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COF film material and preparation method and application thereof

A membrane material and membrane layer technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. The effect of compatibility, good chemical stability, good biocompatibility and chemical stability

Active Publication Date: 2022-01-25
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to realize the constant release of drugs, various traditional porous materials have been studied, such as porous zeolite materials, but the rigidity of their framework greatly limits its practical application, and the porosity of traditional flexible polymer film materials is too low

Method used

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  • COF film material and preparation method and application thereof
  • COF film material and preparation method and application thereof
  • COF film material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] In this example, a COF membrane is prepared, and the preparation method is as follows:

[0061] (1) Dissolve 10 mg of 2,4,6-triformylphloroglucinol in 30 mL of dichloromethane to form solution a;

[0062] (2) Dissolve 10 mg of p-phenylenediamine hydrochloride in 30 mL of water three times to form solution b;

[0063] (3) Add the aqueous phase solution b obtained in step (2) to the upper layer of the oil phase solution a, and react at 25° C. for 7 hours, and the two monomers are polymerized at the interface of the two phases to form a COF membrane.

[0064] The prepared COF membrane was observed with a scanning electron microscope, as shown in figure 1 As shown, it can be seen from the figure that the synthesized COF membrane has a large area, is complete and has no defects. The microscopic molecular structure of the COF membrane is as follows: figure 2 shown.

Embodiment 2

[0066] This example prepares a COF membrane material with a sandwich structure, and its preparation method is as follows:

[0067] (1) Spin-coat a solution of polycaprolactone (number-average molecular weight 80,000) with a mass concentration of 500 mg / mL on a silica substrate, spin-coat at a speed of 1500 rpm for 30 seconds, and then spin-coat at a speed of 2000 rpm for 60 seconds to form the first A polycaprolactone layer, dried at 25°C;

[0068] (2) Contact the silicon dioxide base sheet obtained in step (1) with the COF film layer prepared in Example 1, so that the COF film layer is covered on the first polycaprolactone layer, and dried at 25° C.;

[0069] (3) Spin-coat the polycaprolactone solution with a mass concentration of 500mg / mL on the surface of the COF film layer of the product in step (2), spin-coat at a speed of 1500rpm for 30s, and then spin-coat at a speed of 2000rpm for 60s to form a second Polycaprolactone layer, dried at 25°C;

[0070] (4) Etching the si...

Embodiment 3

[0072] In this example, the COF membrane material prepared in Example 2 is tested for the release performance of the drug molecule oxytocin, and the operation method is as follows:

[0073] Oxytocin was placed in the drug release test device, the COF membrane material was placed on top and sealed, and the entire device was placed in phosphate buffer at 37°C to simulate physiological conditions, and the oxytocin (ELISA) kit was used to determine the phosphate buffer The content of oxytocin released in the medium, and calculate the cumulative release amount; at the same time, use the product prepared by the following method as a comparison, and use the same test method to calculate the cumulative release amount, such as image 3 shown by image 3 It can be seen that simple polycaprolactone film cannot obtain zero-order sustained-release behavior of oxytocin, but the COF film material involved in the present invention can obtain zero-order sustained-release behavior of oxytocin a...

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Abstract

The invention relates to a COF film material. The COF film material comprises a first polycaprolactone layer, a COF film layer and a second polycaprolactone layer which are sequentially stacked; the COF film layer is prepared from 2, 4, 6-trimethylacylphloroglucinol and p-phenylenediamine hydrochloride. The COF film material is a material with a sandwich structure, the middle COF film layer is a porous polymer film layer which is formed by connecting organic small molecules through covalent bonds and has permanent uniform ordered micropores and a regular crystal structure, and due to the fact that the size of diffusion molecules is equivalent to the pore diameter of the film, constant release of drug molecules is achieved; a porous network is constructed by covalent bonds, and good chemical stability is given to the materials; the construction elements are light non-metallic elements, and therefore high biocompatibility is achieved. The COF film layer is better protected by the upper polycaprolactone layer and the lower polycaprolactone layer, and the COF film layer is not likely to be damaged.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and relates to a COF membrane material and its preparation method and application, in particular to a COF membrane material with good biocompatibility, high stability and controllable thickness, its preparation method and application. Background technique [0002] COF is a porous polymer with permanent micropores and regular crystal structure formed by small organic molecules linked by covalent bonds. Due to its high specific surface area, high porosity, controllable pore size, structural diversity, and good chemical stability, this material is widely used in the fields of energy storage, adsorption, separation, catalysis, optoelectronics, and sensing. Show great application prospects. [0003] CN111087615A discloses a COF membrane, which uses the polymerization reaction between hexaaminotriptycene and pyrenetetraketone compounds to prepare COF membrane materials, and obtains a kind of A ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/34A61K38/095C08G73/00
CPCA61K9/0087A61K47/34A61K38/095C08G73/00
Inventor 唐智勇李连山韩晶侯郡郡邱雪英
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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