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Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations

A technology of nicotinyl riboside compound and nicotinamide riboside is applied in the field of product application of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compound and nicotinyl riboside compound derivative, and can solve the problem of Issues such as unreported quantitative effects

Pending Publication Date: 2021-11-30
CHROMADEX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the effect of nicotinamide riboside (NR) on NAD has not been reported in any system + Quantitative impact of the metabolome

Method used

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  • Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations
  • Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations
  • Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0236] Nicotinamide riboside (NR, I) also occurs naturally in milk. Figure 2 shows the presence of nicotinamide riboside (NR, I) in store-bought (bovine) milk. Figure 2B and 2C is a control chromatogram showing detection of nicotinamide riboside (NR, I) after addition of nicotinamide riboside (NR, I) in known amounts to milk samples. These control chromatograms demonstrate that nicotinamide riboside (NR, I) can be added to milk and subsequently quantitatively recovered without significant degradation, or demonstrate that nicotinamide riboside (NR, I) is not compatible with commercial milk. The calculated recovery of 1% nicotinamide riboside (NR, I) was close to 100%. The experimental method used to obtain these results was as follows: Milk was diluted 1:1 with acetonitrile. Centrifugation was then performed to remove any precipitate and the supernatant analyzed using HILIC / HPLC / UV using standard methods.

[0237] Nicotinamide riboside (NR, I) also occurs naturally in huma...

example 2

[0241] A. Solutions of hydrolyzed whey protein isolate (>90% protein, 2%-7% degree of hydrolysis) were prepared at different concentrations and filtered through a 0.2 μm sterile filter. Aliquots of sterile nicotinamide riboside chloride ("NR-Cl", the salt of NR, I) in aqueous solution were spiked into the sterile whey solution, aiming for a final NR-Cl concentration of 1 mmol / liters (0.3 mg / mL). The solution containing the mixture of hydrolyzed whey and NR-Cl was filtered through a 10 kDa molecular weight cut-off centrifugal filter to remove whey protein (14-80 kDa) and any protein-bound NR-Cl. Any NR-Cl not bound to whey protein was recovered in the filtrate and quantified by HPLC. It was demonstrated that as the amount of whey in solution increased, the percentage of NR-Cl bound to whey protein increased (see Table 1).

[0242] Table 1

[0243] NR-Cl bound to hydrolyzed whey protein isolate as a function of whey to NR-Cl ratio

[0244]

[0245]

[0246] Solutions ...

example 3

[0304] Nicotinamide riboside (NR, I) is long-term unstable in water, and the bond linking the ribose sugar and the nicotinamide ring is very susceptible to hydrolysis in an aqueous liquid environment. Therefore, it is believed that by exploiting the tight chemical interaction between nicotinamide riboside (NR, I) and proteins or hydrocolloids in the powder preparation step, the ability of nicotinamide riboside (NR, I) in an aqueous environment can be demonstrated. Improved stability. It is further believed that nicotinamide riboside (NR, I) can be incorporated or encapsulated, allowing the expansion and manufacture of suitable nicotinamide riboside (NR, I) particle complexes, which show significant resistance to hydrolysis.

[0305] A. Nicotinamide riboside (NR, I) and protein binding by spray drying

[0306] Two protein sources will be chosen, dry hydrolyzed whey protein isolate and dry unhydrolyzed whey protein isolate. The starting solution will be prepared to a solids...

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Abstract

Methods for stabilizing or encapsulating at least one compound selected from the group consisting of nicotinamide riboside (NR), nicotinic acid riboside (NAR), nicotinamide mononucleotide (NMN), nicotinic acid mononucleotide (NaMN), derivatives thereof, or salts thereof, are provided. Compositions including wax prills, stabilized, or encapsulated forms of at least one compound selected from the group consisting of nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, are also provided.

Description

technical field [0001] In certain embodiments, the present invention relates to methods for directly binding and stabilizing a protein in a liquid with at least one compound selected from the group consisting of NR, NAR, NaMN and NMN, derivatives thereof, or salts thereof. compound method. In a further embodiment, the present invention relates to a composition comprising a protein directly bound to at least one compound selected from the group consisting of NR, NAR, NaMN and NMN, derivatives thereof, or salts thereof. In a further embodiment, the present invention relates to a composition comprising a protein directly bound to at least one compound selected from the group consisting of NR, NAR, NaMN and NMN, derivatives thereof, or salts thereof, the at least one compound Alone or with Thiamine (Vitamin B1), Riboflavin (Vitamin B2), Niacin (Vitamin B3), Pyridoxine (Vitamin B6), Biotin (Vitamin B7), Folate (Vitamin B9), Cobalamin (vitamin B12), retinol (vitamin A 1 ), ascorb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H19/048A61K31/7052A61K31/706A61K31/44C07H19/04
CPCA61K31/706A61K9/0056A61K47/44A61K9/1617A61K9/148A61K9/5015A23L33/115A23L33/13A23L33/15A23L33/17A23L33/40C07H19/048A61K45/06A61K9/14
Inventor 阿伦·埃里克森阿曼达·斯托约翰菲利普·雷德帕思马修·罗伯茨
Owner CHROMADEX
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