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A kind of naphthalocyanine copper and au composite material and its preparation method and application

A technology of copper naphthalocyanine and composite materials, which is applied in the direction of nanotechnology, splitting materials, wave energy or particle radiation processing materials for materials and surface science, can solve the problems of limited application and low ground state energy, and achieve improved Effects of phagocytosis, increasing effective concentration, and improving biocompatibility

Active Publication Date: 2022-06-24
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The unique macrocyclic planar conjugated system of naphthalocyanine makes the ground state energy of the molecule very low, so naphthalocyanine has good physical and chemical stability, light resistance, heat resistance, acid and alkali resistance, water immersion resistance and other advantages, but no substitution Naphthalocyanine is almost insoluble in organic solvents, which greatly limits its application

Method used

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  • A kind of naphthalocyanine copper and au composite material and its preparation method and application
  • A kind of naphthalocyanine copper and au composite material and its preparation method and application
  • A kind of naphthalocyanine copper and au composite material and its preparation method and application

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Embodiment 1

[0032] A preparation method of copper naphthalocyanine self-assembled nanomaterial, comprising the following steps:

[0033] 1) Weigh 10 mg of copper naphthalocyanine and dissolve it in 1 mL of chloroform to prepare a 10 mg / mL solution;

[0034]2) Prepare 10 mL of SDS aqueous solution with a concentration of 0.0025 mol / L;

[0035] 3) Under stirring, 1 mL of the solution in step 1) was quickly injected into the solution in step 2), the probe was sonicated for 2 min (power is 80 W), then transferred to a 65°C water bath, and quickly evaporated under stirring for 10 min , volatilize all the chloroform solution, then quickly cool to room temperature in an ice-water bath, and centrifuge at 13,000 r / min. The obtained precipitate is the self-assembled nanomaterial of copper naphthalocyanine. See the SEM pictures for details. figure 1 A.

[0036] The difference from the above scheme is: the concentration of SDS in the replacement step 2) is 0.01 mol / L ( figure 1 B), 0.0125 mol / L ( ...

Embodiment 2

[0039] A preparation method of copper naphthalocyanine and Au composite material, comprising the following steps:

[0040] 1) Dissolve 10 mg of copper naphthalocyanine in 0.5 mL of chloroform to prepare a 20 mg / mL copper naphthalocyanine / chloroform solution;

[0041] 2) Disperse the synthesized gold nanoparticles in chloroform to prepare a 40 mg / mL Au / chloroform solution;

[0042] 3) At room temperature, add 0.5 mL of the solution obtained in step 1) to 0.5 mL of the solution in step 2), and ultrasonically mix for 3-6 min to prepare a copper naphthalocyanine / gold nanoparticle / chloroform mixed solution;

[0043] 4) Prepare 10 mL of 0.015 M SDS aqueous solution;

[0044] 5) Add the solution of step 3) to the solution of step 4), sonicate the probe for 2 min (power is 80 W), volatilize in a 65°C water bath for 10 min, evaporate all the chloroform solution, and then quickly cool in an ice-water bath to Centrifuge at room temperature at 13,000 r / min, and the obtained precipitate ...

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Abstract

The present application discloses a self-assembly material of copper naphthalocyanine, a composite material of copper naphthalocyanine and Au, and its preparation method and application, including the following steps: (1) preparing a chloroform solution of copper naphthalocyanine; (2) preparing Au Chloroform (3) to prepare different concentrations of SDS aqueous solutions; (4) Add the solution of step (1) to step (3) or mix the solutions of step (1) and step (2) and add to step (3) , the probe is ultrasonically volatilized in a water bath, centrifuged, and the resulting precipitate is the copper naphthalocyanine self-assembled material and its composite material with gold nanoparticles. Due to the introduction of gold particles, this method effectively responds to the overexpressed H in the tumor microenvironment. 2 o 2 , while solving the problem of tumor hypoxia, it effectively enhances the sonodynamic therapy performance of copper naphthalocyanine. The method is simple and efficient, can be prepared in large quantities, and is finally used in photothermal therapy and sonodynamic therapy reagents. It has the advantages of good photothermal performance, less dosage, and obvious enhancement of sound sensitivity.

Description

technical field [0001] The invention belongs to the fields of material chemistry, organic supramolecular chemistry and biological nano-medicine, and particularly relates to a copper naphthalocyanine self-assembly material, a copper naphthalocyanine and Au composite material, and a preparation method and application thereof. Background technique [0002] With the development of society, the continuous deterioration of the environment, the intensification of population aging and other problems, the incidence and mortality of cancer are increasing rapidly. It is urgently important to find appropriate and efficient cancer treatment methods to prolong the lives of patients. The current clinical treatments for cancer mainly include surgery, chemotherapy and radiotherapy. However, these treatment techniques have certain limitations. How to achieve more efficient and precise treatment has become an urgent problem to be solved in the process of cancer treatment. Photothermal thera...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K49/22A61P15/00A61P35/00B82Y5/00B82Y30/00B82Y40/00
CPCA61K49/22A61K41/0052A61K41/0033A61P35/00A61P15/00B82Y5/00B82Y30/00B82Y40/00A61K2300/00
Inventor 钟永葛炎白锋鲍建帅李增银
Owner HENAN UNIVERSITY
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