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Magnetic induction medium heating slow release method for tumor treatment

A technology for tumor treatment and media heating, applied in the field of tumor treatment, can solve the problems of poor biocompatibility, affect the treatment effect, limit the efficiency of drug delivery in tumor tissue, etc., achieve controlled release speed, good magnetic compliance, and improve drug invisibility sexual effect

Pending Publication Date: 2022-03-01
JINAN YOUKE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main means and methods of treating cancer include surgery, radiotherapy and chemotherapy, but these methods are very risky, and are likely to cause major trauma and complications to patients. greater damage
[0004] With the research and development of tumor treatment technology, there has been a treatment plan using drug carriers to deliver drugs, but in actual use, there are problems of poor biocompatibility and inaccurate administration positions, which limit the The drug delivery efficiency to tumor tissue affects the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for sustained release of heat from a magnetic induction medium for tumor treatment, comprising:

[0029] S1. Prepare composite magnetic nanoparticles loaded with tumor therapeutic drugs, and sequentially coat the surface of the particles with a slow-release layer and a cell membrane layer to obtain product A;

[0030] Specifically, in this step

[0031] Preparation of composite magnetic nanoparticles:

[0032] By electrostatic interaction, in Fe 3 o 4 The surface of the core layer is coated with a layer of graphene wall layer to form Fe 3 o 4 nanospheres. in Fe 3 o 4 In nanospheres, Fe 3 o 4 The core layer has good magnetic parasitic and magnetocaloric properties, and graphene has good photothermal properties, thus making Fe 3 o 4 Nano-microspheres can achieve the synergistic control effect of magneto-thermal and photothermal.

[0033] Through electrostatic interaction, at least one chitosan wall layer and at least one sodium alginate wall layer are...

Embodiment 2

[0041] A method for sustained release of heat from a magnetic induction medium for tumor treatment, comprising:

[0042] S1. Prepare composite magnetic nanoparticles loaded with tumor therapeutic drugs, and sequentially coat the surface of the particles with a slow-release layer and a cell membrane layer to obtain product A;

[0043] Specifically, in this step

[0044] Preparation of composite magnetic nanoparticles:

[0045] By electrostatic interaction, in Fe 3 o 4 The surface of the core layer is coated with a layer of graphene wall layer to form Fe 3 o 4 nanospheres. in Fe 3 o 4 In nanospheres, Fe 3 o 4 The core layer has good magnetic parasitic and magnetocaloric properties, and graphene has good photothermal properties, thus making Fe 3 o 4 Nano-microspheres can achieve the synergistic control effect of magneto-thermal and photothermal.

[0046] Through electrostatic interaction, at least one chitosan wall layer and at least one sodium alginate wall layer are...

Embodiment 3

[0054] A method for sustained release of heat from a magnetic induction medium for tumor treatment, comprising:

[0055] S1. Prepare composite magnetic nanoparticles loaded with tumor therapeutic drugs, and sequentially coat the surface of the particles with a slow-release layer and a cell membrane layer to obtain product A;

[0056] Specifically, in this step

[0057] Preparation of composite magnetic nanoparticles:

[0058] By electrostatic interaction, in Fe 3 o 4 The surface of the core layer is coated with a layer of graphene wall layer to form Fe 3 o 4 nanospheres. in Fe 3 o 4 In nanospheres, Fe 3 o 4 The core layer has good magnetic parasitic and magnetocaloric properties, and graphene has good photothermal properties, thus making Fe 3 o 4 Nano-microspheres can achieve the synergistic control effect of magneto-thermal and photothermal.

[0059] Through electrostatic interaction, at least one chitosan wall layer and at least one sodium alginate wall layer are...

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PUM

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Abstract

The invention belongs to the technical field of tumor treatment, and discloses a magnetic induction medium heating slow release method for tumor treatment, which comprises the following steps: S1, preparing a composite magnetic nanoparticle loaded with a tumor treatment drug, and sequentially coating the surface of the particle with a slow release layer and a cell membrane layer to obtain a product A; s2, dissolving the product A in a target cell culture solution, and ultrasonically dispersing the culture solution uniformly to obtain a product B; s3, injecting the product B into a tumor blood supply vessel by using an intervention technology, providing an orthogonal magnetic field and near-infrared illumination in vitro, and enabling the tumor to be located in an area of the orthogonal magnetic field and the near-infrared illumination; wherein the composite magnetic nano particles comprise Fe3O4 nano microspheres and porous nano carbon fibers, and the tumor treatment medicine is one or more of adriamycin, paclitaxel and cis-platinum; in conclusion, the magnetic induction medium can reach a diseased part in a targeted mode under the action of a magnetic field, and then effective slow release of the tumor treatment medicine is achieved through magnetic heat and photo-thermal under irradiation of an orthogonal magnetic field and near-infrared light.

Description

technical field [0001] The invention belongs to the technical field of tumor treatment, and in particular relates to a method for slow-release heating of a magnetic induction medium for tumor treatment. Background technique [0002] As a major disease that threatens human life and health, cancer has long been characterized by low cure rate, recurrence and high mortality. [0003] At present, the main means and methods of cancer treatment include surgery, radiotherapy and chemotherapy, but these methods are very risky, and are likely to bring major trauma and complications to patients. greater damage. [0004] With the research and development of tumor treatment technology, there has been a treatment plan using drug carriers to deliver drugs, but in actual use, there are problems of poor biocompatibility and inaccurate administration positions, which limit the The efficiency of drug delivery to tumor tissue affects the therapeutic effect. Contents of the invention [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/46A61K47/04A61K41/00A61K45/00A61P35/00B82Y5/00B82Y30/00B82Y40/00A61K47/52
CPCA61K9/5073A61K41/00A61K9/5068A61K9/501A61K9/0009A61K45/00A61K9/0019A61K41/0052A61K41/0038B82Y5/00B82Y30/00B82Y40/00A61P35/00A61K47/52
Inventor 于保法
Owner JINAN YOUKE MEDICAL TECH CO LTD