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L-carnitine blue copper peptide ionic liquid, and preparation method and application thereof

An ionic liquid, blue copper peptide technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve problems such as difficulty in exerting efficacy, poor hydrophilicity, denaturation and inactivation, etc., to reduce wrinkles and reduce firmness. Skin, the effect of improving skin permeability and stability

Active Publication Date: 2022-02-15
GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although blue copper peptide has many and outstanding functions, it is difficult to be directly absorbed by the skin due to its poor hydrophilicity, and it is also easy to add to cosmetics Denatured and inactivated by temperature, pH and other factors, so that it is difficult to exert its unique effects

Method used

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  • L-carnitine blue copper peptide ionic liquid, and preparation method and application thereof
  • L-carnitine blue copper peptide ionic liquid, and preparation method and application thereof
  • L-carnitine blue copper peptide ionic liquid, and preparation method and application thereof

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Effect test

Embodiment 1

[0048] This embodiment provides an L-carnitine-based blue copper peptide ionic liquid, the preparation method of which is as follows:

[0049] Under nitrogen atmosphere, add 0.01mol L-carnitine into the reactor, then add 0.01mol tartaric acid dropwise into the reactor with L-carnitine, stir to mix evenly, heat to 50°C, ionization modification reaction 16 hours; after the reaction is completed, the solution is concentrated in a rotary evaporator to 1 / 5 of the reaction solution, and the pure L-carnitine tartrate ionic liquid can be obtained after dialysis. Its H NMR spectrum and C NMR spectrum are as follows figure 1 , figure 2 shown.

[0050] Under a nitrogen atmosphere, slowly add 0.01 mg of azurite peptide into the L-carnitine tartrate ionic liquid, stir at 25°C for 2.5 h under magnetic stirring, dialyze for 1 h, and dry for 2.5 h to obtain L-carnitine Copper-based peptide ionic liquid.

Embodiment 2

[0052] This embodiment provides an L-carnitine-based blue copper peptide ionic liquid, the preparation method of which is as follows:

[0053] Under a nitrogen atmosphere, add 0.01mol L-carnitine into the reactor, then add 0.02mol tartaric acid dropwise into the reactor with L-carnitine, stir to mix evenly, heat to 20°C, ionization modification reaction 4h; After the reaction is completed, the solution is concentrated in a rotary evaporator to 1 / 8 of the reaction solution, and the pure L-carnitine tartrate ionic liquid can be obtained after dialysis.

[0054] Under a nitrogen atmosphere, slowly add 0.01 mg of azurite peptide into the L-carnitine tartrate ionic liquid, stir at 25°C for 1.0 h under magnetic stirring, dialyze for 1 h, and dry for 3.5 h to obtain L-carnitine Copper-based peptide ionic liquid.

Embodiment 3

[0056] This embodiment provides an L-carnitine-based blue copper peptide ionic liquid, the preparation method of which is as follows:

[0057] Under nitrogen atmosphere, add 0.01mol L-carnitine into the reactor, then add 0.04mol tartaric acid dropwise into the reactor with L-carnitine and stir to mix evenly, heat to 80°C, ionization modification reaction 24 hours; after the reaction is completed, the solution is concentrated in a rotary evaporator to 1 / 3 of the reaction solution, and the pure L-carnitine tartrate ionic liquid can be obtained after dialysis.

[0058] Under a nitrogen atmosphere, slowly add 0.01 mg of azurite peptide into the L-carnitine tartrate ionic liquid, stir at 25°C for 4.5 hours under magnetic stirring, dialyze for 1 hour, and dry for 4.5 hours to obtain L-carnitine Copper-based peptide ionic liquid.

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Abstract

The invention relates to L-carnitine blue copper peptide ionic liquid, and a preparation method and application thereof. The L-carnitine blue copper peptide ionic liquid comprises L-carnitine tartaric acid ionic liquid and blue copper peptide wrapped in the L-carnitine tartaric acid ionic liquid. According to the L-carnitine blue copper peptide ionic liquid, the specific L-carnitine tartaric acid ionic liquid is selected as a carrier, blue copper peptide with poor stability and transdermal absorbability is wrapped in the carrier, the original effect of the blue copper peptide can be guaranteed, the skin permeability and stability of the blue copper peptide can be improved, and the bioavailability of the blue copper peptide is greatly improved. In addition, tartaric acid molecules in the L-carnitine tartaric acid ionic liquid carrier and blue copper peptide have remarkable synergistic effects in the efficacy aspects of resisting oxidation, reducing wrinkles, tightening skin, stimulating generation of collagen and elastin and the like.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and relates to an L-carnitine-based blue copper peptide ionic liquid and its preparation method and application, in particular to an L-carnitine-based blue copper peptide ionic liquid and its preparation method and in the preparation of cosmetics Applications. Background technique [0002] The Chinese alias of blue copper peptide is tripeptide; glycyl-L-histidyl-lysyl GHK-Cu (glycy1-histidy1-lysine), is a small copper-binding peptide naturally present in human plasma. It can be synthesized chemically or produced by enzymatic hydrolysis of proteins. This small molecule protein has excellent safety. A large number of studies have shown that blue copper peptide has excellent effects on improving skin aging conditions, which makes blue copper peptide indispensable in skin care products for anti-aging and skin protection. In addition, it has also been proven to greatly improve various adverse ski...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/41A61K8/365A61Q19/00A61Q19/08
CPCA61K8/64A61K8/416A61K8/365A61Q19/00A61Q19/08A61K2800/592
Inventor 胡露张嘉恒孙云起郭朝万刘天齐
Owner GUANGDONG MARUBI BIOLOGICAL TECH CO LTD
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