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Method for preparing human dura mater repair material with simulated ECM (Extracellular Matrix) component and structure through long fiber network skeleton preforming process

A repair material and long-fiber technology, applied in prosthesis, tissue regeneration, medical science, etc., can solve toxicity and other problems, achieve large tensile strain, ensure biocompatibility, improve toughness and sutureability

Active Publication Date: 2021-06-08
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But cross-linking agent glutaraldehyde needs to be used in the preparation of the porous layer of this dura mater patch, and glutaraldehyde has certain toxicity, if it is not cleaned, it will have a very adverse effect on the use in the human body; and the use of bacteria As a reinforcing material for chitosan-based meninges, cellulose has the disadvantage that there is no enzyme that can degrade bacterial cellulose in the human body, which is equivalent to requiring a second operation to remove foreign bodies

Method used

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  • Method for preparing human dura mater repair material with simulated ECM (Extracellular Matrix) component and structure through long fiber network skeleton preforming process
  • Method for preparing human dura mater repair material with simulated ECM (Extracellular Matrix) component and structure through long fiber network skeleton preforming process
  • Method for preparing human dura mater repair material with simulated ECM (Extracellular Matrix) component and structure through long fiber network skeleton preforming process

Examples

Experimental program
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Effect test

Embodiment 1

[0068] A preparation method of a human dura mater repair material imitating ECM composition and structure, comprising the steps of:

[0069] (1) Soak chitosan long fiber material (length is 2cm) and chitosan short fiber material (length is 3mm) respectively in the moistening liquid (0.5wt% sodium hydroxide solution), carry out pretreatment (water absorption Rinse up for 8 hours), rinse the slurry with deionized water until the pH value of the slurry lotion is neutral, obtain the pretreated chitosan long fiber material and the pretreated chitosan short fiber material; silk long Fiber (length 2cm) and silk short fiber (length 3mm) were soaked in Na 2 CO 3 Solution (mass percentage concentration is 1wt%, silk fiber and Na 2 CO 3 The solid-to-liquid ratio of the solution is 1:5g / mL), and the decollagenization treatment is carried out under stirring (in a water bath, the temperature is 100°C, and the time is 1h), and after the water bath, rinse the fiber with a large amount of d...

Embodiment 2

[0075] A preparation method of a human dura mater repair material imitating ECM composition and structure, comprising the steps of:

[0076] (1) Chitosan long fiber material (length is 3cm) and chitosan short fiber material (length is 4mm) are soaked respectively in moistening liquid (1wt% sodium hydroxide solution), carry out pretreatment (absorbing moisture up 8 hours), rinse the slurry with deionized water until the pH value of the slurry washing solution is neutral, obtain the pretreated chitosan long fiber material and the pretreated chitosan short fiber material; the silk long fiber (length 3cm) and short silk fibers (length 4mm) were soaked in Na 2 CO 3 Solution (mass percentage concentration is 1wt%, silk fiber and Na 2 CO 3The solid-to-liquid ratio of the solution is 1:5), and the decollagenization treatment is carried out in a stirring state (in a water bath state, the temperature is 100 ° C, and the time is 1 h). After the water bath, the fibers are washed with a...

Embodiment 3

[0082] A preparation method of a human dura mater repair material imitating ECM composition and structure, comprising the steps of:

[0083] (1) Soak chitosan long fiber material (length is 4cm) and chitosan short fiber material (length is 3mm) respectively in the moistening liquid (1.5wt% sodium hydroxide solution), carry out pretreatment (water absorption Rinse up for 8 hours), rinse the slurry with deionized water until the pH value of the slurry lotion is neutral, obtain the pretreated chitosan long fiber material and the pretreated chitosan short fiber material; silk long Fiber (length 4cm) and silk short fiber (length 3mm) were soaked in Na 2 CO 3 Solution (mass percentage concentration is 1wt%, silk fiber and Na 2 CO 3 The solid-to-liquid ratio of the solution is 1:5), and the decollagenization treatment is carried out in a stirring state (in a water bath state, the temperature is 100 ° C, and the time is 1 h). After the water bath, the fibers are washed with a large...

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Abstract

The invention discloses a method for preparing a human dura mater repair material with simulated ECM (Extracellular Matrix) component and structure through a long fiber network skeleton preforming process. The method for preparing the human dura mater repair material with the simulated ECM component and structure comprises the following steps: preconditioning chitosan fibers by using a moistening and swelling solution, and carrying out collagen removal treatment on silk fibers by using a Na2CO<3> solution; washing the chitosan fibers and the silk fibers, and carrying out beating (grinding) treatment; diluting the beaten (ground) fiber pulp into a fiber suspension, and separately preparing fiber pulp with different lengths into thin layers of a long fiber interwoven framework material and a short fiber interwoven base material; compounding the thin layers of the long fiber interwoven framework material and the short fiber interwoven base material into a chitosan-silk paper-based material; and then, carrying out non-chemical crosslinking physical dip coating treatment to obtain the human dura mater repair material. The material prepared by the method has good toughness and stitchability, is easy to industrialize, and has a good application prospect.

Description

technical field [0001] The invention relates to the field of human tissue engineering repair materials, in particular to a method for preparing a human dura mater repair material imitating ECM components and structure by a long fiber network skeleton preforming method. Background technique [0002] The human dura mater is a thick and tough double-layer membrane. Its outer layer is loosely attached to the skull cap, and its inner layer is thick and tough. It is connected with the dura mater at the foramen magnum. It is an important barrier to protect brain tissue. The structure and function of the brain nervous system are of great significance. Traumatic brain injury and surgery can cause dural defects. Reconstruction of the dura mater has reached a consensus in the field of neurosurgery and has become an important and basic operation step in brain surgery. The defective dura mater is reconstructed through neurosurgery to seal the subdural space. The integrity and compatibil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/36A61L27/50A61L27/56A61L27/58
CPCA61L27/20A61L27/3604A61L27/3675A61L27/3691A61L27/3687A61L27/50A61L27/56A61L27/58A61L2430/32C08L5/08
Inventor 牟永告赵光磊
Owner SOUTH CHINA UNIV OF TECH
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