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Disinfection medicine for root canal and preparation method thereof

A root canal and drug technology, applied in the field of root canal disinfection drugs and its preparation, can solve problems such as unclear influence, and achieve the effect of improving the inhibitory effect

Active Publication Date: 2022-01-28
BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of chelating agents such as EDTA on the antibacterial effect of chitosan is not yet clear

Method used

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  • Disinfection medicine for root canal and preparation method thereof
  • Disinfection medicine for root canal and preparation method thereof
  • Disinfection medicine for root canal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The effect of embodiment 1 single chelating agent on three kinds of chitosan antibacterial

[0036] A root canal disinfection medicine, including chitosan, chelating agent, Tween 80 and neutralizing solution. The neutralizing solution is glacial acetic acid and 0.5M aqueous sodium hydroxide solution, and the volume ratio of the two is 3:5.

[0037] The contents of chitosan, chelating agent and Tween 80 are shown in the table below:

[0038] Table 1 Antiseptic drug formula in the root canal

[0039]

[0040]

[0041] The preparation method of antiseptic medicine in root canal comprises the following steps:

[0042] (1) Get chitosan and join in glacial acetic acid, stir and dissolve, then add sodium hydroxide aqueous solution, stir;

[0043] (2) Add the chelating agent and Tween 80 in sequence, and stir evenly to obtain the disinfectant in the root canal.

Embodiment 2

[0044] The effect of embodiment 2 compound chelating agent on three kinds of chitosan antibacterial

[0045] A root canal disinfection medicine, including chitosan, chelating agent, Tween 80 and neutralizing solution. The neutralizing solution is glacial acetic acid and 0.5M aqueous sodium hydroxide solution, and the volume ratio of the two is 3:5.

[0046] The contents of chitosan, chelating agent and Tween 80 are shown in the table below:

[0047] Table 3 Antiseptic drug formula in the root canal

[0048]

[0049] The preparation method of the antiseptic drug in the root canal is the same as in Example 1. Wherein the chelating agent is added sequentially in the order of ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid and ethylenediaminetetramethylenephosphonic acid, and then stirred evenly.

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Abstract

The invention discloses a disinfection medicine for a root canal and a preparation method thereof, and belongs to the technical field of oral medicines. The disinfection medicine is in a liquid state and comprises chitosan, a chelating agent and a solvent. According to the disinfection medicine for the root canal, the chitosan is used as a main active component, the chelating agent and the surfactant Tween 80 are used as auxiliary agents, and the disinfection medicine has a relatively strong inhibition effect on main related bacteria, such as porphyromonas pulp, porphyromonas gingivalis and prevotella intermedius, for root canal infection.

Description

technical field [0001] The invention belongs to the technical field of oral medicine, and in particular relates to a root canal disinfection medicine and a preparation method thereof. Background technique [0002] Chitin is the second most abundant natural polysaccharide on earth after cellulose, and is widely found in marine arthropods, such as shells of crustaceans such as shrimps and crabs. Chitosan is the product of deacetylation of chitin. Chitosan has many unique biological activities such as antibacterial and antitumor. [0003] Ke Song et al 【 1] The research progress of chitosan's antibacterial and fungal inhibitory effects was reviewed, and it was considered that there are many and complex factors affecting the antibacterial performance of chitosan. Metal ions, bacterial strains, crystal forms, etc., and various factors interact with each other, making it difficult to evaluate the factors affecting the antibacterial activity of chitosan. In a previous study by ...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K33/30A61K31/722A61K31/198A61P1/02A61P31/02A61P31/04
CPCA61K33/38A61K33/30A61K31/722A61K31/198A61P1/02A61P31/02A61P31/04A61K2300/00
Inventor 刘琨侯本祥
Owner BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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