Curcumin-loaded ovalbumin-sodium alginate nanogel and preparation method thereof
A technology for loading curcumin and ovalbumin, which is applied in the field of preparation of curcumin-encapsulated ovalbumin-sodium alginate nanogels, can solve the problems that ovalbumin-sodium alginate nanogel curcumin has not yet been discovered, and achieve biological Increased yield, strong anti-digestion ability, and improved conversion rate
Active Publication Date: 2022-02-08
JIANGSU ACAD OF AGRI SCI
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Problems solved by technology
[0004] After checking the literature and patents, no report has been found on the use of ovalbumin-sodium alginate nanogel for carrying curcumin
Method used
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Embodiment 1
[0024] 1. Preparation of the aqueous solution of sodium alginate with ovalbumin
[0025] Weigh accurately 2.0g 1.0g powdered egg albumin or sodium alginate powder was placed 250mL Erlenmeyer flask, 100mL of distilled water was added, with magnetic stirring 440rpm conditions 4h, stand in a refrigerator overnight under 4 ℃, to give a concentration of 2.0 % solution of egg albumin and 1.0% sodium alginate solution.
[0026] Preparation of curcumin complex solution - 2. ovalbumin
[0027] Weigh accurately 10mg curcumin powder (purity higher than 65%) was dissolved in 2.5mL of ethanol to obtain a concentration of 4.0mg / mL ethanol solution of curcumin; imbibe above curcumin solution 1mL, 10mL was added dropwise a solution of ovalbumin in, IH magnetic stirring 440 rpm; the composite was placed in a centrifuge at 1000g 5min conditions, insolubles were removed, and the composite was sealed in a dialysis bag 1000Da, dialyzed in distilled water 4h remove the ethanol.
[0028] 3. Load curcu...
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Abstract
The invention relates to the field of food nanotechnology, and discloses a curcumin-loaded ovalbumin-sodium alginate nanogel and a preparation method thereof. The ovalbumin-sodium alginate nanogel of the loading curcumin is prepared by the following method: ovalbumin solution (2.0%, w / w) is mixed with curcumin ethanol solution (4mg / mL), makes curcumin quality reach egg white 1.0‑5.0% of the protein content, centrifuged to remove insoluble matter and dialyzed to remove ethanol; according to the volume ratio of 1:1, the ovalbumin‑curcumin complex solution was mixed with sodium alginate solution (1.0%, w / w), and washed with 1M acetic acid The mixed solution was acidified to pH 4.0; the mixed solution was heated at 70° C. for 15 min, and then cooled to room temperature in an ice bath for later use. The nano gel has small size, high potential and uniform particle size distribution. During the simulated digestion process, ovalbumin-sodium alginate nanogel can effectively protect curcumin from degradation and realize its slow-release control, thereby improving the conversion rate and bioavailability of curcumin.
Description
Technical field [0001] The present invention belongs to the technical field of food nanometer, it applied in particular to a curcumin encapsulated ovalbumin - alginate gel process nanometers. Background technique [0002] Curcumin is a plant of the genus diketones such as turmeric rhizomes, turmeric extract and the like obtained from turmeric, physiologically active anti-tumor, anti-inflammatory, anti-oxidation. US National Cancer Institute has listed it as the third-generation cancer chemopreventive agents. However, water-soluble curcumin is very low (only 11ng / mL under the conditions of the pH 7.4), crystallized readily in the digestive tract, can not be sufficiently solubilized in the intestinal absorption of bile salt micelles; on the other hand, curcumin poor stability, and complex curcumin orally ingested enzymes, likely to occur at body pH, temperature condition under the action of the intestinal flora of alkaline hydrolysis, conjugation and sulfated, dextrose glucuronid...
Claims
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IPC IPC(8): A61K47/69A61K31/12A61K47/64A61P35/00A61P29/00A61P39/06
CPCA61K47/643A61K47/6903A61P29/00A61P35/00A61P39/06A61K31/12
Inventor 冯进李春阳邢永娜
Owner JIANGSU ACAD OF AGRI SCI