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NANO particles comprising copolymeric or homopolymeric compounds which comprise cyanoacrylate sub-units

A technology of cyanoacrylate and nanoparticles, which is applied in the field of nanoparticles and can solve the problem of no toxicity of PACA nanoparticles

Pending Publication Date: 2022-01-18
新泰福托特股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sulheim et al. 2017 concluded that understanding the toxicity of nanoparticles is challenging and that no single property can explain the observed toxic effects of PACA nanoparticles

Method used

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  • NANO particles comprising copolymeric or homopolymeric compounds which comprise cyanoacrylate sub-units
  • NANO particles comprising copolymeric or homopolymeric compounds which comprise cyanoacrylate sub-units
  • NANO particles comprising copolymeric or homopolymeric compounds which comprise cyanoacrylate sub-units

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0247] Materials and methods

[0248] Quantification of alcohol toxicity

[0249] Cell Lines: Cell lines were used to determine alcohol cytotoxicity Hep G2 (human liver cancer cell line), LLC-PK1 (pig kidney cell line) and IMR-90 (human lung fibroblast cell line). All media were passed through 10% (w / v) fetal bovine serum albumin (Sigma) and 100 units / ml penicillin / streptomycin ( Sigma) for reinforcement. All cell lines were obtained from ATCC and routinely tested for mycoplasma. Grow cells in 24-well plates or 96-well plates with serial dilutions of alcohol at 37 °C and 5% CO 2 Incubate in an atmosphere for 24 hours. Toxicity was assessed by the commonly used MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell viability assay.

[0250] MTT cell viability assay. Cells were incubated with different nanoparticles / substances for 24 hours. Cell culture medium was then aspirated and replaced with 100 μl of medium at a final concentration of 250 μg MTT / ...

Embodiment approach 1

[0278] Embodiment 1. A novel nanoparticle comprising a copolymeric or homopolymeric compound according to formula 1;

[0279]

[0280] wherein the compound comprises a polymerizable cyanoacrylate monomer according to formula 2:

[0281]

[0282] R in at least one of the polymerizable cyanoacrylate monomers 1 independently selected from 2-ethylhexyl, 2-phenylethyl, neopentyl, 1-pentyl, 2-pentyl, 3-pentyl, 3,3-dimethyl-1-butyl, 3 - the group consisting of methylbutyl, 1-heptyl, 2-heptyl and 3-heptyl.

Embodiment approach 2

[0283] Embodiment 2. The nanoparticle according to embodiment 1, wherein R in the at least one polymerizable cyanoacrylate monomer 1 independently selected from 2-ethylhexyl, 2-phenylethyl, neopentyl, 1-pentyl, 2-pentyl, 3-pentyl, 3,3-dimethyl-1-butyl, 1 - the group consisting of heptyl, 2-heptyl and 3-heptyl.

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Abstract

The invention relates to a nano particle comprising copolymeric or homopolymeric compounds which comprise cyanoacrylate sub-units according to formula 2A, wherein each R1 is independently selected from the group consisting of 2-ethyl hexyl, 2-phenyl ethyl, neo-pentyl, 1-pentyl, 2-pentyl, 3-pentyl, 3,3-dimethyl-1-butyl, 3-methyl butyl, 1-heptyl, 2-heptyl, and 3-heptyl; and the nano particle further comprises an active agent. The invention also provides compositions comprising the nano particles, and the nano particles for use in therapy or diagnosis, such as in the treatment of cancer or an infection, or for use in diagnostic imaging.

Description

technical field [0001] The present invention relates to nanoparticles comprising copolymeric or homopolymeric compounds formed from cyanoacrylate monomers. Active agents are encapsulated in nanoparticles. The present invention also relates to compositions comprising said nanoparticles and their use in medicine (such as drug delivery and molecular imaging), agriculture, aquaculture, nutraceuticals, food / feed applications, cosmetics, self-healing, household applications and body care Applications. Background technique [0002] The application of nanoencapsulation offers exciting possibilities for many markets where volatile, sensitive or harmful materials / compounds need to be protected / concealed / masked / isolated and delivered / co-delivered to desired targets. This is especially important in the rapidly developing field of nanomedicine. [0003] Two areas in which the application of nanoparticles has begun to show particular value are drug delivery and molecular imaging. Howe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/51C08F222/32
CPCA61K9/5138C08F222/324A61K49/0028A61K49/0093A61K31/4439A61K31/337A61K31/351A61K31/555A61K31/18A61P35/00A61P31/00C08F222/326
Inventor R·施密德P·莫尔斯沃思Y·马尔奇
Owner 新泰福托特股份有限公司