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Long-acting flunixin meglumine injection and preparation method thereof

The technology of flunixin meglumine and injection is applied in the field of long-acting flunixin meglumine injection and preparation thereof, and can solve the problems of poor stability, poor raw material ratio effect, low drug efficacy and the like, To achieve the effect of strong compatibility, improved dissolution effect, and improved drug efficiency

Pending Publication Date: 2022-02-15
江西利德菲生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing flunixin meglumine injection uses flunixin meglumine as the main agent, and the raw material proportioning effect is not good, resulting in poor stability and low efficacy and efficiency. Improved treatment of methylamine injection

Method used

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  • Long-acting flunixin meglumine injection and preparation method thereof
  • Long-acting flunixin meglumine injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] The preparation method of the carrier modifier of the present embodiment is:

[0031] S1: The modification method of modified starch is: put the starch into deionized water for gelatinization, the gelatinization time is 1-5min, and the gelatinization is completed;

[0032] S2: Then add heat-treated castor oil, continue stirring at a speed of 100-300r / min for 15-25min, and the stirring is completed to obtain modified starch;

[0033] S3: Mix the modified starch and chitosan solution according to the weight ratio of 1:3, then add nano-calcium carbonate with 1-5% of the total amount of modified starch, stir at a speed of 100-600r / min for 25-35min, and stir At the end, the carrier modifier is obtained.

[0034] The gelatinization temperature in the modification of the modified starch in this embodiment is 55-65°C.

[0035] The gelatinization temperature in the modification of the modified starch in this embodiment is 60°C.

[0036] The heat-treated castor oil of the pres...

Embodiment 1

[0044] A kind of long-acting flunixin meglumine injection of the present embodiment comprises the following raw materials in parts by weight:

[0045] Flunixin meglumine 1 part, carrier modifier 1 part, co-solvent 0.2 part, Tween 0.1 part, PVP 0.1 part.

[0046] The preparation method of the carrier modifier of the present embodiment is:

[0047] S1: The modification method of modified starch is: put the starch into deionized water for gelatinization, the gelatinization time is 1min, and the gelatinization is completed;

[0048] S2: Then add heat-treated castor oil, continue stirring at a speed of 100r / min for 15min, and finish stirring to obtain modified starch;

[0049] S3: Mix the modified starch and chitosan solution according to the weight ratio of 1:3, then add 1% of the total amount of modified starch nano-calcium carbonate, stir at a speed of 100r / min for 25min, and after the stirring is completed, the modified carrier is obtained. agent.

[0050] The gelatinization...

Embodiment 2

[0059] A kind of long-acting flunixin meglumine injection of the present embodiment comprises the following raw materials in parts by weight:

[0060] Flunixin meglumine 7 parts, carrier modifier 2 parts, co-solvent 0.6 part, Tween 0.5 part, PVP 0.4 part.

[0061] The preparation method of the carrier modifier of the present embodiment is:

[0062] S1: The modification method of modified starch is: put the starch into deionized water for gelatinization, the gelatinization time is 5min, and the gelatinization is completed;

[0063] S2: Then add heat-treated castor oil, continue stirring at a speed of 300r / min for 25min, and finish stirring to obtain modified starch;

[0064] S3: Mix the modified starch and chitosan solution according to the weight ratio of 1:3, then add 5% of the total amount of modified starch nano-calcium carbonate, stir at a speed of 600r / min for 35min, after the stirring is completed, the modified carrier is obtained. agent.

[0065] The gelatinization t...

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Abstract

The invention relates to a long-acting flunixin meglumine injection. The long-acting flunixin meglumine injection is prepared from the following raw materials in parts by weight: 1 to 7 parts of flunixin meglumine, 1 to 2 parts of a carrier modifier, 0.2 to 0.6 part of a cosolvent, 0.1 to 0.5 part of Tween and 0.1 to 0.4 part of PVP. According to the long-acting flunixin meglumine injection, flunixin meglumine and the carrier modifier are matched, the added cosolvent, Tween and other raw materials can improve the drug effect of an injection product; during addition of the carrier modifier, through modification matching of the modified starch and addition of castor oil, the adhesion and dissolution rate of the starch are improved; and meanwhile, the added chitosan solution is high in compatibility, and through cooperation of the chitosan solution, the dissolution efficiency of the product is further improved, the dissolution effect of the product is improved, the stability and the drug efficiency of the product are enhanced, and the drug efficiency of the product is further improved.

Description

technical field [0001] The invention relates to the technical field of flunixin meglumine, in particular to a long-acting flunixin meglumine injection and a preparation method thereof. Background technique [0002] Amoflunixin meglumine is an organic compound with a molecular weight of 491.4581, white powder. Veterinary medicine can relieve inflammation and pain caused by muscle abnormalities, relieve horses' visceral colic, and treat foals' diarrhea, tremors, colitis, respiratory and other system diseases. Flunixin meglumine is an inhibitor of cyclooxygenase. By inhibiting the cyclooxygenase in the arachidonic acid reaction chain, it can reduce the production of prostaglandins and thromboxane and other inflammatory mediators, maintain normal blood pressure, relieve vascular Endothelial cell damage, maintenance of normal blood volume, etc., prevent E. coli endotoxin from increasing bronchial exudate in respiratory diseases, neutrophils, albumin aggregation in exudate, etc.,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/44A61K47/36A61K47/02A61K47/04A61K47/26A61K47/44A61P1/06A61P29/00A61P15/14A61P15/00
CPCA61K9/08A61K9/0019A61K31/44A61K47/36A61K47/02A61K47/26A61K47/44A61P1/06A61P29/00A61P15/14A61P15/00
Inventor 石松明朱纯朴何友
Owner 江西利德菲生物药业有限公司