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PLGA nano particle for encapsulating DL-menthol and diclofenac as well as preparation method and application of PLGA nano particle

A diclofenac and nanoparticle technology, applied in the field of nanomaterials, can solve problems such as postoperative inflammation, tumor tissue residue, etc., and achieve the effects of reducing inflammatory response, good stability, and reducing adverse inflammatory response

Active Publication Date: 2022-01-28
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problems of tumor tissue residue and postoperative inflammation caused by energy attenuation in the hyperthermia process of HIFU surgery, the present invention constructed a PLGA nanoparticle encapsulating DL-menthol and diclofenac

Method used

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  • PLGA nano particle for encapsulating DL-menthol and diclofenac as well as preparation method and application of PLGA nano particle
  • PLGA nano particle for encapsulating DL-menthol and diclofenac as well as preparation method and application of PLGA nano particle
  • PLGA nano particle for encapsulating DL-menthol and diclofenac as well as preparation method and application of PLGA nano particle

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Embodiment 1

[0033] The present embodiment prepares the PLGA nanoparticle of encapsulating DL-menthol and diclofenac as follows:

[0034] (1) Dissolve 100mg PLGA powder and 50mg DL-menthol in 4mL CH 2 Cl 2 1 mL of DMSO solution containing 20 mg of diclofenac was added, and the resulting mixture was added to 20 mL of PVA solution with a mass concentration of 2%, and an emulsion was formed after probe ultrasonication (50% output power) for 5 min.

[0035] (2) The resulting emulsion was stirred at room temperature for 4 h. After the stirring, centrifuge at 9000rpm for 10min and wash with water 5 times to obtain PLGA nanoparticles encapsulating DL-menthol and diclofenac, which are denoted as diclofenac / DL-menthol@PLGA NPs (DC / DLM@PLGA NPs).

[0036] figure 2 It is the transmission electron microscope image of DC / DLM@PLGA NPs obtained in this example. It can be seen from the figure that the diameter of the nanoparticles is 340-460 nm.

[0037] image 3 It is the thermal phase transition ...

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Abstract

The invention discloses a PLGA nano particle for encapsulating DL-menthol and diclofenac as well as a preparation method and application of the PLGA nano particle. The PLGA nano particle is used as a carrier, and the DL-menthol and the diclofenac are simultaneously encapsulated in the PLGA nano particle. The nano particle has the functions of enhancing the HIFU heat effect, reducing the heat resistance of tumor cells and relieving the inflammatory response after the HIFU operation, can effectively inhibit glycolysis of tumors, and can be used for preparing an HIFU sensitizer for treating the tumors.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and specifically relates to a PLGA nanoparticle encapsulating DL-menthol and diclofenac for enhancing the thermal effect of HIFU and alleviating postoperative inflammation to treat tumors, and a preparation method and application thereof. Background technique [0002] Cancer is one of the major diseases that seriously threaten human health. Its mainstream treatment methods include surgery, radiation therapy, and chemotherapy. However, due to the extremely complex interrelationship among tumor, host, and treatment methods, cancer is prone to relapse, metastasis, or new symptoms after treatment by these three methods, which reduces the final treatment effect of cancer. Therefore, the development of new cancer treatment technologies can make up for the deficiencies of current clinical treatment technologies, and is expected to improve the survival period and quality of life of cancer patients....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/34A61K31/196A61K31/045A61P35/00A61P29/00B82Y5/00B82Y40/00
CPCA61K9/5153A61K9/5192A61K31/196A61K31/045A61P35/00A61P29/00B82Y5/00B82Y40/00A61K2300/00Y02A50/30
Inventor 查正宝武海涛
Owner HEFEI UNIV OF TECH