on the figure 2 At point E, after the probe is placed, seal each perforated position with a sealant to prevent fluid leakage from the dialysate chamber.
[0077] (2) Carry out in vitro clearance rate test, further output potential signal, and then through signal conversion, the final output result:
[0078] Prepare 27.58mmol / L dipotassium hydrogen phosphate toxin simula...
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The invention provides a method for monitoring toxin content distribution in an in-vitro dialyzer in real time. The method comprises the following steps: a) implanting an electrode probe into each monitoring position of the dialyzer, testing a toxin in-vitro clearance rate, and outputting a potential signal; and b) converting the potential signal into a concentration through an HPLC (High Performance Liquid Chromatography) control system, and displaying the toxin concentration value of each monitoring position in real time. Compared with the prior art, the method for monitoring the toxin content distribution in the in-vitro dialyzer in real time, provided by the invention, has the advantages that the toxin distribution condition is monitored in a mode of converting the toxin potential signal into the toxin concentration, so that the distribution condition of the toxin concentration in the dialyzer is monitored in real time; and the method has the characteristics of simplicity, rapidness, stability, high accuracy, strong pertinence, quantifiability and the like, is mainly suitable for detecting and analyzing the distribution condition of toxins in a hemodialyzer, a hemodialysis filter, a blood filter, a plasma separator and the like, and meanwhile, provides real data support for the design of a fiber membrane and a shell in the dialyzer.
Description
technical field [0001] The invention relates to the technical field of blood purification, and more specifically relates to a method for real-time monitoring the distribution of toxin content in an extracorporeal dialyzer. Background technique [0002] Chronic renal failure refers to a clinical syndrome composed of a series of symptoms and metabolic disorders caused by various kidney diseases leading to progressive and irreversible decline in renal function until the loss of function, referred to as chronic renal failure. The end stage of chronic renal failure is what is often called uremia. [0003] The best solution for patients with chronic renal failure is kidney transplantation, but kidney transplantation is facing a shortage of kidney sources, and the proportion of patients undergoing kidney transplantation in my country is very low. Therefore, for patients with chronic kidney disease, hemodialysis and peritoneal dialysis are the first choice for the treatment of rena...
Claims
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IPC IPC(8): A61M1/16
CPCA61M1/1617
Inventor 李井龙牟倡骏于亚楠曲佳伟丛慧李祥鹏王晶
Owner WEIHAI WEIGAO BLOOD PURIFICATION PROD