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Composition of main ingredients for treating carbuncle, burn and acne, sustained and controlled release pharmaceutical preparation, preparation method and application thereof

A technology for burns and scald composition, applied in the field of traditional Chinese medicine preparations, can solve the problems of poor use effect and use experience, inconvenience in life and work, poor patient compliance, etc., and achieves improved medication compliance, good bioavailability, and drug release. stable effect

Active Publication Date: 2022-03-22
江苏集萃新型药物制剂技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Because above-mentioned pyretic sore carbuncle, juvenile acne and burn all are common diseases in life, and all bring great inconvenience to people's life and work
At present, there are also some external preparations such as oil and ointment for the treatment of pyretic sores, juvenile acne and burns on the market, but most of these external preparations contain antibiotic anti-inflammatory ingredients, which are irritating to the skin and have unstable drug effects. , the use effect and experience are not good, and the patient's compliance is poor

Method used

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  • Composition of main ingredients for treating carbuncle, burn and acne, sustained and controlled release pharmaceutical preparation, preparation method and application thereof
  • Composition of main ingredients for treating carbuncle, burn and acne, sustained and controlled release pharmaceutical preparation, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] (I) Ingredients

[0068] I1-main ingredient composition:

[0069] Kochia extract, 5 parts by weight;

[0070] Centella asiatica extract, 2.5 parts by weight;

[0071] Borneol, 0.2 parts by weight.

[0072] I2-Liposome:

[0073] Phospholipids: soybean lecithin, 70 parts by weight;

[0074] Sterol compounds: cholesterol, 19.3 parts by weight;

[0075] Assistant emulsifier: propylene glycol, 2.4 parts by weight; Butanol, 0.6 parts by weight;

[0076] The first solvent: diethyl ether, 1000 parts by weight.

[0077] I3-substrate:

[0078] Water-based gel compound: hydroxyethyl cellulose, 1 part by weight; carbomer, 2 parts by weight

[0079] Preservative: methylparaben, 0.1 parts by weight;

[0080] Metal ion chelating agent: disodium edetate, 0.05 parts by weight;

[0081] Osmotic pressure regulator: sodium chloride, 0.85 parts by weight;

[0082] Moisturizing agent: sodium hyaluronate, 1 part by weight; glycerin, 5 parts by weight;

[0083] The second solvent, ...

Embodiment 2

[0090] (I) Ingredients

[0091] I1-main ingredient composition:

[0092] Kochia scoparia extract, 7 parts by weight;

[0093] Centella asiatica extract, 4.5 parts by weight;

[0094] Borneol, 0.7 parts by weight.

[0095] I2-Liposome:

[0096] Phospholipids: soybean lecithin, 68.8 parts by weight;

[0097] Sterol compounds: cholesterol, 15 parts by weight;

[0098] Assistant emulsifier: propylene glycol, 3.2 parts by weight; 0.8 parts by weight of n-butanol;

[0099] The first solvent: diethyl ether, 1000 parts by weight.

[0100] I3-substrate:

[0101] Aqueous gel compound: hydroxyethyl cellulose, 0.9 parts by weight; Carbomer, 2.1 parts by weight

[0102] Preservative: methylparaben, 0.1 parts by weight;

[0103] Metal ion chelating agent: disodium edetate, 0.05 parts by weight;

[0104] Osmotic pressure regulator: sodium chloride, 0.85 parts by weight;

[0105] Moisturizing agent: sodium hyaluronate, 0.2 parts by weight; glycerin, 0.8 parts by weight;

[0106] T...

Embodiment 3

[0113] (I) Ingredients

[0114] I1-main ingredient composition:

[0115] Kochia scoparia extract, 6 parts by weight;

[0116] Centella asiatica extract, 3.5 parts by weight;

[0117] Borneol, 0.5 parts by weight.

[0118] I2-Liposome:

[0119] Phospholipids: soybean lecithin, 75 parts by weight;

[0120] Sterol compounds: cholesterol, 25 parts by weight;

[0121] Assistant emulsifier: propylene glycol, 4.3 parts by weight; 0.7 parts by weight of n-butanol;

[0122] The first solvent: diethyl ether, 1000 parts by weight.

[0123] I3-substrate:

[0124] Water-based gel compound: hydroxyethyl cellulose, 1.2 parts by weight; Carbomer, 2.80 parts by weight

[0125] Preservative: methylparaben, 0.1 parts by weight;

[0126] Metal ion chelating agent: disodium edetate, 0.05 parts by weight;

[0127] Osmotic pressure regulator: sodium chloride, 0.85 parts by weight;

[0128] Moisturizing agent: sodium hyaluronate, 0.5 parts by weight; glycerin, 3.5 parts by weight;

[0129...

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Abstract

The invention provides a main drug component composition, a slow-controlled-release pharmaceutical preparation, and a preparation method and application thereof for treating sore carbuncles, burns and scalds and acne. The main medicinal composition for treating carbuncle, burn and acne includes Kochia kohlrabi extract, Centella asiatica extract and borneol, based on the total weight of the composition, the Kochia kohlrabi extract The content of the extract is 40-75% by weight, the content of the Centella asiatica extract is 20-50% by weight, and the content of the borneol is 1-10% by weight. The main drug has the functions of expelling wind and relieving itching, detoxification and swelling, clearing heat and dispelling knots. It is non-irritating and has stable drug release. It can relieve inflammation and reduce scars caused by inflammatory reactions.

Description

technical field [0001] The present invention relates to the technical field of traditional Chinese medicine preparations, in particular to a main drug component composition for treating sores, burns and acne, a sustained and controlled release gel preparation containing the main drug component composition, and the sustained and controlled release gel preparation. Preparation method and application of gel formulation. Background technique [0002] Toxic heat sores, burns and acne are all common skin diseases in life. Toxic heat sores are also called heat toxic acne. The symptoms are mainly pustular papules, sometimes with a small amount of thick yellow pus overflowing, often with redness and pain around, and after the pustule subsides, a small sunken scar can be left on the skin surface, shaped like an orange peel. From the point of view of traditional Chinese medicine, the main reason is due to the infection of external toxins and evils, resulting in the formation of toxic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/23A61K9/127A61K47/32A61K47/38A61P17/02A61P17/10A61K31/045A61K36/185
CPCA61K36/185A61K36/23A61K31/045A61K9/06A61K9/127A61K47/38A61K47/32A61P17/02A61P17/10A61K2300/00
Inventor 全丹毅杨清林谭秀琳
Owner 江苏集萃新型药物制剂技术研究所有限公司
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