Degradable drug sustained-release material and preparation method thereof
A slow-release material and drug technology, applied in the fields of botanical equipment and methods, chemicals for biological control, biocides, etc., can solve the problems of limited application, lack of degradation performance, secondary pollution, etc. the effect of demand
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Embodiment 1
[0047] A degradable drug sustained-release material, which is prepared by the following method:
[0048] 1) Preparation of amphiphilic chitosan:
[0049] 1-1) Add 3g of chitosan, 1.5g of NaOH, and 15ml of isopropanol into a 150ml three-necked flask, stir, heat to 55°C, and react for 2 hours to alkalize the chitosan;
[0050] 1-2. Add 1-chloropropane dropwise to the reaction product obtained in step 1-1), and react under heating conditions for 4 hours;
[0051] 1-3. After the reaction is over, the chitosan changes from white powder to yellow powder, and part of it adheres to the bottle wall. Wash out the product 1 obtained in step 1-2) with 40ml of ethanol, and then pour it into the product 1 Adding dilute hydrochloric acid with a mass fraction of 5% to the solution neutralizes the pH value to neutral;
[0052] 1-4. Add 20ml of acetone to the product 1 obtained in step 1-3), precipitate product 2, let stand, filter, wash the precipitate with acetone, remove excess impurities,...
Embodiment 2
[0064] 1. A degradable drug sustained-release material, which is prepared by the following method:
[0065] 1) Preparation of amphiphilic chitosan:
[0066] 1-1) Add 3g of chitosan, 1.5g of NaOH, and 15ml of isopropanol into a 150ml three-necked flask, stir, heat to 55°C, and react for 2 hours to alkalize the chitosan;
[0067] 1-2. Add 1-chloropropane dropwise to the reaction product obtained in step 1-1), and react under heating conditions for 4 hours;
[0068] 1-3. After the reaction is over, the chitosan changes from white powder to yellow powder, and part of it adheres to the bottle wall. Wash out the product 1 obtained in step 1-2) with 40ml of ethanol, and then pour it into the product 1 Adding dilute hydrochloric acid with a mass fraction of 5% to the solution neutralizes the pH value to neutral;
[0069] 1-4. Add 20ml of acetone to the product 1 obtained in step 1-3), precipitate product 2, let stand, filter, wash the precipitate with acetone, remove excess impuriti...
Embodiment 3
[0081] 1. A degradable drug sustained-release material, which is prepared by the following method:
[0082] 1) Preparation of amphiphilic chitosan:
[0083] 1-1) Add 3g of chitosan, 1.5g of NaOH, and 15ml of isopropanol into a 150ml three-necked flask, stir, heat to 55°C, and react for 2 hours to alkalize the chitosan;
[0084] 1-2. Add 1-chloropropane dropwise to the reaction product obtained in step 1-1), and react under heating conditions for 4 hours;
[0085] 1-3. After the reaction is over, the chitosan changes from white powder to yellow powder, and part of it adheres to the bottle wall. Wash out the product 1 obtained in step 1-2) with 40ml of ethanol, and then pour it into the product 1 Adding dilute hydrochloric acid with a mass fraction of 5% to the solution neutralizes the pH value to neutral;
[0086] 1-4. Add 20ml of acetone to the product 1 obtained in step 1-3), precipitate product 2, let stand, filter, wash the precipitate with acetone, remove excess impuriti...
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