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Application of broussonetia papyrifera flowers in preparation of drugs or sunscreen cosmetics for preventing and treating ultraviolet damage

A technology for cosmetics and paper mulberry, applied in the field of natural medicinal chemistry, to achieve the effect of reducing wrinkles and damage, reducing content, and promoting antioxidant function

Active Publication Date: 2022-02-18
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is no report on the effect of preventing skin ultraviolet damage on the application of mulberry in the existing patents

Method used

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  • Application of broussonetia papyrifera flowers in preparation of drugs or sunscreen cosmetics for preventing and treating ultraviolet damage
  • Application of broussonetia papyrifera flowers in preparation of drugs or sunscreen cosmetics for preventing and treating ultraviolet damage
  • Application of broussonetia papyrifera flowers in preparation of drugs or sunscreen cosmetics for preventing and treating ultraviolet damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of Tree Flowers

[0017] Take the trendy flower, dry, pulverized sieve, to the tree powder; from the petroleum ether (30 ~ 60 ° C boiling range) reflow degreasing, the solvent is swolled in the vent, drying in an oven at 50 ° C; The tree flowers and deionized water are mixed with 1:30 (w / v), and heat at 60 ° C for 2 h, extract 3 times, combined extract, and extract the above extract, take the supernatant to steam to the original volume 1 / 5, concentrate; 3x volume of absolute ethanol is added to the concentrate, and the refrigerator is placed at 4 ° C for 24 h, centrifuged, and the precipitate separately with anhydrous ethanol, acetone, diethyl ether, dissolved in 30 ml deionized water, plus Deion water 1 / 3 volume of chloroform-n-butanol (V 氯仿 : V 正丁醇 = 4: 1), mixed with stirring for 1 h, 8000 r / min centrifuge for 20 min, resulting in supernatant, repeated operation to the solution no longer contains precipitation; placing the supernatant into the...

Embodiment 2

[0020] Example 2 Tree flower polysaccharide oxidation activity determination

[0021] 1. Determination of DPPH Free-based Clear Capacity

[0022] Measurement method: formulated 0.1 mg / ml DPPH stock solution, formulated concentration of 1, 2, 3, 4, 5 mg / ml of tree flows polysaccharide sample solution and ascorbic acid solution, 2 ml of each of them, add 2 ml of 0.1 mg / ml DPPH solution , Shake well, place it in dark 30 min, and test the absorbance A at wavelength 517 nm 样品 ; Replace DPPH solution in anhydrous ethanol, measure absorbance a 对照 Use anhydrous ethanol instead of tree flower polysaccharide sample solution is a 空白 . Calculate the average of three sets of parallel experiments.

[0023] DPPH free radical clearance = [1- (a 样品 -A 对照 ) / A 空白 ] × 100%.

[0024] 2. Determination of hydroxyl free radical clearance

[0025] Measurement method: The formulation concentration is 0.5, 1, 1.5, 2, 2.5 mg / ml of the tree, atrochemical sample solution and ascorbic acid solution, 2...

Embodiment 3

[0031] Preparation Example 3 mulberry flowers embodiment polysaccharide hydrogels

[0032] Hydrogel matrix: Weigh 1g Carbopol 940 100mL water overnight to swell, gel pH adjusted with triethanolamine to 6.5.

[0033] Mulberry flowers low dose polysaccharide hydrogel: mulberry flowers accurately weighed polysaccharide (preparation described in Example 1) 600mg, fully dissolved with a small amount of deionized water was added to the formulation good hydrogel matrix, stir, washed with water gel made up to 10g, mixed uniformly to obtain the desired concentration of 60mg / ml hydrogel formulation.

[0034] Mulberry flowers high dose of polysaccharide hydrogel: mulberry flowers accurately weighed polysaccharide (preparation described in Example 1) 800mg, fully dissolved with a small amount of deionized water was added to the deployment of a good gel matrix, stir, made up with water gel to 10g, mixed uniformly to obtain the desired concentration of 80mg / ml hydrogel formulation.

[0035]...

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Abstract

The invention provides application of broussonetia papyrifera flowers in preparation of drugs or sunscreen cosmetics for preventing and treating ultraviolet damage. Specifically, the antioxidant activity of broussonetia papyrifera polysaccharide is investigated by adopting an in-vitro antioxidant activity experiment, and the protective effect of the broussonetia papyrifera polysaccharide on the skin of an ultraviolet injury model mouse is investigated. Research results show that the broussonetia papyrifera polysaccharide has good effects of removing DPPH free radicals, hydroxyl free radicals and superoxide anion free radicals, and has good protection and repair effects on UVA-induced ultraviolet injury model mouse skin. The broussonetia papyrifera is a natural foodstuff which is popular in the folk and high in external use safety, is expected to become an effective active component for resisting ultraviolet damage, and has a wide development prospect in preparation of external medicines for preventing and treating ultraviolet damage or sunscreen cosmetics.

Description

Technical field [0001] The present invention belongs to the field of natural drug chemistry, and in particular, the apparatus for preparation of drugs or sunscreen cosmetics for preventing ultraviolet injury. Background technique [0002] As the human socioeconomic level continues to improve, the living environment is deteriorated, such as ozone cavity makes high frequency ultraviolet rays more incident in the earth, and the short-term injury is increasingly common. According to the wavelength and biological effect, ultraviolet rays can be divided into 3 bands: long wave UV (UVA), medium wave UV (UVB), short-wave UV (UVC), where UVA has strong penetration, can reach the skin of the skin It will quickly cause the skin's pigmentation, and UVA is not affected by altitude and atmosphere, and the penetration capacity is extremely strong. [0003] Skin continues to expose to ultraviolet irradiation to cause ultraviolet injury, which is characterized by the structure and function of ski...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K31/715A61K8/73A61K8/9789A61P17/16A61Q17/04C08B37/00
CPCA61K36/60A61K31/715A61K8/9789A61K8/73A61P17/16A61Q17/04C08B37/0003
Inventor 由天辉段雪伟杨慧文刘冰曾诚
Owner GUANGDONG PHARMA UNIV
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