Method for accurately measuring content of nonylphenol in cosmetics

Abstract

The invention discloses a method for accurately measuring the content of nonylphenol in cosmetics, and relates to the technical field of cosmetic component detection, and the method is characterized by comprising the following steps: adding a quantitative reference substance with known concentration into a cosmetic sample; calculating to obtain a relative response factor of the reference substance and the nonylphenol; calculating to obtain a correction coefficient; correcting the relative response factor according to the correction coefficient to obtain a final response factor; and according to the final response factor and the known concentration and quantitative volume of the reference substance, obtaining the measured content of nonylphenol in the cosmetic sample through calculation. According to the method disclosed by the invention, the influence of factors such as a temperature environment and a system after the reference substance is added in a determination process of a gas chromatography-mass spectrometry instrument is considered, and the content of the nonylphenol is determined by adopting the gas chromatography-mass spectrometry instrument after the reference substance is added into the cosmetic sample, a nonylphenol measurement result is corrected according to the error between the measurement result of the reference substance and the real situation, and the accuracy of nonylphenol content measurement in the cosmetic sample is effectively improved.

Description

technical field [0001] The invention relates to the technical field of detection of cosmetic components, more specifically, it relates to a method for accurately measuring nonylphenol content in cosmetics. Background technique [0002] Nonylphenol is an important fine chemical raw material and intermediate. Its appearance is colorless or light yellow liquid at room temperature, with a slight phenol smell. It is insoluble in water, slightly soluble in petroleum ether, soluble in acetone and carbon tetrachloride , ethanol and chloroform. Mainly used in the production of surfactants, but also in antioxidants, textile printing and dyeing auxiliaries, lubricating oil additives, pesticide emulsifiers, resin modifiers, resin and rubber stabilizers and other fields. Nonylphenol has strong lipophilicity and is not easy to decompose in the environment. Because of its chemical structure similar to animal and human estrogen, once it enters the animal and human body, it will interfere w...

AI Technical Summary

Problems solved by technology

However, the two nonylphenol determination methods described in the above prior art are affected by factors such as damage to the treatment solution and incomplete extraction during the determination process, resulting in large errors in the determination results of nonylphenol

In addition, the prior art also discloses a method for the determination of nonylphenol in soil. The method is determined by adding a substitute and using gas chromatography-mass spectrometry. The measurement results were corrected to effectively reduce the measurement error of nonylphenol. However, due to the large difference between the composition of the soil and the composition of daily chemical products such as cosmetics, it is impossible to use gas chromatography for nonylphenol in soil. -The mass spectrometry detection method is directly applied to the determination of nonylphenol in cosmetics and other daily chemical products, and is affected by the addition of the substitute itself, as well as the physical properties of the substitute and nonylphenol, and its calibration accuracy needs to be further improved

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