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Anti-adhesion membrane as well as preparation method and application thereof

An anti-adhesion film and nanofiber technology, applied in adhesive dressings, non-adhesive dressings, medical science, etc., can solve the problems of lack of anti-inflammatory and anti-fiber, limited application effect, etc., achieve strong mechanical properties, prevent adhesions, and good suturing performance Effect

Pending Publication Date: 2022-03-25
SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tissue barriers currently on the market, such as And other products, can only play the role of physical barrier, lack of anti-inflammatory and anti-fiber effect, therefore, the actual application effect is often limited

Method used

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  • Anti-adhesion membrane as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) The airgel material and the active ingredient are blended in water to form a mixed solution, and the container is not powered;

[0020] (2) Spin nanofiber materials into the mixed solution prepared in step (1) by electrospinning, during electrospinning, the spinneret head moves in one direction, and spins into nanofibers arranged in disorder;

[0021] (3) freeze-drying the mixed solution prepared in step (2) to obtain the anti-adhesion film.

[0022] The airgel material used in this example is polyvinyl alcohol, the active ingredient is melatonin, and the nanofiber material is PLCL.

Embodiment 2

[0024] (1) The airgel material and the active ingredient are mixed in water to form a mixed solution, and the left and right sides of the container are negatively charged;

[0025] (2) Spin positively charged nanofiber materials into the mixed solution prepared in step (1) by electrospinning. The fibers are finally arranged in one direction;

[0026] (3) freeze-drying the mixed solution prepared in step (2) to obtain the anti-adhesion film.

[0027] The airgel material used in this example is polyvinyl alcohol (PVA), the active ingredient is melatonin, and the nanofiber material is poly-L-lactide-co-caprolactone (PLCL).

Embodiment 3

[0029] (1) The airgel material and the active ingredient are blended in water to form a mixed solution;

[0030] (2) Spin nanofibrous materials into the mixed solution prepared in step (1) by electrospinning. During electrospinning, fix the spinning needle, and move or rotate the lower mixed solution device to make the mixed solution spun into a high disordered nanofibers;

[0031] (3) freeze-drying the mixed solution prepared in step (2) to obtain the anti-adhesion film.

[0032] The airgel material used in this example is polyvinyl alcohol (PVA), the active ingredient is melatonin, and the nanofiber material is poly-L-lactide-co-caprolactone (PLCL).

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PUM

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Abstract

The invention discloses an anti-adhesion membrane, the top surface of the anti-adhesion membrane is of a longitudinally and transversely arranged nanofiber structure, the bottom surface of the anti-adhesion membrane is of a smooth aerogel structure, the longitudinal surface of the anti-adhesion membrane is of a layered macroporous structure, and active ingredients are carried in the anti-adhesion membrane. The anti-adhesion membrane has the advantages that the top surface structure strengthens the stitchability of the anti-adhesion membrane, the bottom surface structure reduces the adhesion of cells, and the longitudinal surface structure ensures the carrying of active pharmaceutical ingredients; compared with a traditional anti-adhesion material, the anti-adhesion membrane has higher mechanical property, better sewing performance and higher anti-fiber and anti-inflammatory performance, and adhesion can be effectively prevented.

Description

technical field [0001] The present application relates to the technical field of polymer materials, in particular to an anti-adhesion film and its preparation method and application. Background technique [0002] Tissue adhesions are the most common postoperative complication of surgical procedures. The occurrence of tissue adhesion is related to the destruction of tissue barrier, the infiltration of inflammatory cells and the proliferation of fibroblasts. Therefore, postoperative reconstruction of a functional (anti-inflammatory and anti-fibrous) tissue barrier can effectively prevent the occurrence of postoperative adhesions. Tissue barriers currently on the market, such as And other products can only play the role of physical barriers, lack of anti-inflammatory and anti-fiber effects, therefore, the actual application effect is often limited. [0003] It should be noted that the data disclosed in the above background technology section are only used to enhance the und...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61F13/00
CPCA61F13/023A61F13/0233A61F13/0236A61F13/0266A61F13/0259A61F13/0276A61F13/0286A61F13/00063A61F2013/00217A61F13/01034A61F13/01008A61F13/01029Y02W90/10
Inventor 殷猛金大为匡海珠
Owner SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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