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Application of small molecule compound sodium phytate hydrate in preparation of medicine for resisting SARS-CoV-2

A technology of sodium alcohol hexaphosphate and small molecule compounds, applied in the field of medicine, can solve the problems of limited clinical curative effect and achieve the effect of low cytotoxicity

Active Publication Date: 2021-11-30
THE NAVAL MEDICAL UNIV OF PLA
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  • Description
  • Claims
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Problems solved by technology

Although remdesivir has received emergency use authorization from the U.S. Food and Drug Administration for the treatment of COVID-19, its clinical efficacy is relatively limited

Method used

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  • Application of small molecule compound sodium phytate hydrate in preparation of medicine for resisting SARS-CoV-2
  • Application of small molecule compound sodium phytate hydrate in preparation of medicine for resisting SARS-CoV-2
  • Application of small molecule compound sodium phytate hydrate in preparation of medicine for resisting SARS-CoV-2

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Effect test

Embodiment 1

[0021] 1. Experimental drugs, reagents and materials

[0022] 1. Compounds: Small molecule drug library (product number: L1300-Z349373) approved by the US FDA for clinical use, containing 2580 small molecule compounds, purchased from Selleck, USA, all dissolved in DMSO at a concentration of 10 μM. Remdesivir, purchased from Selleck, USA, was dissolved in DMSO at a concentration of 10 μM.

[0023] 2. African green monkey kidney cells Vero E6 and human lung adenocarcinoma cells Calu-3 were purchased from the Shanghai Cell Institute of the Chinese Academy of Sciences and preserved by the Department of Biomedical Protection, Department of Naval Medicine, Naval Medical University of the Chinese People's Liberation Army.

[0024] 3. DMEM complete cell culture medium, containing 10% fetal bovine serum, 0.03% glutamine, non-essential amino acids, ampicillin and streptomycin 100U / mL, adjust the pH to 7.4.

[0025] 4. Cell digestion solution, containing 0.25% trypsin, prepared with pho...

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Abstract

The invention discloses application of a small molecule compound sodium phytate hydrate in preparation of a medicine for resisting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the medicine for resisting the SARS-CoV-2 is a pharmaceutical composition which takes the sodium phytate hydrate as a unique active ingredient or contains the sodium phytate hydrate; and the medicine for resisting the SARS-CoV-2 is a medicine for preventing or treating SARS-CoV-2 infection. According to the invention, an SARS-CoV-2 susceptible cell line, including African green monkey kidney cells Vero E6 and human lung adenocarcinoma cells Calu-3, is utilized to detect the anti-SARS-CoV-2 activity of the sodium phytate hydrate. Experimental results show that the sodium phytate hydrate can effectively inhibit infection of the SARS-CoV-2 on the susceptible cells, is relatively low in cytotoxicity, is expected to be used as a medicine for effectively resisting SARS-CoV-2 infection, and has an application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of small molecular compound phytate sodium hydrate in the preparation of anti-SARS-CoV-2 medicine. Background technique [0002] Phytate sodium hydrate (Sodium phytate hydrate) is the precursor of other inositol phospholipids and pyrophosphate, approved by the US FDA for clinical use, it is used as a hypocalcium agent and complexing agent to remove trace amounts of heavy metal ion. There is currently no literature reporting its role in anti-SARS-CoV-2. [0003] The chemical structural formula of sodium phytate hydrate is as follows (CAS No.14306-25-3): [0004] [0005] Severe acute respiratory syndrome coronavirus 2 (Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), is a new highly infectious and highly pathogenic infectious disease pathogen, which mainly passes through the respiratory tract through droplets, close contact, etc. spr...

Claims

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Application Information

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IPC IPC(8): A61K31/6615A61P11/00A61P31/14
CPCA61K31/6615A61P11/00A61P31/14
Inventor 丁翠玲彭浩然赵兰娟赵平唐万达江亮亮唐海琳戚中田
Owner THE NAVAL MEDICAL UNIV OF PLA
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