Unlock instant, AI-driven research and patent intelligence for your innovation.

High-speed preparation method of vascular covered stent for emergency treatment of sudden coronary perforation during operation

A stent-graft and blood vessel technology, which is applied in the field of preparation of vascular stent-grafts, can solve the problems of fragility, poor stability, and easy unloading of the stent-graft, and achieves the effects of low cost and fast film formation.

Active Publication Date: 2022-03-11
HARBIN INST OF TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention is to solve the technical problems that the existing self-made stent grafts are easy to unload, fragile, poor in stability and large in outer diameter, and provide a High-speed preparation method of vascular covered stent for emergency coronary perforation during operation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • High-speed preparation method of vascular covered stent for emergency treatment of sudden coronary perforation during operation
  • High-speed preparation method of vascular covered stent for emergency treatment of sudden coronary perforation during operation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: The high-speed preparation method of the vascular stent-graft for emergency treatment of sudden coronary perforation in this embodiment is carried out according to the following steps:

[0033] 1. Weigh 3g cellulose acetate, 8g isoprene, 20g crotonic acid, 1g CuI and 1.5g bipyridine;

[0034] 2. Dissolve the cellulose acetate weighed in step 1 in 20mL of N,N-dimethylformamide, heat and stir at 70°C until completely dissolved, and cool to room temperature to obtain a cellulose acetate solution;

[0035] 3. Add the isoprene weighed in step 1 to the cellulose acetate solution, and stir at room temperature for 20 hours under nitrogen protection; then fully mix the CuI and bipyridyl weighed in step 1 and add it to the cellulose acetate solution , reacted in an oil bath at 100°C for 8 hours under the protection of nitrogen, and cooled to room temperature after the reaction was completed;

[0036] 4. Add the crotonic acid weighed in step 1 to the cellulose aceta...

Embodiment 2

[0047] Embodiment 2: The high-speed preparation method of the vascular stent-graft for emergency treatment of sudden coronary perforation in this embodiment is carried out according to the following steps:

[0048] 1. Weigh 5.0g polyvinylidene fluoride, 30g acrylic acid, 1.5g CuBr and 2.0g HMTETA;

[0049] 2. Dissolve the polyvinylidene fluoride weighed in step 1 in N-methylpyrrolidone, heat and stir at 80°C until completely dissolved, and cool to room temperature to obtain a polyvinylidene fluoride solution;

[0050] 3. Add butadiene into the polyvinylidene fluoride solution, and stir for 20 hours at room temperature under the protection of nitrogen. Then fully mix the CuBr and HMTETA weighed in step 1 and add them to the polyvinylidene fluoride solution, react in an oil bath at 50°C for 8 hours under the protection of nitrogen, and cool to room temperature after the reaction is completed;

[0051] 4. Add the acrylic acid weighed in step 1 to the polyvinylidene fluoride solu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
elongation at breakaaaaaaaaaa
Login to View More

Abstract

The invention discloses a high-speed preparation method of a blood vessel covered stent for emergency treatment of sudden coronary perforation in an operation, relates to the field of preparation of blood vessel covered stents, and aims to solve the technical problems that an existing covered stent is easy to deload, fragile, poor in stability and large in outer diameter. The method comprises the following steps: firstly, preparing a basement membrane material, then preparing a membrane casting solution, soaking a pipe network-shaped intravascular stent with a balloon in the membrane casting solution, taking out the pipe network-shaped intravascular stent, and putting the pipe network-shaped intravascular stent into a coagulating bath to obtain a layer of tightly-coated and completely-cured membrane on the surface of the stent, thereby completing the preparation of the covered vascular stent. The self-made blood vessel covered stent is high in preparation speed, can be prepared within 11-105 s, is good in tensile property and stability, small in membrane thickness, extremely small in influence on the outer diameter of the blood vessel stent, not prone to load shedding and capable of being used in the medical field.

Description

technical field [0001] The invention relates to a preparation method of a vascular covered stent. Background technique [0002] The incidence of various cardiovascular diseases is increasing year by year, and percutaneous coronary intervention (PCI) has become an important treatment for cardiovascular diseases. Percutaneous transluminal angioplasty is to use a puncture needle, a guide wire and a guide sheath to insert a balloon catheter covered with a tightened stent into a human blood vessel, and deliver it to the stenosis of the blood vessel. With the expansion of the balloon, the stent is also stretched After the balloon is retracted and retracted, the deformed metal stent remains in place to expand the blood vessel. [0003] Although percutaneous transluminal angioplasty is a relatively mature technology, it still cannot avoid the rupture of blood vessels due to operational errors and other reasons, especially the rupture of blood vessels caused by misoperation of punct...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/10A61L31/16A61F2/90
CPCA61L31/14A61L31/10A61L31/16A61F2/90A61L2300/404A61L2300/21A61L2300/606A61L2400/04C08L1/12C08L27/16
Inventor 姜再兴纪媛井晶张大伟董继东高国林李冰马丽娜黄玉东邵路
Owner HARBIN INST OF TECH